摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

羟乙桂胺 | 6961-46-2

中文名称
羟乙桂胺
中文别名
——
英文名称
N-(Hydroxy-2-aethyl)-cinnamid
英文别名
N-(2-Hydroxyethyl)cinnamamid;N-(2-hydroxyethyl)cinnamamide;N-(2-Hydroxyethyl)-3-phenyl-2-propenamide;N-(2-hydroxyethyl)-3-phenylprop-2-enamide
羟乙桂胺化学式
CAS
6961-46-2
化学式
C11H13NO2
mdl
——
分子量
191.23
InChiKey
OSCTXCOERRNGLW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    100-102°
  • 溶解度:
    可溶于氯仿(轻微,超声处理),甲醇(轻微)

计算性质

  • 辛醇/水分配系数(LogP):
    0.9
  • 重原子数:
    14
  • 可旋转键数:
    4
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.18
  • 拓扑面积:
    49.3
  • 氢给体数:
    2
  • 氢受体数:
    2

SDS

SDS:a4b726f461a4502efaa65ccbcd6f38db
查看

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    羟乙桂胺氢气 作用下, 以 甲醇 为溶剂, 反应 5.0h, 以96%的产率得到N-(2-hydroxyethyl)-3-phenylpropanamide
    参考文献:
    名称:
    硅藻土-聚苯胺负载的钯催化剂用于化学选择性加氢反应
    摘要:
    涂覆在硅藻土颗粒上的聚苯胺被用作负载钯催化剂的载体。这种杂化的Celite•PANI•Pd系统被用作化学选择性氢化反应的有效催化剂。该催化剂通过常用的光谱,分析技术进行表征,并针对环境条件下的氢化反应进行了研究。温和的反应条件可以控制反应,并在转化数上实现出色的选择性。碳-碳双键的氢化作用优于其他极性π-键系统,而不稳定的官能团(如苄基醚,苄基酯,氰基,硝基和卤素)不受影响。伯胺被转化为N,N‐二甲基胺与甲醛,香豆素的双键被选择性地氢化而不打开内酯官能团。
    DOI:
    10.1002/aoc.4767
  • 作为产物:
    描述:
    肉桂酸三乙胺 作用下, 以 二氯甲烷 为溶剂, 反应 2.0h, 生成 羟乙桂胺
    参考文献:
    名称:
    Synthesis and antidepressant-like action of N-(2-hydroxyethyl) cinnamamide derivatives in mice
    摘要:
    This study described the chemical synthesis and pharmacological evaluation of a series of N-(2-hydroxyethyl) cinnamamide derivatives. The structures of them were characterized by IR, (1)H-NMR, MS and elemental analysis. Their antidepressant activities were evaluated by the forced swimming test (FST) and tail suspension test (TST). Pharmacological results of these compounds showed that some of them, given orally, significantly reduced the immobility time in the FST and TST, indicating the antidepressant-like action. Among them, compounds N-(2-hydroxyethyl)cinnamamide (1g), (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-hydroxyethyl)acrylamide (1i) and (E)-N-(2-hydroxyethyl)-3-(3-hydroxyphenyl)acrylamide (1n), active in the two models, were considered as the most promising compounds in this study.
    DOI:
    10.1007/s00044-010-9470-7
点击查看最新优质反应信息

文献信息

  • Nitric Oxide Releasing Prodrugs of Therapeutic Agents
    申请人:SATYAM Apparao
    公开号:US20110263526A1
    公开(公告)日:2011-10-27
    The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.
    本发明涉及已知药物或治疗剂的一氧化氮释放前药,其在此处表示为式(I)的化合物,其中药物或治疗剂包含一个或多个功能基团,独立地选自羧酸基、羟基和巯基。该发明还涉及制备一氧化氮释放前药(式(I)的化合物)的方法,含有它们的药物组合物以及使用这些前药的方法。
  • N-Heterocyclic carbene (NHC) catalyzed chemoselective acylation of alcohols in the presence of amines with various acylating reagents
    作者:Ramesh C. Samanta、Suman De Sarkar、Roland Fröhlich、Stefan Grimme、Armido Studer
    DOI:10.1039/c3sc00099k
    日期:——
    subsequent acylation step. NHC-catalyzed selective acylation of benzyl alcohol in the presence of benzylamine can also be achieved with trifluoroethyl and hexafluoroisopropylesters as acylation reagents. Moreover, an enol acetate also shows high O-selectivity as a chemoselective acetylation reagent. Kinetic and mechanistic studies are provided and some examples of the chemoselective acylation of amino
    这篇前沿文章报道了三种不同的酰基唑鎓离子的合成和完整表征,包括X射线分析。讨论了这些酰基la离子作为胺和醇的酰化试剂的反应性。然而苄胺与酰基唑鎓离子缓慢反应,不会发生苯甲醇酰化反应。然而,在用N-杂环卡宾(NHC)作为催化剂活化醇时,实现了有效的酯化。重要的是,苄基酯的形成是在以下条件下获得的:苄胺由NHC选择性酒精激活后。高平的DFT计算表明,酒精的活化是通过NHC与酒精之间的强H键形成而发生的,从而增加了酒精的亲核性。对于在NHC催化下氧化生成的酰基la离子而言,卡宾具有双重作用(协同催化):(a)NHC用于生成酰基zo离子,(b)NHC用于在随后的酰化反应中活化醇步。NHC催化的苯甲酰选择性酰化苯甲醇 在......的存在下 苄胺用三乙基和六异丙基酯作为酰化剂也可以实现。而且,烯醇乙酸酯作为化学选择乙酰化试剂也显示出高的O-选择性。提供了动力学和机理研究,并提供了基醇化学选择性酰化的一些实例。
  • Technology for the Preparation of Microparticles
    申请人:Malakhov Michael
    公开号:US20090098207A1
    公开(公告)日:2009-04-16
    Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
    微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触,并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
  • Compositions and methods to effect the release profile in the transdermal administration of active agents
    申请人:——
    公开号:US20020004065A1
    公开(公告)日:2002-01-10
    Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.
    本发明涉及一种用于经皮递送活性药剂的组合物和方法,该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂,包括一种药学上可接受的粘合基质和一种聚合物塑料材料,该聚合物塑料材料对活性药剂具有释放速率调节作用。
  • Diagnostic/therapeutic agents
    申请人:Klaveness Jo
    公开号:US20050002865A1
    公开(公告)日:2005-01-06
    Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
    可定位的诊断和/或治疗活性剂,例如超声对比剂,包括悬浮在载体液中的报告物,该报告物包含含气体或生成气体的材料,该剂能够与目标形成至少两种结合对。
查看更多