2-(2-(allyloxy)ethoxy)ethan-1-amine | 106875-68-7

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-(allyloxy)ethoxy)ethan-1-amine
• 英文别名: 2-{2-[(Prop-2-en-1-yl)oxy]ethoxy}ethan-1-amine；2-(2-prop-2-enoxyethoxy)ethanamine
• CAS: 106875-68-7
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: ADVVGPJEJJVXFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(2-(2-azidoethoxy)ethoxy)prop-1-ene 在 三苯基膦 作用下， 以 四氢呋喃 、 水 为溶剂， 以100%的产率得到2-(2-(allyloxy)ethoxy)ethan-1-amine
  参考文献：
  名称：

  装订两个PEG化的侧链可通过熵作用提高WW结构域的构象稳定性

  摘要：

  烃钉合和PEG化是增强肽和蛋白质药物的构象稳定性和/或药代动力学性质的不同策略。在这里，我们通过在β-sheet蛋白WW的两个位置掺入天冬酰胺连接的O-烯丙基PEG低聚物，然后通过烯烃复分解法钉合PEG，来结合这些方法。相对于单独的PEG化作用，装订在一级序列中接近的两个位点的影响较小，并且很大程度上取决于PEG的长度。相比之下，在一级序列中相距遥远但在三级结构中相近的两种PEG的装订则提供了更多的稳定性，这主要是由于熵的作用。聚乙二醇化+钉书钉与钉书钉的比较 在WW的相同位置进行烷基化+钉扎显示，这两种方法都提供了相似的总体构象稳定性水平。

  DOI：

  10.1039/c8ob02535e

文献信息

• MULTIFUNCTIONALIZED SILICON NANOPARTICLES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF IN ELECTROCHEMILUMINESCENCE BASED DETECTION METHODS
  申请人：Roche Diagnostics GmbH

  公开号：EP3504155A1

  公开（公告）日：2019-07-03
• Bifunctional Poly(alkyleneoxides) with Aminoalkyl and Unsaturated Termini and Derivatives Thereof
  申请人：Gelest Technologies, Inc.

  公开号：US20170044316A1

  公开（公告）日：2017-02-16

  A heterofunctional poly(alkyleneoxide) according to the invention contains a first polymer terminus containing a protected, unprotected, or derivatized amine or aminoalkyl functionality and a second polymer terminus containing an unsaturated functionality. Reaction products, derivatives, and methods of making these materials are also described.
• MULTIFUNCTIONALIZED SILICON NANOPARTICLES, PROCESS FOR THEIR PREPARATION AND USES THEREOF IN ELECTROCHEMILUMINESCENCE BASED DETECTION METHODS
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US20220169664A1

  公开（公告）日：2022-06-02

  The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
• [EN] MULTIFUNCTIONALIZED SILICON NANOPARTICLES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF IN ELECTROCHEMILUMINESCENCE BASED DETECTION METHODS<br/>[FR] NANOPARTICULES DE SILICIUM MULTIFONCTIONNALISÉES, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS DANS DES PROCÉDÉS DE DÉTECTION FONDÉS SUR L'ÉLECTROCHIMIOLUMINESCENCE
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2018037060A1

  公开（公告）日：2018-03-01

  The present invention relates to novel multifunctionalized silicon nanopartides, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanopartides. The invention also relates to the use of the novel multifunctionalized silicon nanopartides in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the invention relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanopartides.