毛喉素 | 66428-89-5

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 毛喉素
• 中文别名: 佛司可林
• 英文名称: forskolin
• 英文别名: FSK；Forskolin Racemate；(3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl) acetate
• CAS: 66428-89-5
• 化学式: C₂₂H₃₄O₇
• 分子量: 410.508
• InChiKey: OHCQJHSOBUTRHG-UHFFFAOYSA-N

物化性质

• 沸点：
  519.9±50.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  7-Desacetylforskolin 、 乙酸酐 、 吡啶 以90%的产率得到
  参考文献：
  名称：

  COREY, E. J.;JARDINE, PAUL DA SILVA;ROHLOFF, JOHN C., J. AMER. CHEM. SOC., 110,(1988) N 11, 3672-3673

  摘要：

  DOI：

文献信息

• Methods for production of functional beta cells
  申请人：Janssen Biotech, Inc.

  公开号：US10633635B2

  公开（公告）日：2020-04-28

  The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.

  本发明提供了将胰腺内分泌细胞分化成表达PDX1、NKX6.1、MAFA、UCN3和SLC2A的胰腺β细胞的方法。这些胰腺β细胞可通过多能干细胞的逐步分化获得。胰岛β细胞表现出与胰岛细胞相似的葡萄糖依赖性线粒体呼吸和葡萄糖刺激的胰岛素分泌。
• CELL REPROGRAMMING METHODS FOR PRODUCING CHONDROCYTES
  申请人：Mogrify Limited

  公开号：EP3642329A1

  公开（公告）日：2020-04-29
• Agents for treating neurodegenerative diseases
  申请人：Stockwell R. Brent

  公开号：US20070027164A1

  公开（公告）日：2007-02-01

  The present invention relates to compounds effective in preventing neuronal cell death, which may be used in the treatment of neurodegenerative diseases. It is based, at least in part, on the discovery that particular compounds were effective in preventing neuronal death in model systems of Huntington's Disease.
• GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE
  申请人：Janssen Biotech, Inc.

  公开号：US20170362572A1

  公开（公告）日：2017-12-21

  The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.
• [EN] CELL REPROGRAMMING METHODS FOR PRODUCING CHONDROCYTES<br/>[FR] MÉTHODES DE REPROGRAMMATION CELLULAIRE POUR PRODUIRE DES CHONDROCYTES
  申请人：CELL MOGRIFY LTD

  公开号：WO2018232459A1

  公开（公告）日：2018-12-27

  The present invention relates to methods and compositions for reprogramming a source cell to produce a chondrocyte, the method comprising activating or increasing the protein expression of one or more transcription factors, or variants thereof, in the source cell.