申请人：Hubschwerlen Christian
公开号：US20140171425A1
公开（公告）日：2014-06-19
The invention relates to antibacterial compounds of formula (I), wherein R
1
is H, halogen, (C
1
-C
3
)alkyl or (C
1
-C
3
)alkoxy; R
2
is H, halogen, (C
1
-C
3
)alkyl, (C
1
-C
3
)alkoxy or pyrrolidin-1-yl; R
3
is H, halogen, (C
1
-C
3
)alkyl, (C
1
-C
3
)alkoxy, vinyl or 2-methoxycarbonyvinyl or R
2
and R
3
together with the two carbon atoms which bear them form a phenyl ring; R
4
is H, halogen, (C
1
-C
3
)alkyl or (C
1
-C
3
)alkoxy; and R
5
is H, (C
1
-C
3
)alkyl or cyclopropyl, or R
4
and R
5
form together a —CH
2
CH
2
CH
2
— group; A is the divalent group —CH
2
—, —CH
2
CH
2
—, #—CH(OH)CH
2
—*, #—CH
2
N(R
6
)—* and —CH
2
NHCH
2
—, wherein # indicates the point of attachment to the optionally substituted (quinazoline-2,4-dione-3-yl)methyl residue and * represents the point of attachment to the substituted (oxazolidinon-4-yl)methyl residue; R
6
is H or acetyl; Y is CH or N; and Q is O or S; and salts of such compounds.
该发明涉及式(I)的抗菌化合物，其中R1为H、卤素、(C1-C3)烷基或(C1-C3)氧烷；R2为H、卤素、(C1-C3)烷基、(C1-C3)氧烷或吡咯烷-1-基；R3为H、卤素、(C1-C3)烷基、(C1-C3)氧烷、乙烯基或2-甲氧羰基乙烯基，或R2和R3与携带它们的两个碳原子一起形成苯环；R4为H、卤素、(C1-C3)烷基或(C1-C3)氧烷；R5为H、(C1-C3)烷基或环丙基，或R4和R5一起形成一个—CH2CH2CH2—基团；A为二价基团—CH2—、—CH2CH2—、#—CH(OH)CH2—*、#—CH2N(R6)—*和—CH2NHCH2—，其中#表示可选择取代的(喹唑啉-2,4-二酮-3-基)甲基残基的连接点，*表示取代的(噁唑烷酮-4-基)甲基残基的连接点；R6为H或乙酰基；Y为CH或N；Q为O或S；以及这类化合物的盐。
