3,3'-methylenebis<2-(diethylamino)-7-ethoxychromone> | 131942-63-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 3,3'-methylenebis<2-(diethylamino)-7-ethoxychromone>
• 英文别名: 2-(diethylamino)-3-[[2-(diethylamino)-7-ethoxy-4-oxochromen-3-yl]methyl]-7-ethoxychromen-4-one
• CAS: 131942-63-7
• 化学式: C₃₁H₃₈N₂O₆
• 分子量: 534.653
• InChiKey: MWDVIVHQIPQRBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.98
• 重原子数：
  39.0
• 可旋转键数：
  12.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  85.36
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  3,3'-methylenebis<2-(diethylamino)-7-ethoxychromone> 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以62.6%的产率得到4,4'-methylenbis<3-(diethylamino)-5-(2-hydroxy-4-ethoxyphenyl)isoxazole>
  参考文献：
  名称：

  Synthesis of new 3,5-disubstituted isoxazoles with specific anti-group B rhinovirus activity in vitro

  摘要：

  3,5-Disubstituted isoxazoles 4a-f were synthesized as potential anti-rhinovirus agents. These compounds were prepared in good yield by treatment of the corresponding 2-(dialkylamino)chromones 3a-f with hydroxylamine. Compounds 4 were demethylated to obtain dihydroxyderivatives 5, which were then transformed in acetyl-6 and alkylderivatives 7. The methylenbisderivatives 9 were obtained by reaction of bischromones 8 with hydroxylamine. Most compounds were subjected to antiviral screening. Compounds 4c, 7a, 7b and 7c were found to be specific inhibitors of group B rhinoviruses.

  DOI：

  10.1016/0223-5234(93)90025-a
• 作为产物：
  描述：

  3-乙氧基苯酚 在 乙酸酐 、 溶剂黄146 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 15.0h， 生成 3,3'-methylenebis<2-(diethylamino)-7-ethoxychromone>
  参考文献：
  名称：

  Synthesis and antiplatelet activity of 2-(diethylamino)-7-ethoxychromone and related compounds

  摘要：

  DOI：

  10.1016/0223-5234(90)90187-8

文献信息

• MAZZEI, M.;SOTTOFATTORI, E.;DI, BRACCIO M.;BALBI, A.;LEONCINI, G.;BUZZI, +, EUR. J. MED. CHEM., 25,(1990) N, C. 617-622
  作者：MAZZEI, M.、SOTTOFATTORI, E.、DI, BRACCIO M.、BALBI, A.、LEONCINI, G.、BUZZI, +

  DOI：——

  日期：——