异噻唑啉酮 | 55965-84-9

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 异噻唑啉酮
• 中文别名: 凯松防腐剂；5-氯-2-甲基-1-异噻唑啉-3-酮和2-甲基-1-异噻唑啉-3-酮的混合物；5-氯-2-甲基-1-异噻唑啉-3-酮和 2-甲基-1-异噻唑啉-3-酮的混合物；(5-氯-2-甲基-4-异噻唑-3-酮)+(2-甲基-4-异噻唑-3-酮)
• 英文名称: Kathon 886
• 英文别名: 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
• CAS: 55965-84-9
• 化学式: C8H9ClN2O2S2
• 分子量: 264.8
• InChiKey: QYYMDNHUJFIDDQ-UHFFFAOYSA-N

物化性质

• 沸点：
  100.1℃ at 101.325kPa
• 密度：
  d20 1.19
• 溶解度：
  氯仿（可溶）、DMSO（少量溶解）、甲醇（少量溶解）、水
• LogP：
  -0.34-0.81 at 10-30℃ and pH5-9
• 表面张力：
  72.6-73mN/m at 1-1.106g/L and 19.5-20℃
• 解离常数：
  2.81-4.2 at 20-25℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.55
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.2
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

制备方法与用途

异噻唑啉酮是目前国际上公认的最有效的防腐、防霉、杀菌剂，广泛应用于循环冷取水、造纸、涂料、日化、纺织、皮革和木材等领域。它具有高效、广谱和环保的优良特性，并且具有良好的配伍性。

优势与特点 异噻唑啉酮具有以下特点：

• 广谱杀菌功能：能有效杀灭藻类、细菌和真菌。
• 有效用量少：约1ppm的有效活性用量即可达到理想的杀菌效果。
• 无毒无污染：稀释使用浓度后，很容易被生物降解为无毒无污染物质。
• 易溶于水：极易混合在各类配方中，pH使用范围广。

生产方法 二硫代二丙酸二甲酯与甲胺进行氨解反应生成N,N′-二甲基二硫代二丙酰胺，然后在乙酸乙酯溶液中通氯气反应。产物经过滤、洗涤、干燥即得。产品中两个活性组分的比例对产品性能有很大影响。

反应信息

• 作为反应物：
  描述：

  水 、 柠檬酸 、 异噻唑啉酮 以 甘油 为溶剂， 反应 0.03h， 以obtained by oxidation of 5,6-dihydroxyindole的产率得到5,6-二羟基吲哚
  参考文献：
  名称：

  Cosmetic composition containing melaninlike pigments in combination with

  摘要：

  本发明涉及一种化妆品组合物，其包含来自天然或合成来源的至少一种类黑色素色素与某些生育酚的组合，以及一种在化妆品中可接受的载体，以及一种保护皮肤、黏膜、头发和化妆品组合物免受自由基的过程。

  公开号：

  US05547658A1
• 作为产物：
  描述：

  5-氯-2-甲基-4-异噻唑啉-3-酮 、 甲基异噻唑啉酮 以 乙二醇 为溶剂， 生成 异噻唑啉酮
  参考文献：
  名称：

  Antimicrobial and antiseptic methods using antimicrobial composition

  摘要：

  提供了一种抗微生物组合物，通过形成均一溶液，降低了异噻唑烷类化合物的皮肤刺激性，并改善了其注射操作性能。该组合物含有异噻唑烷类化合物和一种化合物，其在摩尔比为1：0.1-50时降低前者的皮肤刺激性，并溶解于溶剂中。

  公开号：

  US06159999A1

文献信息

• ANTIMICROBIAL COMPOSITIONS COMPRISING TRIMETHYLENE GLYCOL OLIGOMER AND METHODS OF USING THE COMPOSITIONS
  申请人：Fenyvesi Gyorgyi

