| 190778-73-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 190778-73-5
• 化学式: C₅₉H₇₇NO₁₈Si₂
• 分子量: 1144.43
• InChiKey: NHQDENMHPLXGPU-SDXTULIHSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 、 双氧水 、 碳酸氢钠 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 iso-docetaxel
  参考文献：
  名称：

  Structure-activity relationships study at the 3′-N position of paclitaxel-part 1: Synthesis and biological evaluation of the 3′-(t)-butylaminocarbonyloxy bearing paclitaxel analogs

  摘要：

  An efficient syntheses of the 3'-N isomeric paclitaxel analogs, 4 and 5, are described. A highly diastereoselective Sharpless asymmetric dihydroxylation reaction is utilized to establish the required (2'R, 3'S) stereochemistry on the C-13 side chain. Both of the 3'-N modified analogs 4 and 5 were found to be cytotoxic in vitro. Analog 4 also displayed comparable in vivo activity to that of paclitaxel in the ip M-109 tumor model. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10142-1
• 作为产物：
  描述：

  在 咪唑 、 potassium osmate(VI) 、 N-甲基吲哚酮 、 Hydroquinone 1,4-phthalazinediyl diether 、 N-乙基二丙胺 、 叔丁醇 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Structure-activity relationships study at the 3′-N position of paclitaxel-part 1: Synthesis and biological evaluation of the 3′-(t)-butylaminocarbonyloxy bearing paclitaxel analogs

  摘要：

  An efficient syntheses of the 3'-N isomeric paclitaxel analogs, 4 and 5, are described. A highly diastereoselective Sharpless asymmetric dihydroxylation reaction is utilized to establish the required (2'R, 3'S) stereochemistry on the C-13 side chain. Both of the 3'-N modified analogs 4 and 5 were found to be cytotoxic in vitro. Analog 4 also displayed comparable in vivo activity to that of paclitaxel in the ip M-109 tumor model. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10142-1