3-(2,5-Dimethoxy-4-methyl-phenyl)-2,2,3-trimethyl-cyclopentanol | 878774-38-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-(2,5-Dimethoxy-4-methyl-phenyl)-2,2,3-trimethyl-cyclopentanol
• 英文别名: 3-(2,5-Dimethoxy-4-methylphenyl)-2,2,3-trimethylcyclopentan-1-ol
• CAS: 878774-38-0
• 化学式: C₁₇H₂₆O₃
• 分子量: 278.392
• InChiKey: GFAQBCGEDMBAGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2,5-Dimethoxy-4-methyl-phenyl)-2,2,3-trimethyl-cyclopentanol 在 silica gel 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以96%的产率得到2,2,3-trimethyl-3-(2,5-dimethoxy-4-methylphenyl)cyclopentan-1-one
  参考文献：
  名称：

  The first total synthesis of (±)-lagopodin A

  摘要：

  The first total synthesis of (+/-)-lagopodin A and a formal total synthesis of enokipodins A and B is described. The requisite precursors containing two vicinal quaternary carbon atoms were assembled employing Claisen rearrangement and an RCM reaction as key steps starting from 2,5-dimethoxy-4-methylacetophenone. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.12.071
• 作为产物：
  描述：

  2-Allyl-2-(2,5-dimethoxy-4-methyl-phenyl)-3,3-dimethyl-pent-4-enoic acid methyl ester 在 氢氧化钾 、 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 Grubbs catalyst first generation 、 三氟化硼乙醚 、 silica gel 、 一水合肼 、 pyridinium chlorochromate 、 二乙二醇 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 23.5h， 生成 3-(2,5-Dimethoxy-4-methyl-phenyl)-2,2,3-trimethyl-cyclopentanol
  参考文献：
  名称：

  The first total synthesis of (±)-lagopodin A

  摘要：

  The first total synthesis of (+/-)-lagopodin A and a formal total synthesis of enokipodins A and B is described. The requisite precursors containing two vicinal quaternary carbon atoms were assembled employing Claisen rearrangement and an RCM reaction as key steps starting from 2,5-dimethoxy-4-methylacetophenone. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.12.071

文献信息

• The first total synthesis of (±)-lagopodin A
  作者：A. Srikrishna、B. Vasantha Lakshmi、P.C. Ravikumar

  DOI：10.1016/j.tetlet.2005.12.071

  日期：2006.2

  The first total synthesis of (+/-)-lagopodin A and a formal total synthesis of enokipodins A and B is described. The requisite precursors containing two vicinal quaternary carbon atoms were assembled employing Claisen rearrangement and an RCM reaction as key steps starting from 2,5-dimethoxy-4-methylacetophenone. (c) 2006 Elsevier Ltd. All rights reserved.