3,3',4,4'-四氨基二苯基醚 | 2676-59-7

• 物质功能分类: 有机原料 - 醚类化合物及其衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,3',4,4'-四氨基二苯基醚
• 中文别名: 3,3,4,4-四氨基二苯醚
• 英文名称: bis(3,4-diaminophenyl)ether
• 英文别名: 3,3',4,4'-tetraaminodiphenyl ether；3,3',4,4'-tetraaminodiphenyl oxide；4-(3,4-diaminophenoxy)benzene-1,2-diamine
• CAS: 2676-59-7
• 化学式: C₁₂H₁₄N₄O
• 分子量: 230.269
• InChiKey: RQBIGPMJQUKYAH-UHFFFAOYSA-N

物化性质

• 熔点：
  147-150 °C
• 沸点：
  477.3±45.0 °C(Predicted)
• 密度：
  1.361±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,3',4,4'-四氨基二苯基醚 在 potassium hydroxide 、 sodium hydroxide 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 9.0h， 生成
  参考文献：
  名称：

  Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents

  摘要：

  A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.01.019
• 作为产物：
  描述：

  4,4-二硝基二苯醚 在 尿素 sodium hydroxide 、 硝酸 、 乙酸酐 、 三氯化铁 、 甲烷 、 溶剂黄146 、 肼 作用下， 以 1,4-二氧六环 、 氯苯 、 异丙醇 、 正丁醇 为溶剂， 反应 19.0h， 生成 3,3',4,4'-四氨基二苯基醚
  参考文献：
  名称：

  Synthesis and Structure of Di[methoxy(ethoxy)carbonylamino-1H-benzimidazol-5-yl] Ethers

  摘要：

  开发了一种制备di[methoxy(ethoxy)carbonylamino-1H-benzimidazol-5-yl]醚的方法，该方法通过甲基或乙基氯甲酸酯与氰胺钠反应，然后将所得的甲基或乙基氰基氨基甲酸酯与4-(3,4-二氨基苯氧基)-1,2-苯二胺在酸性溶液中反应。

  DOI：

  10.1007/s11176-005-0459-8

文献信息

• [EN] POLYMERS FOR USE IN ELECTRONIC DEVICES<br/>[FR] POLYMÈRES DESTINÉS À ÊTRE UTILISÉS DANS DES DISPOSITIFS ÉLECTRONIQUES
  申请人：DUPONT ELECTRONICS INC

  公开号：WO2020018617A1

  公开（公告）日：2020-01-23

  In Formula I: Qa is CRX, SiRx, GeRx, PRX, or N; Qb is CRy, SiRy, GeRy, PRy, or N; R1, R2, and R3 are the same or different at each occurrence and are F, CN, alkyl, fluoroalkyl, unsubstituted or substituted hydrocarbon aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, or siloxy, where adjacent R1 groups can be joined together to form a fused aromatic ring; Rx is H, F, CN, alkyl, fluoroalkyl, unsubstituted or substituted hydrocarbon aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, siloxy, or R6; Ry is H, F, CN, alkyl, fluoroalkyl, unsubstituted or substituted hydrocarbon aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, siloxy, or R7; R6 and R7 are the same or different and are NH2 ArNH2, or OArNH2; Ar is the same or different at each occurrence and is an unsubstituted or substituted C6-18 hydrocarbon aryl; m and n are the same or different and are an integer from 0-2, such that m + n < 2; x is an integer from 0-4; y and z are the same or different and are an integer from 0 to the maximum available.

  在公式I中：Qa是CRX，SiRx，GeRx，PRX或N；Qb是CRy，SiRy，GeRy，PRy或N；R1、R2和R3在每次出现时相同或不同，并且是F，CN，烷基，氟烷基，未取代或取代的碳氢基芳基，未取代或取代的杂环芳基，烷氧基，氟烷氧基，未取代或取代的芳氧基，硅烷基或硅氧基，其中相邻的R1基团可以结合在一起形成融合的芳香环；Rx是H，F，CN，烷基，氟烷基，未取代或取代的碳氢基芳基，未取代或取代的杂环芳基，烷氧基，氟烷氧基，未取代或取代的芳氧基，硅烷基，硅氧基或R6；Ry是H，F，CN，烷基，氟烷基，未取代或取代的碳氢基芳基，未取代或取代的杂环芳基，烷氧基，氟烷氧基，未取代或取代的芳氧基，硅烷基，硅氧基或R7；R6和R7相同或不同，并且是NH2 ArNH2或OArNH2；Ar在每次出现时相同或不同，并且是未取代或取代的C6-18碳氢基芳基；m和n相同或不同，并且是0-2的整数，使得m + n < 2；x是0-4的整数；y和z相同或不同，并且是0到最大可用的整数。
• Convenient One-Step Synthesis of Benzotriazolylsuccinimides in Melt
  作者：Ivan A. Farion、Dmitrii M. Mognonov、Vitaliy F. Burdukovskii、Bato Ch. Kholkhoev、Petr S. Timashev