  公开号：US20110224307A1

  公开（公告）日：2011-09-15

  Disclosed are antimicrobial compositions, and methods for killing, inhibiting, or preventing the growth of microbes, using trimethylene glycol oligomers or dimers. The trimethylene glycol oligomers and dimers have the formula R(CH 2 CH 2 CH 2 —O—CH 2 CH 2 CH 2 ) n R 1 where R and R 1 are hydroxyl, amine, or ester functionalitiess, and n is 2 or higher. The antimicrobial compositions are useful in personal care and cosmetic compositions

  本发明涉及抗微生物组合物，以及使用三亚甲基二醇低聚物或二聚物杀灭、抑制或防止微生物生长的方法。所述三亚甲基二醇低聚物和二聚物的化学式为R(CH2CH2CH2—O—CH2CH2CH2)nR1，其中R和R1是羟基、胺基或酯基官能团，n为2或更高。所述抗微生物组合物适用于个人护理和化妆品组合物。
• Emulsion polymerization methods involving lightly modified clay and compositions comprising same
  申请人：——

  公开号：US20040220317A1

  公开（公告）日：2004-11-04

  Processes for utilizing various emulsion polymerization procedures for preparing aqueous nanocomposite dispersions are disclosed. The disclosed processes include both in-situ polymerizations in the presence of at least partially exfoliated, lightly modified clays as well as admixtures of polymer dispersions with at least partially exfoliated, lightly modified clay dispersions. The disclosed nanocomposite dispersions are useful for preparing a variety of materials, such as coatings, adhesives, caulks, sealants, plastics additives, and thermoplastic resins. Processes for preparing polymer nanocomposite powders and use of these powders as plastic resin and plastics additives are also disclosed.

  本发明公开了利用各种乳液聚合工艺制备水性纳米复合分散体的方法。所公开的工艺包括在部分剥离、轻度改性的粘土存在下进行原位聚合，以及聚合物分散液与部分剥离、轻度改性的粘土分散液的混合物。所公开的纳米复合分散体可用于制备各种材料，如涂料、粘合剂、填缝剂、密封剂、塑料添加剂和热塑性树脂。本发明还公开了制备聚合物纳米复合粉末的方法以及使用这些粉末作为塑料树脂和塑料添加剂的方法。
• Compositions and process for preserving wood
  申请人：Mooney Chemicals, Inc.

  公开号：US04783221A1

  公开（公告）日：1988-11-08

  Novel compositions of matter and processes for utilizing such compositions in preserving wood are described. More particularly, the novel compositions comprise (A) at least one metal salt of an organic carboxylic acid containing at least about 6 carbon atoms wherein the metal is selected from the group consisting of transition metals, zinc, mercury, antimony and lead, (B) at least one isothiazolone compound represented by the structural formula ##STR1## wherein R.sup.1 is an alkyl, alkenyl or alkynyl group of 1 to about 18 carbon atoms; a cycloalkyl group having a 3 to 6 carbon atom ring and up to about 12 carbon atoms; an aralkyl or aryl group of up to about 10 carbon atoms; R.sup.2 is hydrogen, halogen or a lower alkyl group; and R.sup.3 is hydrogen, halogen or a lower alkyl group, and p0 (C) at least one solvent/diluent. The solvent/diluent may be water or one or more hydrocarbon solvents. The novel compositions of the invention are useful in preserving wood, and when so used, the compositions also may include flame retardants, water repellents, odorants, insecticides, etc.

