pectenotoxin-6 | 124843-18-1

• 物质功能分类: 食品添加剂 - 增稠剂
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: pectenotoxin-6
• 英文别名: pectenotoxin 7 | PTX 7；(1S,2R,5R,7R,8E,10E,12R,14S,16R,19R,20S,24R,27S,28S,29R,32R,33R,35S)-14-[(2S,3R,4R)-2,3-dihydroxy-4-methyloxan-2-yl]-28-hydroxy-5,7,9,19,29-pentamethyl-18,31-dioxo-13,17,38,39,40,41,42,43-octaoxaoctacyclo[31.4.1.11,35.12,5.120,24.124,27.129,32.012,16]tritetraconta-8,10-diene-35-carboxylic acid
• CAS: 124843-18-1
• 化学式: C₄₇H₆₈O₁₆
• 分子量: 889.047
• InChiKey: IJSPTHZVVHPQQN-GFWDZPHRSA-N

物化性质

• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.32
• 重原子数：
  63.0
• 可旋转键数：
  2.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  215.2
• 氢给体数：
  4.0
• 氢受体数：
  15.0

制备方法与用途

概述

苹果果胶是从苹果渣中提取的高分子多糖类物质，相对分子质量在1万～40万u之间，主要由以α-1,4-糖苷键相连的多聚半乳糖醛酸链构成。

生物活性

苹果果胶是膳食纤维的一种，也是苹果中的活性成分之一。虽然国外对其生物活性的研究较多，但国内研究较少。现代生物学与医学研究表明，苹果果胶具有抗氧化、降血脂、抗菌以及预防结肠癌和前列腺癌等功效。

应用

苹果果胶是一种完全无毒的天然食品添加剂，广泛应用于食品工业中，主要作为凝胶剂、稳定剂和增稠剂，可以显著提高食品品质。保健食品中通常含有被称作苹果果胶D的颗粒状物质，每粒（10毫克）中的果胶含量相当于6～7个苹果的果胶含量。

简介

研究人员发现，在苹果中含有大量的果胶，这种物质对导致癌症等多种疾病的活性氧具有明显的抑制作用。该产品是将苹果榨汁后的剩余物干燥、煮沸后从中提取出高浓度的果胶汁，并使之固化产生出来的。

用途

果胶作为高档的天然食品添加剂和保健品，在食品上可用作胶凝剂、增稠剂、稳定剂、悬浮剂、乳化剂和增香增效剂；在医药保健品中则能显著降低血糖、血脂，减少胆固醇，疏通血管。它对糖尿病、高血压、便秘以及铅中毒等疾病具有明显疗效，并且可用于化妆品中，有助于保护皮肤、防止紫外线辐射、治疗伤口及美容养颜。

果胶通常是白色至淡黄色粉末，带有轻微的酸味，并可溶于水。

反应信息

• 作为反应物：
  描述：

  pectenotoxin-6 在 三氟乙酸 作用下， 以 水 、 乙腈 为溶剂， 反应 48.0h， 以35%的产率得到pectenotoxin 9
  参考文献：
  名称：

  Identification and Characterization of Pectenotoxin (PTX) 4 and PTX7 as Spiroketal Stereoisomers of Two Previously Reported Pectenotoxins

  摘要：

  Pectenotoxins (PTXs) isolated from the scallop Patinopecten yessoensis were shown to be involved in an episode of diarrhetic shellfish poisoning (DSP). A total of eight analogues (PTX1-PTX7 and PTX10) have been isolated to date, and the structures of four of these analogues (PTX1, PTX2, PTX3, and PTX6) have already been elucidated. Here, we report the characterization of PTX4 and PTX7 as 7-epi-PTX1 and 7-epi-PTX6, respectively, on the basis of NMR data and an acid-catalyzed chemical interconversion. The structures of two new artifacts, PTX8 and PTX9, produced following this treatment are also reported.

  DOI：

  10.1021/jo971310b
• 作为产物：
  描述：

  pectenotoxin-6 以 水 、 乙腈 为溶剂， 生成 pectenotoxin-6
  参考文献：
  名称：

  Identification and Characterization of Pectenotoxin (PTX) 4 and PTX7 as Spiroketal Stereoisomers of Two Previously Reported Pectenotoxins

  摘要：

  Pectenotoxins (PTXs) isolated from the scallop Patinopecten yessoensis were shown to be involved in an episode of diarrhetic shellfish poisoning (DSP). A total of eight analogues (PTX1-PTX7 and PTX10) have been isolated to date, and the structures of four of these analogues (PTX1, PTX2, PTX3, and PTX6) have already been elucidated. Here, we report the characterization of PTX4 and PTX7 as 7-epi-PTX1 and 7-epi-PTX6, respectively, on the basis of NMR data and an acid-catalyzed chemical interconversion. The structures of two new artifacts, PTX8 and PTX9, produced following this treatment are also reported.

  DOI：

  10.1021/jo971310b

文献信息

• Identification and Characterization of Pectenotoxin (PTX) 4 and PTX7 as Spiroketal Stereoisomers of Two Previously Reported Pectenotoxins
  作者：Katsunori Sasaki、Jeffrey L. C. Wright、Takeshi Yasumoto

  DOI：10.1021/jo971310b

  日期：1998.4.1

  Pectenotoxins (PTXs) isolated from the scallop Patinopecten yessoensis were shown to be involved in an episode of diarrhetic shellfish poisoning (DSP). A total of eight analogues (PTX1-PTX7 and PTX10) have been isolated to date, and the structures of four of these analogues (PTX1, PTX2, PTX3, and PTX6) have already been elucidated. Here, we report the characterization of PTX4 and PTX7 as 7-epi-PTX1 and 7-epi-PTX6, respectively, on the basis of NMR data and an acid-catalyzed chemical interconversion. The structures of two new artifacts, PTX8 and PTX9, produced following this treatment are also reported.