N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for acute oral toxicity in male and female Sprague-Dawley albino rats. The test substance was fed by oral gavage at dose levels of 251, 316, 398, and 501 mg/kg. The mortality ratios were 0/2 M, 0/3 F; 1/3 M, 1/2 F; 1/2 M, 2/3 F; and 3/3 M, 2/2 F, respectively. Toxic signs included reduced appetite and activity, rapidly increasing weakness, collapse, and death. Autopsy findings included hemorrhagic lungs and liver and acute gastrointestinal inflammation. The LD50 was determined to be 360 mg/kg.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
TSCA 测试提交
N-丁基氯乙酸酯（CAS# 590-02-3）在新西兰白兔雄性和雌性中以100、200、316、501和1000 mg/kg的剂量水平进行了急性皮肤毒性评估。死亡率分别为0/1 F; 1/1 M, 1/1 F; 1/1 M, 1/1 F; 1/1 M; 和 1/1 F。毒性症状包括食欲和活动减少、迅速加重的虚弱、眼部分泌物、倒下和死亡。尸检发现包括肺和肝脏充血。LD50被确定为大于200 mg/kg且小于316 mg/kg。
N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for acute dermal toxicity in New Zealand white male and female rabbits at dose levels of 100, 200, 316, 501, and 1000 mg/kg. The mortality ratios were 0/1 F; 1/1 M, 1/1 F; 1/1 M, 1/1 F; 1/1 M; and 1/1 F, respectively. Toxic signs included reduced appetite and activity, rapidly increasing weakness, ocular discharge, collapse, and death. Autopsy findings included lung and liver hyperemia. The LD50 was determined to be greater than 200 mg/kg and less than 316 mg/kg.
N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for dermal irritation in three New Zealand white male and female rabbits at a dose level of 0.5 m/L applied undiluted to the intact skin. The test substance was a severe irritant with an average maximum score of 6.0 out of 8 in 24-hours. Observations following application included slight erythema and severe edema (24-hours) and no erythema or edema at 168-hours.
N-Butyl chloroacetatetyl ester (CAS# 590-02-3) was evaluated for eye irritation in three New Zealand white male and female rabbits at a dose level of 0.1 m/L. The test substance was classified as a mild eye irritation with an average maximum score of 16.6 out of 110 in 24-hours. Observations following application included moderate to severe erythema, including a diffuse, deep-crimson red appearance of the conjunctivae, with individual vessels not easily discernable; moderate edema; and moderate to copious discharge containing slight whitish exudate (24-hours). At 168-hours the eyes were normal with zero readings.
[EN] AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION<br/>[FR] DÉGRONIMÈRES DE C3-GLUTARIMIDE LIÉS À UNE AMINE POUR LA DÉGRADATION DE PROTÉINES CIBLES
申请人：C4 THERAPEUTICS INC
公开号：WO2017197051A1
公开（公告）日：2017-11-16
This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.
[EN] METHOD OF CONVERTING ALCOHOL TO HALIDE<br/>[FR] PROCÉDÉ DE CONVERSION D'UN ALCOOL EN HALOGÉNURE
申请人：UNIV SAARLAND
公开号：WO2016202894A1
公开（公告）日：2016-12-22
The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.
Synthesis of Ammonium 5-Arylcarbamoyl-4-heteryl-6-methyl-3-cyano-1,4-dihydropyridine-2-thiolates and 4-Heteryl-5-carbamoyl-6-methyl-3-cyano-1,4-dihydropyridine-2-selenolates
作者：V. D. Dyachenko
DOI：10.1007/s11176-005-0248-4
日期：2005.3
The condensation of enamines derived from acetoacetanilides, heterocyclic aldehydes, and cyanothioacetamide yielded ammonium 5-arylcarbamoyl-5-heteryl-6-methyl-3-cyano-1,4-dihydropyridine-2-thiolates, which were subsequently used for the synthesis of substituted 2-alkylthio-1,4-dihydropyridines, 2-alkylthiopyridines, and thieno[2,3-b]pyridines. The reaction of acetoacetamide with heteroaromatic aldehydes and cyanoselenoacetamide in the presence of N-ethylmorpholine yielded N-ethylmorpholinium 4-heteryl-5-carbamoyl-6-methyl-3-cyano-1,4-dihydrolyridine-2-selenolates, from which substituted 2-alkylseleno-1,4-dihydropyridines were prepared.
[EN] MALONONITRILE COMPOUND AND USE THEREOF AS PESTICIDES<br/>[FR] COMPOSE DE MALONONITRILE ET SON UTILISATION COMME PESTICIDE
申请人：SUMITOMO CHEMICAL CO
公开号：WO2004020399A1
公开（公告）日：2004-03-11
The present invention relates to a novel malononitrile compound represented by the formula (A): wherein, R1 represents C1 to C6 alkyl that may be substituted with halogen, C2 to C6 alkenyl that may be substituted with halogen, etc; R2 represents hydrogen atom or C1 to C6 alkyl that may be substituted with halogen; R3 represents hydrogen atom or C1 to C6 alkyl; R4 represents hydrogen atom or C1 to C6 alkyl; R5 represents C1 to C6 alkyl that may be substituted with halogen, C3 to C6 alkenyl that may be substituted with halogen, etc , or R4 and R5 may be combined at their terminal and represent ethylene that may be substituted with C1 to C3 alkyl or trimethylene that may be substituted with C1 to C3 alkyl; and Z1 and Z2, which are the same or different, represent oxygen atom or sulfur atom. The malononitrile compound has an efficient pesticidal activity and can control effectively pests such as insect pests, acarine pests, nematode pests and the like.
