ethyl 3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]acrylate | 876169-22-1

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: ethyl 3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]acrylate
• 英文别名: ethyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]prop-2-enoate
• CAS: 876169-22-1
• 化学式: C₁₇H₂₃BO₄
• 分子量: 302.178
• InChiKey: DQKSYIAYDHAHJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]acrylate 在 钯 氢气 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以7.8 g of ethyl 3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propanoate are obtained的产率得到ethyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
  参考文献：
  名称：

  Novel biaromatic compounds that modulate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof

  摘要：

  具有一般式(I)的新型双芳香族化合物及其所含的化妆品/药物组合物在人类或兽医学中（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域）或者在化妆品组合物中是有用的。

  公开号：

  US20080027077A1
• 作为产物：
  描述：

  ethyl 4-bromocinnamate 、 联硼酸频那醇酯 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride potassium acetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以98%的产率得到ethyl 3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]acrylate
  参考文献：
  名称：

  WO2006/53791

  摘要：

  公开号：

文献信息

• Biaromatic compound activators of PPARgamma receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20070207175A1

  公开（公告）日：2007-09-06

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/or of diseases related to the metabolism of lipids) or, alternatively, in cosmetic compositions.

  具有下列一般式（I）的新型双芳香族化合物及其组成的化妆品/药物组合物在人类或兽医学（在皮肤科以及心血管疾病、免疫疾病和/或与脂类代谢相关的疾病领域）中是有用的，或者在化妆品组合物中也是有用的。
• Biaromatic compounds that modulate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US08129416B2

  公开（公告）日：2012-03-06

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有通式（I）的新型双芳香化合物和由此组成的化妆品/药物组合物在人类或兽医学中（在皮肤病学以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域中）非常有用，或者在化妆品中使用。
• NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPARy TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：BOITEAU Jean-Guy

  公开号：US20120121527A1

  公开（公告）日：2012-05-17

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有一般式(I)的新型双芳香族化合物及其所包含的化妆品/药物组合物在人类或兽医学领域（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域）中非常有用，或者在化妆品组合物中使用。
• NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：Galderma Research & Development

  公开号：US20130303549A1

  公开（公告）日：2013-11-14

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有通式(I)的新型双芳香化合物及其所包含的化妆品/药品组合物在人类或兽医医学上具有用途（在皮肤科，以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者在化妆品组合物中也可以使用。
• Biaromatic compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Boiteau Jean-Guy

  公开号：US08513297B2

  公开（公告）日：2013-08-20

  Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.

  具有通式（I）的新型双芳香化合物以及由此组成的化妆品/医药组合物在人类或兽医学（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域）中有用，或者在化妆品组合物中有用。