  DOI：10.1002/jhet.2557

  日期：2017.3

  maleimides in melt at elevated temperatures has resulted in benzotriazolylsuccinimides. According to spectroscopy data, benzotriazolylsuccinimides obtained contain both major (benzotriazol‐1‐yl)‐succinimide residue and minor (benzotriazol‐2‐yl)‐succinimide residue. An effect of substituents in the initial reagents on the fine splitting of carbon peaks in 13C NMR spectrums of benzotriazolylsuccinimides is discussed

  1H-苯并三唑与马来酰亚胺在高温熔体中的一步相互作用产生了苯并三唑基琥珀酰亚胺。根据光谱数据，所获得的苯并三唑基琥珀酰亚胺包含主要（苯并三唑-1-基）-琥珀酰亚胺残基和次要（苯并三唑-2-基）-琥珀酰亚胺残基。讨论了初始试剂中取代基对苯并三唑基琥珀酰亚胺的13 C NMR光谱中碳峰精细分裂的影响。还讨论了苯并三唑基琥珀酰亚胺的结构对其结晶度的影响。
• Synthesis and Redox Behavior of Dicobalt Complexes Having Flexible and Rigid Linkers
  作者：Hisashi Shimakoshi、Satoshi Hirose、Masaaki Ohba、Takuya Shiga、Hisashi Okawa、Yoshio Hisaeda

  DOI：10.1246/bcsj.78.1040

  日期：2005.6

  New dicobalt complexes, [CoII2L], with Schiff-base ligands (L1–L4) having two discrete metal chelating sites, which are connected to each other by flexible and rigid linkers, have been synthesized. The complexes were characterized by IR, UV–vis, and mass spectroscopy as well as elemental analyses. A magnetic study indicates an antiferromagnetic interaction in 4. The redox behavior of the complexes was examined by means of cyclic voltammetry compared with those of the corresponding mononuclear complexes. Redox waves, identified to CoIII/CoII and CoII/CoI, were clearly observed. Electro-generated [CoI2L]2− reacts with alkyl halide at each metal center to give an organocobalt complex.

  合成了新型双钴配合物 [CoII2L]，其施夫碱配体 (L1–L4) 具有两个独立的金属螯合位点，通过柔性和刚性链连接在一起。通过红外光谱、紫外-可见光谱、质谱以及元素分析对这些配合物进行了表征。磁性研究表明在 4 中存在反铁磁相互作用。通过循环伏安法与相应的一核配合物进行比较，考察了这些配合物的氧化还原行为。明确观察到与 CoIII/CoII 和 CoII/CoI 相对应的氧化还原波。电生成的 [CoI2L]2− 在每个金属中心与烷基卤化物反应，生成有机钴配合物。
• THERMOPLASTIC POLYPHENOXYQUINOXALINE AND METHOD OF PREPARING THE SAME
  申请人：Erdem Haci Bayram

  公开号：US20100048857A1

  公开（公告）日：2010-02-25

  The manufacture of polyetherquinoxalines may be accomplished by polymerization of quinoxaline and related monomers with a bisphenol under aromatic nucleophilic substitution reaction conditions. A method of manufacture includes contacting a substituted or unsubstituted quinoxaline having replaceable groups at the 2,3 positions with a bisphenol or a bisphenol derivative under aromatic nucleophilic substitution reaction conditions. The resulting polyetherquinoxalines contain quinoxaline groups joined by ether linkages at the 2 and 3 positions of the quinoxaline groups. In one example, the polyetherquinoxaline has a formula represented as wherein “n” is an integer from 1 to 10000, and R 1 , R 2 , R 3 , R 4 are independently hydrogen, methyl, CF 3 , tert-butyl, benzoyl, benzenesulfonyl, a sulfonic acid salt, an aliphatic group, an alicyclic group, or an aryl group, and Ar is an aromatic radical. These melt-processable polyetherquinoxalines can be prepared under relatively mild conditions, have excellent thermal and mechanical properties, and are organo-soluble, transparent and colorless thermoplastics.

  聚醚脒并可以通过在芳香亲核取代反应条件下，将喹噁啉及其相关单体与双酚聚合而成。一种制造方法包括在芳香亲核取代反应条件下，将具有可替换基团的取代或未取代的喹噁啉与双酚或双酚衍生物接触。所得的聚醚脒并包含以醚键连接的喹噁啉基团，这些基团位于喹噁啉基团的2和3位置。例如，聚醚脒并具有以下公式：其中“n”是1至10000的整数，R1，R2，R3，R4独立地为氢、甲基、CF3、叔丁基、苯甲酰、苯磺酰、磺酸盐、脂肪基、脂环烷基或芳基，Ar为芳香基团。这些可熔加工的聚醚脒并可以在相对温和的条件下制备，具有优异的热力学和机械性能，是有机溶剂可溶的、透明和无色的热塑性塑料。
• Anionic naphthalene thioureido-diphenyloxides
  申请人：American Cyanamid Company

  公开号：US04096174A1

  公开（公告）日：1978-06-20

  Oxybis-phenylbis-thioureylene tetranaphthalenepoly-sulfonic acid salts, useful as complement inhibitors, and the process for their preparation.

  Oxybis-phenylbis-thioureylene tetranaphthalenepoly-sulfonic acid salts是一种有用的补体抑制剂，其制备过程。