cannabidivarin | 24274-48-4

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: cannabidivarin
• 英文别名: 2-[(1S,6S)-6-isopropenyl-3-methyl-1-cyclohex-2-enyl]-5-propyl-benzene-1,3-diol；2-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)-5-propylbenzene-1,3-diol
• CAS: 24274-48-4
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.414
• InChiKey: REOZWEGFPHTFEI-UHFFFAOYSA-N

物化性质

• 沸点：
  439.4±45.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)
• 闪点：
  9℃

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• WGK Germany：
  1
• 储存条件：
  -20℃

反应信息

• 作为反应物：
  描述：

  cannabidivarin 在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 25.0~50.0 ℃ 、500.01 kPa 条件下， 生成 2-(5-Methyl-2-propan-2-ylcyclohexyl)-5-propylbenzene-1,3-diol
  参考文献：
  名称：

  WO2023/4414

  摘要：

  公开号：

文献信息

• [EN] COMPOSITIONS COMPRISING CANNABINOID IONS DISSOLVING IN GLYCEROL<br/>[FR] COMPOSITIONS COMPRENANT DES IONS CANNABINOÏDES DISSOUS DANS DU GLYCÉROL
  申请人：NATURAL EXTRACTION SYS LLC

  公开号：WO2021041637A1

  公开（公告）日：2021-03-04

  Various aspects of this patent document relate to cannabinoid ions that are dissolved in glycerol, in which the cannabinoid ions are not carboxylates.

  这个专利文件的各个方面涉及到在甘油中溶解的大麻素离子，其中大麻素离子不是羧酸盐。
• FOOD AND BEVERAGE COMPOSITIONS INFUSED WITH LIPOPHILIC ACTIVE AGENTS AND METHODS OF USE THEREOF
  申请人：Poviva Corp.

  公开号：EP3858364A1

  公开（公告）日：2021-08-04

  Aspects described herein relate to food and beverage compositions infused with lipophilic active agents and methods of use for the treatment of a variety of disorders. More particularly, aspects described herein relate to food and beverage compositions infused with lipophilic active agents such as cannabinoids, nicotine, nonsteroidal anti-inflammatories (NSAIDs), and vitamins, that provide enhanced bioavailability of the lipophilic active agents in a subject, and that mask unpleasant tastes of lipophilic active agents.

  本文所述方面涉及注入亲脂性活性剂的食品和饮料组合物以及用于治疗各种疾病的方法。更具体地说，本文所述方面涉及注入亲脂性活性剂（如大麻素、尼古丁、非甾体抗炎药（NSAIDs）和维生素）的食品和饮料组合物，该组合物可提高亲脂性活性剂在受试者体内的生物利用率，并可掩盖亲脂性活性剂的难闻味道。
• USE OF CANNABIDIOL IN THE TREATMENT OF SEIZURES ASSOCIATED WITH DOOSE SYNDROME
  申请人：GW Research Limited

  公开号：EP3888641A1

  公开（公告）日：2021-10-06

  The present disclosure relates to the use of cannabidiol (CBD) for the treatment of of nocturnal snoring. In particular the CBD appears particularly effective in treating nocturnal snoring in children and young adults with epilepsy The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).

  本公开涉及使用大麻二酚（CBD）治疗夜间打鼾。本公开还涉及大麻二酚与一种或多种抗癫痫药物（AEDs）联合使用。
• USE OF CANNABIDIOL FOR THE TREATMENT OF FOCAL SEIZURES IN DRAVET SYNDROME
  申请人：GW Research Limited

  公开号：EP3984531A1

  公开（公告）日：2022-04-20

  The present invention relates to the use of cannabidiol (CBD) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults. CBD appears particularly effective in reducing focal seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; CDKL5; Neuronal ceroid lipofuscinoses (NCL); febrile infection related epilepsy syndrome (FIRES); Aicardi syndrome and brain abnormalities in comparison to other seizure types. Significantly CBD additionally is very effective in the reduction of a sub-type of focal seizures, focal seizures with impairment.

  本发明涉及使用大麻二酚（CBD）治疗局灶性癫痫发作。在一个实施方案中，局灶性癫痫发作的患者是儿童和青少年。大麻二酚似乎对减少病因包括以下病因的患者的局灶性癫痫发作特别有效：这些病因包括：伦诺克斯-加斯陶特综合征；结节性硬化综合征；德拉沃综合征；CDKL5；神经细胞类脂质沉着病（NCL）；发热感染相关癫痫综合征（FIRES）；艾卡迪综合征以及与其他发作类型相比的大脑异常。值得注意的是，CBD 还能有效减少局灶性癫痫发作的一种亚型，即局灶性癫痫发作伴有损伤。
• Prenyltransferase variants with increased thermostability
  申请人：INVIZYNE TECHNOLOGIES, INC.

  公开号：US11518983B1

  公开（公告）日：2022-12-06

  The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.

  本公开涉及具有更高热稳定性和活性的重组炔基转移酶，以及这些酶在涉及炔基 化反应的生物合成的组合物和方法中的用途，包括制备大麻素的组合物和方法。