白茅素 | 17904-55-1

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 白茅素
• 英文名称: Cylindrin
• 英文别名: (3S,3aS,5aS,5bS,7aR,9S,11aS,13aR,13bS)-9-methoxy-3a,5a,8,8,11a,13a-hexamethyl-3-propan-2-yl-1,2,3,4,5,5b,6,7,7a,9,10,11,13,13b-tetradecahydrocyclopenta[a]chrysene
• CAS: 17904-55-1
• 化学式: C₃₁H₅₂O
• 分子量: 440.7
• InChiKey: MRNPHCMRIQYRFU-UWAWSDATSA-N

物化性质

• 熔点：
  269-270 °C
• 沸点：
  484.9±34.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

制备方法与用途

概述

白茅根为禾本科植物白茅（Imperata cylindrica Beauv. var. major (Nees) C.E.Hubb.)的干燥根茎。春秋两季采挖后，洗净、晒干，除去须根及膜质叶鞘，捆成小把。白茅根最早记载于《神农本草经》，列为中品，并在晋代《肘后备急方》中首次提及炮制方法。该药材性味甘寒，具有凉血止血、清热利尿的功效，常用于治疗吐血、淋病、小便不利、急性肾炎、水肿和黄疸等病症。因其显著疗效而深受历代医家喜爱。随着科技的进步，对白茅根的研究愈发深入。

白茅根的主要化学成分以三萜类化合物为主，包括芦竹素（Arundoin）、白茅素（Cylindrin）、羊齿烯醇（Fernenol）、乔木萜烷（Arborane）、异乔木萜烷（Isoarborinol）、西米杜鹃醇（Simiarenol）、乔木萜醇（Arborinol）、乔木萜醇甲醚（Arborinolmethylether）、乔木萜酮（Arborinone）和木栓酮（Friedelin）等，同时含有可溶性钙。

应用

白茅素具有降血压活性。研究中，将9～12周龄的自发性高血压大鼠(SHR)按血压分组，并进行不同剂量的给药试验，连续经口给药7天后测量尾动脉血压。结果显示：白茅素能有效降低SHR大鼠的血压，与模型对照组相比存在显著差异。

文献信息

• AN COMPOSITION CONTAINING TRITERPENOID SAPONINS EXTRACTED FROM BAMBOO, AND THE PREPARATION METHOD AND USE THEREOF
  申请人：Zhejiang University (Hangzhou) Leaf Bio-Technology Co., Ltd.

  公开号：EP1576958A1

  公开（公告）日：2005-09-21

  The invention relates to a composition containing total triterpenoid sapogenins extracted from bamboo, the preparation method and use thereof. These total triterpenoid sapogenins are extracted from many parts of bamboo such as bamboo shavings in Gramineae by CO2 Supercritical Fluid Extraction technique. In the extract, the content of total triterpenoid sapogenins is 10-90%, while the contents of friedelin and lupenone are 5-35% and 1-10%, respectively. The extract in the invention has good physiological and pharmacological activities such as anti-free radical, anti-oxidation, anti-tumor and anti-hypertension. It can be used in medicines or functional foods for the treatment or prevention of cardiovascular and cerebrovascular diseases and tumor. It is also useful in cosmetics field.

  本发明涉及一种含有从竹子中提取的总三萜类苷元的组合物及其制备方法和用途。这些总三萜苷元是通过二氧化碳超临界流体萃取技术从竹子的许多部分（如禾本科竹屑）中提取出来的。在提取物中，总三萜苷元的含量为 10-90%，而油菜素和羽扇豆酮的含量分别为 5-35%和 1-10%。本发明中的提取物具有良好的生理和药理活性，如抗自由基、抗氧化、抗肿瘤、抗高血压等。它可用于治疗或预防心脑血管疾病和肿瘤的药物或功能性食品中。它还可用于化妆品领域。
• Antistress composition for a stress prevention and treatment
  申请人：Byung Hag Choi

