2-硝基-1,4-二(戊-3-基)苯 | 851385-08-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 2-硝基-1,4-二(戊-3-基)苯
• 英文名称: 1,4-di(1-ethylpropyl)-2-nitrobenzene
• 英文别名: 1-nitro-2,5-di(pentan-3-yl)benzene；Benzene, 1,4-bis(1-ethylpropyl)-2-nitro-；2-nitro-1,4-di(pentan-3-yl)benzene
• CAS: 851385-08-5
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.38
• InChiKey: GKRHODSSGQBTLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-硝基-1,4-二(戊-3-基)苯 在 Ni (Raney) 一水合肼 作用下， 以 甲醇 为溶剂， 反应 0.12h， 以93%的产率得到2,5-di(1-ethylpropyl)phenylamine
  参考文献：
  名称：

  High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics

  摘要：

  Sterically demanding nitroaromatic compounds have been prepared and reduced to their corresponding amines with high intensity ultrasound using hydrazine in the presence of a Raney nickel catalyst. These reactions were dependent on catalyst quality, solvent and ultrasonic amplitude and, in comparison to their silent reactions, proceeded much faster and afforded higher yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.02.038
• 作为产物：
  描述：

  1,4-二(戊-3-基)苯 在 硝酸 作用下， 以 乙酸酐 、 溶剂黄146 为溶剂， 以48%的产率得到2-硝基-1,4-二(戊-3-基)苯
  参考文献：
  名称：

  High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics

  摘要：

  Sterically demanding nitroaromatic compounds have been prepared and reduced to their corresponding amines with high intensity ultrasound using hydrazine in the presence of a Raney nickel catalyst. These reactions were dependent on catalyst quality, solvent and ultrasonic amplitude and, in comparison to their silent reactions, proceeded much faster and afforded higher yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.02.038

文献信息

• An Easy Access to Aromatic Azo Compounds under Ultrasound/Microwave Irradiation
  作者：Giancarlo Cravotto、Luisa Boffa、Marco Bia、Werner Bonrath、Massimo Curini、Georgios Heropoulos

  DOI：10.1055/s-2006-951481

  日期：2006.9

  Chemoselective reduction of nitroarenes to azo and azoxy compounds was easily achieved using zinc powder and ­ammonium chloride in DMF or DMF-water (95:5) under high intensity ultrasound (US) or microwave (MW) irradiation, separately or combined. When carried out under conventional heating the reaction required much higher temperatures and gave lower yields. The addition of a small amount of water caused a dramatic increase in the reactivity, permitting the reduction of hindered nitroarenes at the expense of selectivity. A novel reactor for combined US/MW ­irradiation was employed which demonstrated additional beneficial effects.

  利用锌粉和氯化铵在DMF或DMF-水（95:5）中，在高强度超声（US）或微波（MW）辐照下，分别或结合地很容易实现对硝基芳烃的化学选择性还原成偶氮和偶氮氧化物。当在常规加热下进行反应时，需要更高的温度且产率较低。添加少量水显著提高了反应性，使得在牺牲选择性的情况下可以还原受阻的硝基芳烃。采用了一种新型反应器用于联合US/MW辐照，显示出额外的有益效果。
• High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics
  作者：Georgios A. Heropoulos、Spyros Georgakopoulos、Barry R. Steele

  DOI：10.1016/j.tetlet.2005.02.038

  日期：2005.4

  Sterically demanding nitroaromatic compounds have been prepared and reduced to their corresponding amines with high intensity ultrasound using hydrazine in the presence of a Raney nickel catalyst. These reactions were dependent on catalyst quality, solvent and ultrasonic amplitude and, in comparison to their silent reactions, proceeded much faster and afforded higher yields. (c) 2005 Elsevier Ltd. All rights reserved.