3-(4-甲氧基苯基)色满-6,7-二醇 | 76397-87-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: 3-(4-甲氧基苯基)色满-6,7-二醇
• 英文名称: 3,4-dihydro-6,7-dihydroxy-3-(4-methoxyphenyl)-2H-1-benzopyran
• 英文别名: 6,7-dihydroxy-3-(4-methoxyphenyl)chroman；3,4-dihydro-3-(4-methoxyphenyl)-2H-1-benzopyran-6,7-diol；3-(4-methoxyphenyl)-3,4-dihydro-2H-chromene-6,7-diol
• CAS: 76397-87-0
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: HEMAEFVLALEJDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  二氯二苯甲烷 、 3-(4-甲氧基苯基)色满-6,7-二醇 在 盐酸 、 三乙胺 作用下， 以 吡啶 、 水 为溶剂， 生成 3,4-dihydro-6,7-diphenylmethylenedioxy-3-(4-methoxyphenyl)-2H-1-benzopyran
  参考文献：
  名称：

  Benzopyrans and use thereof in treating vascular diseases

  摘要：

  公式为I ##STR1## 中的异黄酮，其中基团OR、R'、R"和环B的定义如规范中所述，具有有价值的药理特性，特别适用于治疗血管疾病。它们可通过已知的方法制备。

  公开号：

  US04814346A1
• 作为产物：
  描述：

  6,7-二羟基-4-甲氧基异黄酮 在 palladium on activated charcoal 硫酸 、 氢气 、 溶剂黄146 作用下， 反应 14.0h， 以49%的产率得到3-(4-甲氧基苯基)色满-6,7-二醇
  参考文献：
  名称：

  Structure–activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2

  摘要：

  Human lipoxygenase (hLO) isozymes have been implicated in a number of disease states and have attracted much attention with respect to their inhibition. One class of inhibitors, the flavonoids, have been shown to be potent lipoxygenase inhibitors but their study has been restricted to those compounds found in nature, which have limited structural variability. We have therefore carried out a comprehensive study to determine the structural requirements for flavonoid potency and selectivity against platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. We conclude from this study that catechols are essential for high potency, that isoflavones and isoflavanones tend to select against 12-hLO, that isoflavans tend to select against 15-hLO-1, but few flavonoids target 15-hLO-2. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.07.036

文献信息

• Isoflavones and related compounds, methods of preparing and using and
  申请人：Z-L Limited Partnership

  公开号：US04264509A1

  公开（公告）日：1981-04-28

  The present invention concerns isoflavones and related compounds useful as antioxidants and in antioxidant compositions including edible fats and oils. Many of these compounds can be recovered from tempeh, a fermented soybean product. Others can be prepared by chemical modification of those recovered from tempeh. Additionally, all of the compounds can be chemically synthesized. The compounds of the present invention may be used to provide enhanced stability for a wide range of substances subject to oxidative deterioration including edible food products, oils and fats.

  本发明涉及异黄酮和相关化合物，可用作抗氧化剂以及包括可食用脂肪和油在内的抗氧化剂组合物。这些化合物中的许多可以从豆饼中提取出来，豆饼是一种发酵大豆制品。其他化合物可以通过对从豆饼中提取的化合物进行化学修饰而制备。此外，所有化合物都可以通过化学合成获得。本发明的化合物可用于为各种易受氧化恶化的物质提供增强的稳定性，包括可食用食品产品、油和脂肪。
• Bicyclic compounds
  申请人：Zyma SA

  公开号：EP0267155A2

  公开（公告）日：1988-05-11

  Isoflavans of the formula I wherein the groups OR, R', R" and ring B are as defined in the specification, exhibit valueable pharmacological properties, especially for the treatment of vascular diseases. They are prepared by methods known per se.

  式 I 的异黄酮（其中基团 OR、R'、R "和环 B 如说明书中所定义）具有宝贵的药理特性，特别是在治疗血管疾病方面。 它们是通过本身已知的方法制备的。
• CHROMAN AND CHROMANON-4 DERIVATIVES, PROCESS FOR THEIR PREPARATION, ANTIOXIDANT COMPOSITIONS CONTAINING SAME AND THEIR USE FOR STABILIZING EDIBLE FATS AND OILS
  申请人：Z-L LIMITED PARTNERSHIP

  公开号：EP0027796B1

  公开（公告）日：1984-07-11
• ISOFLAVONES AND RELATED COMPOUNDS, METHODS OF PREPARING AND USING AND ANTIOXIDANT COMPOSITIONS CONTAINING SAME
  申请人：Z-L LIMITED PARTNERSHIP

  公开号：EP0027796A1

  公开（公告）日：1981-05-06
• EP0027796A4
  申请人：——

  公开号：EP0027796A4

  公开（公告）日：1981-08-31