(1S)-(-)-10-巯基异冰片 | 71242-58-5

• 物质功能分类: 生物化工 - 中草药成分
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: (1S)-(-)-10-巯基异冰片
• 中文别名: (1S)-(-)-1-巯基异冰片
• 英文名称: (10)-Mercaptoisoborneol
• 英文别名: (+)-(10)-mercaptoborneol；(1S)-(-)-10-Mercaptoborneol；7,7-dimethyl-1-(sulfanylmethyl)bicyclo[2.2.1]heptan-2-ol
• CAS: 71242-58-5
• 化学式: C₁₀H₁₈OS
• mdl: MFCD02093580
• 分子量: 186.318
• InChiKey: PYQMNINTTPIRIT-UHFFFAOYSA-N

物化性质

• 熔点：
  72 °C
• 溶解度：
  在氯仿中几乎透明
• 稳定性/保质期：
  正常条件下稳定，远离氧化物。

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 储存条件：
  存放在密封容器内，并置于阴凉、干燥处。请将储存地点远离氧化剂，避免靠近热源和火源，并确保避光保存。

SDS

(1S)-(-)-10-Mercaptoisoborneol Revision number: 5
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: (1S)-(-)-10-Mercaptoisoborneol

Revision number: 5

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
Not classified
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols None
No signal word
Signal word
Hazard statements None
None
Precautionary statements:

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: (1S)-(-)-10-Mercaptoisoborneol
Percent: >98.0%(GC)
CAS Number: 71242-58-5
Chemical Formula: C10H18OS

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
(1S)-(-)-10-Mercaptoisoborneol

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Section 5. FIRE-FIGHTING MEASURES
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Form: Crystal- Powder
Colour: White - Almost white
Odour: No data available
pH: No data available
Melting point/freezing point:72°C
No data available
Boiling point/range:
Flash point: No data available
Flammability or explosive
limits:
No data available
Lower:
Upper: No data available
No data available
Relative density:
Solubility(ies):
No data available
[Water]
[Other solvents] No data available
(1S)-(-)-10-Mercaptoisoborneol

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Sulfur oxides
products:

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Section 11. TOXICOLOGICAL INFORMATION
No data available
Acute Toxicity:
Skin corrosion/irritation: No data available
No data available
Serious eye
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
No data available
Reproductive toxicity:

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
No data available
Soil adsorption (Koc):
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
Not listed
UN-No:

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
(1S)-(-)-10-Mercaptoisoborneol

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

(1S)-(-)-10-巯基异冰片是一种樟脑衍生物。可由（+）-10-樟脑磺酰氯为原料，先制备（1S）-10-巯基樟脑，然后还原羰基得到(1S)-(-)-10-巯基异冰片。

简介

(1S)-(-)-10-巯基异冰片也是一种樟脑衍生物。文献报道显示，该化合物可由可商购的（+）-10-樟脑磺酰氯为原料，先制备（1S）-10-巯基樟脑，然后还原羰基得到(1S)-(-)-10-巯基异冰片。

反应信息

• 作为反应物：
  描述：

  (1S)-(-)-10-巯基异冰片 、 苯膦酰二氯 、 三乙胺 生成 (1S,4S,6R,8R)-11,11-dimethyl-4-phenyl-5-oxa-3-thia-4λ5-phosphatricyclo[6.2.1.01,6]undecane 4-oxide
  参考文献：
  名称：

  TAKAHASHI, TAMIKO;MATSUI, NAKOTO;MAENO, NAOKO;KOIZUMI, TORU;SHIRO, MOTOO, HETEROCYCLES, 30,(1990) N, C. 353-357

  摘要：

  DOI：

文献信息

• [EN] NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS<br/>[FR] NOUVEAUX RÉACTIFS À BASE DE PHOSPHORE (V), LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION DANS LA FABRICATION DE COMPOSÉS ORGANOPHOSHOREUX (V) STÉRÉODÉFINIS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2019200273A1

  公开（公告）日：2019-10-17

  The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

  本发明涉及新型磷（V）（P(V)）试剂，其制备方法以及利用这种新型试剂制备有机磷（V）化合物的方法。
• ENANTIOMER ANALYSIS METHOD
  申请人：Ajinomoto Co., Inc.

  公开号：EP3358346A1

  公开（公告）日：2018-08-08

  An object is to develop a novel methodology which is excellent for the analysis of enantiomers. The object can be achieved by a method for analyzing an enantiomer including (1) to (3) below: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.

  目的是开发一种新型方法，该方法非常适合分析对映体。该目标可通过包括以下（1）至（3）的对映体分析方法来实现： (1) 将作为一对对映体的第一化合物和第二化合物的混合物与作为一对轴向手性异构体之一的轴向手性化合物反应，生成衍生物混合物，其中包含第一化合物与轴向手性化合物反应得到的第一衍生物和第二化合物与轴向手性化合物反应得到的第二衍生物； (2) 分离衍生物混合物中的第一衍生物和第二衍生物；以及 (3) 通过质谱法检测分离出的第一衍生物和第二衍生物。
• Transparent electrode and organic electronic device including the same
  申请人：Konica Minolta, Inc.

  公开号：US10675842B2

  公开（公告）日：2020-06-09

  A transparent electrode has excellent adhesion between a substrate and a conductive layer. A transparent electrode includes a substrate, an underlying layer, and a conductive layer sequentially stacked. The underlying layer contains at least one selected from a compound having a thiol group and a poly(meth)acrylate and a poly(meth)acrylamide each having an aminoethyl group.

  一种透明电极在基底和导电层之间具有极佳的附着力。透明电极包括依次堆叠的基底、底层和导电层。底层包含至少一种选自具有硫醇基团的化合物和具有氨基乙基的聚甲基丙烯酸酯和聚甲基丙烯酰胺。
• Method for analyzing enantiomer
  申请人：Ajinomoto Co., Inc.

  公开号：US11327060B2

  公开（公告）日：2022-05-10

  Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.

  可通过以下方法分析对映体： (1) 将作为一对对映体的第一种化合物和第二种化合物的混合物与作为一对轴向手性异构体之一的轴向手性化合物反应，生成衍生物混合物，其中包含第一种化合物与轴向手性化合物反应得到的第一衍生物，以及第二种化合物与轴向手性化合物反应得到的第二衍生物； (2) 分离衍生物混合物中的第一衍生物和第二衍生物；以及 (3) 通过质谱法检测分离出的第一衍生物和第二衍生物。
• PROCESS FOR THE PREPARATION OF AN OXIRANE, AZIRIDINE OR CYCLOPROPANE
  申请人：ZENECA LIMITED

  公开号：EP0724569A1

  公开（公告）日：1996-08-07