  本发明描述了新型物质组合物及其在保护木材中的应用过程。更具体地，新型组合物包括（A）至少一种有机羧酸金属盐，该有机羧酸含有至少约6个碳原子，金属选自过渡金属、锌、汞、锑和铅；（B）至少一种异噻唑酮化合物，其结构式为##STR1##其中R.sup.1是1至约18个碳原子的烷基、烯基或炔基；具有3至6个碳原子环和多达约12个碳原子的环状烷基；具有多达约10个碳原子的芳基或芳基烷基；R.sup.2是氢、卤素或较低的烷基；R.sup.3是氢、卤素或较低的烷基，以及（C）至少一种溶剂/稀释剂。溶剂/稀释剂可以是水或一个或多个烃类溶剂。本发明的新型组合物在保护木材方面有用，当这样使用时，组合物也可以包括阻燃剂、防水剂、香料、杀虫剂等。
• Methods for detection of immunosuppressant drugs
  申请人：Siemens Healthcare Diagnostics

  公开号：US07790401B2

  公开（公告）日：2010-09-07

  Methods and reagents are disclosed for enhancing the bioavailability of a hydrophobic drug, and in some embodiments for determining a hydrophobic drug, in a sample suspected of containing a hydrophobic drug. A combination is formed in a medium where the combination comprises the sample, a hemolytic agent where a determination of the hydrophobic drug is conducted, and a bioavailability agent for the hydrophobic drug. The bioavailability agent comprises an ionic detergent comprising a chain of at least 10 carbon atoms or a non-ionic detergent comprising a chain of at least 15 repeating ethylene oxide units or propylene oxide units or a combination of ethylene oxide units and propylene oxide units. The concentration of the bioavailability agent in the medium is sufficient to enhance the bioavailability of the hydrophobic drug. The medium is incubated under conditions for enhancing the bioavailability of the hydrophobic drug, and in a determination of the hydrophobic drug under conditions for hemolyzing cells in the sample. For determination of the hydrophobic drug, reagents for determining the presence and/or amount of the hydrophobic drug in the sample are added to the medium. The reagents comprise at least one antibody for the hydrophobic drug. The medium is examined for the presence of a complex comprising the hydrophobic drug and the antibody for the hydrophobic drug. The presence and/or amount of the complex indicates the presence and/or amount of the hydrophobic drug in the sample.

  本文披露了一种增强疏水药物生物利用度的方法和试剂，并在某些实施例中用于确定疏水药物在疑似含有疏水药物的样品中的存在。在介质中形成一种组合物，其中组合物包括样品、溶血剂（用于对疏水药物进行测定）和疏水药物的生物利用度剂。生物利用度剂包括至少10个碳原子链的离子性洗涤剂或至少15个重复的乙氧基单元或丙氧基单元的非离子性洗涤剂或乙氧基单元和丙氧基单元的组合物。介质中生物利用度剂的浓度足以增强疏水药物的生物利用度。在增强疏水药物的生物利用度条件下孵育介质，并在 hemolyzing 细胞的条件下对疏水药物进行测定。对于疏水药物的测定，向介质中添加用于确定样品中疏水药物存在和/或数量的试剂。试剂包括至少一种疏水药物的抗体。检查介质中是否存在包括疏水药物和疏水药物抗体的复合物。复合物的存在和/或数量表明样品中存在和/或数量的疏水药物。
• Process for preparing 3-isothiazolone compounds
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0490564A1

  公开（公告）日：1992-06-17

  A process for the prepartion of salt-free, and optionally water-free, isothiazolones comprising treating a solution of an acid salt of an isothiazolone with a basic anion exchange resin, perferably a weak base anion exchange resin, and separating the free base isothiazolone solution from the spent resin is disclosed. The resultant salt-free isothiazolones are useful as microbicides in environments where even low concentrations of metal salts are undesirable, for example, latex emulsions and corrosion sensitive aqueous systems.

  本发明公开了一种制备无盐和可选无水异噻唑啉酮的工艺，包括用碱性阴离子交换树脂（最好是弱碱阴离子交换树脂）处理异噻唑啉酮的酸性盐溶液，并从废树脂中分离游离碱异噻唑啉酮溶液。由此制得的无盐异噻唑酮可用作杀微生物剂，适用于即使是低浓度金属盐也不可取的环境，例如乳胶乳液和对腐蚀敏感的水体系。