Taxa-4 (20),11(12)-dien-10β-tert-butyldimethylsilyloxy-2α, 14β-di-S-methyldithiocarboxy-5α-ol | 444578-22-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Taxa-4 (20),11(12)-dien-10β-tert-butyldimethylsilyloxy-2α, 14β-di-S-methyldithiocarboxy-5α-ol
• 英文别名: O-[(1S,2S,3S,5S,8S,10S,14S)-10-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylidene-2-methylsulfanylcarbothioyloxy-14-tricyclo[9.3.1.03,8]pentadec-11-enyl] methylsulfanylmethanethioate
• CAS: 444578-22-7
• 化学式: C₃₀H₅₀O₄S₄Si
• 分子量: 631.074
• InChiKey: DCUPMXLNVBNHQQ-MGVBRZMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.54
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  163
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Taxa-4 (20),11(12)-dien-10β-tert-butyldimethylsilyloxy-2α, 14β-di-S-methyldithiocarboxy-5α-ol 在 4-二甲氨基吡啶 、 偶氮二异丁腈 、 四丁基氟化铵 、 三正丁基氢锡 作用下， 以 四氢呋喃 、 吡啶 、 甲苯 为溶剂， 反应 507.0h， 生成 紫杉醇杂质15(TAXADIENE-5-ALPHA-ACETOXY-10-BETA-OL)
  参考文献：
  名称：

  Studies on Taxol Biosynthesis. Preparation of Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol by Deoxygenation of a Taxadiene Tetraacetate Obtained from Japanese Yew

  摘要：

  Taxa-4(20),11(12)-dien-5alpha-acetoxy-10beta-ol 6 has been identified as an early stage intermediate involved in the biosynthesis of taxol (Paclitaxel). This compound has been efficiently prepared by Barton deoxygenation of the C-2- and C-14-hydroxyl groups on a derivative semisynthetically prepared from taxa-4(20),11(12)-dien-2alpha,5alpha,10beta-triacetoxy-14beta-(2-methyl)butyrate (7), a major taxoid metabolite isolated from Japanese yew heart wood. The synthetic methodology is amenable for the preparation of isotopically labeled congeners that will be useful to probe further intermediate steps in the biosynthesis of taxol.

  DOI：

  10.1021/jo025679z
• 作为产物：
  描述：

  2,5,10,14-desacetyl taxuyunnanine C 在 咪唑 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 148.34h， 生成 Taxa-4 (20),11(12)-dien-10β-tert-butyldimethylsilyloxy-2α, 14β-di-S-methyldithiocarboxy-5α-ol
  参考文献：
  名称：

  Studies on Taxol Biosynthesis. Preparation of Taxa-4(20),11(12)-dien-5α-acetoxy-10β-ol by Deoxygenation of a Taxadiene Tetraacetate Obtained from Japanese Yew

  摘要：

  Taxa-4(20),11(12)-dien-5alpha-acetoxy-10beta-ol 6 has been identified as an early stage intermediate involved in the biosynthesis of taxol (Paclitaxel). This compound has been efficiently prepared by Barton deoxygenation of the C-2- and C-14-hydroxyl groups on a derivative semisynthetically prepared from taxa-4(20),11(12)-dien-2alpha,5alpha,10beta-triacetoxy-14beta-(2-methyl)butyrate (7), a major taxoid metabolite isolated from Japanese yew heart wood. The synthetic methodology is amenable for the preparation of isotopically labeled congeners that will be useful to probe further intermediate steps in the biosynthesis of taxol.

  DOI：

  10.1021/jo025679z