2-二乙基氨基-7-乙氧基苯并吡喃-4-酮 | 131942-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 2-二乙基氨基-7-乙氧基苯并吡喃-4-酮
• 英文名称: 2-(diethylamino)-7-etoxychromone
• 英文别名: 2-(Diethylamino)-7-ethoxychromone；2-(diethylamino)-7-ethoxychromen-4-one
• CAS: 131942-55-7
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: QAHJXTVDICVNRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-二乙基氨基-7-乙氧基苯并吡喃-4-酮 在 tetraphosphorus decasulfide 作用下， 以 吡啶 为溶剂， 反应 1.0h， 以77.3%的产率得到2-(diethylamino)-7-ethoxy-4-thiochromone
  参考文献：
  名称：

  Synthesis and antiplatelet activity of 2-(diethylamino)-7-ethoxychromone and related compounds

  摘要：

  DOI：

  10.1016/0223-5234(90)90187-8
• 作为产物：
  描述：

  间苯二酚 在 sodium hydroxide 、 三氯氧磷 作用下， 反应 9.5h， 生成 2-二乙基氨基-7-乙氧基苯并吡喃-4-酮
  参考文献：
  名称：

  Synthesis and antiplatelet activity of 2-(diethylamino)-7-ethoxychromone and related compounds

  摘要：

  DOI：

  10.1016/0223-5234(90)90187-8

文献信息

• Synthesis of new 3,5-disubstituted isoxazoles with specific anti-group B rhinovirus activity in vitro
  作者：M Mazzei、A Balbi、E Sottofattori、R Garzoglio、A De Montis、S Corrias、P La Colla

  DOI：10.1016/0223-5234(93)90025-a

  日期：1993.1

  3,5-Disubstituted isoxazoles 4a-f were synthesized as potential anti-rhinovirus agents. These compounds were prepared in good yield by treatment of the corresponding 2-(dialkylamino)chromones 3a-f with hydroxylamine. Compounds 4 were demethylated to obtain dihydroxyderivatives 5, which were then transformed in acetyl-6 and alkylderivatives 7. The methylenbisderivatives 9 were obtained by reaction of bischromones 8 with hydroxylamine. Most compounds were subjected to antiviral screening. Compounds 4c, 7a, 7b and 7c were found to be specific inhibitors of group B rhinoviruses.
• MAZZEI, M.;SOTTOFATTORI, E.;DI, BRACCIO M.;BALBI, A.;LEONCINI, G.;BUZZI, +, EUR. J. MED. CHEM., 25,(1990) N, C. 617-622
  作者：MAZZEI, M.、SOTTOFATTORI, E.、DI, BRACCIO M.、BALBI, A.、LEONCINI, G.、BUZZI, +

  DOI：——

  日期：——
• Synthesis and antiplatelet activity of 2-(diethylamino)-7-ethoxychromone and related compounds
  作者：M Mazzei、E Sottofattori、M Di Braccio、A Balbi、G Leoncini、E Buzzi、M Maresca

  DOI：10.1016/0223-5234(90)90187-8

  日期：1990.9