  公开号：US20020054920A1

  公开（公告）日：2002-05-09

  The present invention provides antistress compositions contaning various medicinal herbs which are composed of one or more of medicinal herb 2.0˜40.0 g of fructus hordel germintus, messa medicata fermentata, frucutus amomi and fructus crataegei; hone or more of medicinal herb 2.0˜40.0 g of radix polygalae, semen zizyphi spinosae and rhizoma acori graminei; one or more of medicinal herb 2.0˜40.0 g selected from the group of poria holen and poria, one or more of medicinal herb 2.0˜40.0 g of folium phyllostachyos, calus in taein phyllostachos, succus phyllostachos and radix scutellariae; one or more of medicinal herb 2.0˜40.0 g of legumonosae, fructus amomicardamomi, semen glycine and semen lablab; one or more of medicinal herb 2.0˜40.0 g of rhizoma zingiberis, radix asari, rhizoma zingiberis siccatum and radix aconiti; one or more of medicinal herb 2.0˜40.0 g of bulbos allii fistulosi, herba ephedrae and folium perillae; and one or more of medicinal herb 2.0˜40.0 g of red pepper and radix platycodi as the effective ingredients that relieve stress and represse of a memory failure that releive stress and repress of a memory failure.

  本发明提供了含有多种药材的抗抑郁组合物，这些药材由以下一种或多种药材组成 2.0 ˜40.0 克 枸杞子、枸杞子酵母、枸杞子杏仁 和 枸杞子； 一种或多种药材 2.0 ˜40.0 克，包括 远志、酸枣仁 和 一种或多种 选自以下组别的一种或多种药材 2.0˜40.0 克 茯苓 和茯苓中的一种或多种药材 2.0˜40.0 克 一种或多种药材 2.0˜40.0 克，选自茯苓和茯苓组；一种或多种药材 2.0˜40.0 克，选自茯苓叶、茯苓茎、茯苓肉 和 黄芩； 一种或多种药材 2.0 ˜40.0 克豆科植物、 枸杞子、甘氨酸精液 和 一种或多种 一种或多种药材 2.0˜40.0 克 一种或多种药材 2.0˜40.0克 和 乌头； 一种或多种药材 2.0˜40.0g，包括 一种或多种药材 2.0˜40.0 克 和 folium perillae； 红辣椒和桔梗中的一种或多种药材 2.0˜40.0g；以及 桔梗 作为有效成分，可缓解压力和记忆力衰退，释放压力和抑制记忆力衰退。
• AMYLOID PEPTIDE VARIANTS
  申请人：Loyola Marymount University

  公开号：EP3927725A1

  公开（公告）日：2021-12-29
• Chinese traditional medicines for psoriasis
  申请人：——

  公开号：US20030152588A1

  公开（公告）日：2003-08-14

  The invention relates to disclose some Chinese formula for psoriasis. Whether treatment for psoriasis is targeted at both the hyperproliferative and inflammatory aspect of the topical therapy. Specially, the administration dosage is soft gel, cream, tincture and aerosol etc. topical dosages.
• Composition containing total triterpenoid saponins extracted from bamboo, and the preparation method and use thereof
  申请人：Zhang Ying

  公开号：US20060148733A1

  公开（公告）日：2006-07-06

  The invention relates to a composition containing total triterpenoid sapogenins extracted from bamboo, the preparation method and use thereof. These total triterpenoid sapogenins are extracted from many parts of bamboo such as bamboo shavings in Gramineae by CO 2 Supercritical Fluid Extraction technique. In the extract, the content of total triterpenoid sapogenins is 10-90%, while the contents of friedelin and lupenone are 5-35% and 1-10%, respectively. The extract in the invention has good physiological and pharmacological activities such as anti-free radical, anti-oxidation, anti-tumor and anti-hypertension. It can be used in medicines or functional foods for the treatment or prevention of cardiovascular and cerebrovascular diseases and tumor. It is also useful in cosmetics field.

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