3-oxo-28-hydroxyfriedelane | 14440-41-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-oxo-28-hydroxyfriedelane
• 英文别名: canophyllol；28-hydroxyfriedelin；28-hydroxyfriedelan-3-one；(4R,4aS,6aS,6aS,6bR,8aS,12aS,14aS,14bS)-8a-(hydroxymethyl)-4,4a,6a,6b,11,11,14a-heptamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1H-picen-3-one
• CAS: 14440-41-6
• 化学式: C₃₀H₅₀O₂
• 分子量: 442.726
• InChiKey: YPWQSKQSNNTXOL-TWWFCBCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-oxo-28-hydroxyfriedelane 在 吡啶 、 chromium(VI) oxide 、 氘氧化钠 、 肼-D4 、 对甲苯磺酸 作用下， 以 丙酮 、 苯 为溶剂， 反应 54.0h， 生成 friedelin-28,28-d₂
  参考文献：
  名称：

  Kikuchi, Tohru; Yokoi, Toshio; Niwa, Mineo, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 7, p. 2014 - 2023

  摘要：

  DOI：
• 作为产物：
  描述：

  海棠果醛 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以0.019 g的产率得到3-oxo-28-hydroxyfriedelane
  参考文献：
  名称：

  Triterpenes and neoflavonoids of Calophyllum lankaensis and Calophyllum thwaitesii

  摘要：

  DOI：

  10.1016/s0031-9422(00)84107-2

文献信息

• [EN] COMPOUNDS FOR REDUCING GLUCOCORTICOIDS, AND METHODS OF TREATMENT THEREOF<br/>[FR] COMPOSÉS PERMETTANT DE RÉDUIRE LES GLUCOCORTICOÏDES, ET PROCÉDÉS DE TRAITEMENT ASSOCIÉS
  申请人：BIONICHE LIFE SCIENCES INC

  公开号：WO2014071506A1

  公开（公告）日：2014-05-15

  A method for reducing glucocorticoids in an animal in need thereof comprising the use of compounds of the formula (I), wherein the definitions for R', R1-R11 and n are as disclosed in the description. The compounds of formula (I) are for the treatment or prevention of a glucocorticoid-related disorder for maintaining bone density, maintaining and improving the immune system, treating Cushing' s syndrome, treating obesity, improving reproduction efficiency, treating metabolic disorder, treating hypertension, treating hyperglycemia, treating insulin resistance, treating type 2 diabetes, and/or aiding in cancer and immune therapies

  一种用于减少需要动物体内糖皮质激素的方法，包括使用式(I)的化合物，其中R'、R1-R11和n的定义如描述中所披露。式(I)的化合物用于治疗或预防与糖皮质激素相关的疾病，以维持骨密度、维护和改善免疫系统、治疗库欣综合征、治疗肥胖、提高生殖效率、治疗代谢紊乱、治疗高血压、治疗高血糖、治疗胰岛素抵抗、治疗2型糖尿病，和/或在癌症和免疫疗法中发挥作用。
• Antitumour triterpenes of Maytenus diversifolia
  作者：Hiroshi Nozaki、Hideyo Suzuki、Teruhisa Hirayama、Ryoji Kasai、Rong-Yang Wu、Kuo-Hsiung Lee

  DOI：10.1016/s0031-9422(00)85505-3

  日期：1986.1

  Abstract The known compounds maytansine and sitosterol-β- D -glucoside as well as the new triterpenes maytenfoliol and maytenfolic acid were isolated as antileukemic agents from Maytenus diversifolia . Other triterpenes isolated included the new maytensifolin-A and -B as well as the known friedelin, canophyllal, β-amyrin, canophyllol, pachysonol, 29-hydroxyfriedelan-3-one and 30-hydroxyfriedelan-3-one

  摘要 从美登木素中分离出已知化合物美登素和谷甾醇-β-D-葡萄糖苷以及新的三萜类美登叶醇和美登叶酸作为抗白血病药物。分离出的其他三萜包括新的美藤叶素-A 和-B 以及已知的油香素、树油醛、β-香树脂醇、树油酚、厚皮素、29-羟基弗里德兰-3-one 和 30-羟基弗里德兰-3-one。
• Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof
  申请人：BIONICHE LIFE SCIENCES INC.

  公开号：US20150272922A1

  公开（公告）日：2015-10-01

  A method for reducing glucocorticoids in an animal in need thereof comprising the use of compounds of the formula (I), wherein the definitions for R′, R 1 -R 11 and n are as disclosed in the description. The compounds of formula (I) are for the treatment or prevention of a glucocorticoid-related disorder for maintaining bone density, maintaining and improving the immune system, treating Cushing's syndrome, treating obesity, improving reproduction efficiency, treating metabolic disorder, treating hypertension, treating hyperglycemia, treating insulin resistance, treating type 2 diabetes, and/or aiding in cancer and immune therapies

  一种用于减少需要此类治疗的动物中的糖皮质激素的方法，包括使用式(I)中的化合物，其中R′、R1-R11和n的定义如说明书所述。式(I)中的化合物用于治疗或预防与糖皮质激素相关的疾病，以维持骨密度，维持和改善免疫系统，治疗库欣综合征，治疗肥胖症，提高生殖效率，治疗代谢紊乱，治疗高血压，治疗高血糖，治疗胰岛素抵抗，治疗2型糖尿病，并且对癌症和免疫治疗有帮助。
• HERBAL POLYPHARMACEUTICAL FOR PREVENTING AND TREATING ATHEROSCLEROSIS
  申请人：Castañeda Miranda, José Arturo

  公开号：EP2684567A1

  公开（公告）日：2014-01-15

  Herbal MDR for the prevention and treatment of atherosclerosis which includes a summary of the genus Gentiana and a summary of the genus Hippocratea, in particular, gentiana lutea and hippocratea excelsa. Comes as a solid, preferably capsules. Herbal composition is obtained by selecting Rhizome and root of Gentiana luteablending by centrifugation, and separating the supernatant which mingles with the alcoholic extract of Hippocratea excelsa. Applies in the prevention and treatment of atherosclerosis, as well as in atherosclerotic Occlusive disease complications such as blockage of coronary arteries and arteries that supply the heart.

  用于预防和治疗动脉粥样硬化的草药 MDR，包括龙胆草属和海马草属（尤其是龙胆草和海马草）的摘要。以固体形式提供，最好是胶囊。草药成分是通过离心选取 Gentiana luteablending 的根茎和根，分离上清液与 Hippocratea excelsa 的酒精提取物混合后得到的。适用于预防和治疗动脉粥样硬化，以及动脉粥样硬化性闭塞症并发症，如冠状动脉和供应心脏的动脉堵塞。
• Triterpenes of calophyllum inophyllum linn
  作者：T.R. Govindachari、N. Viswanathan、B.R. Pai、U.Ramadas Rao、M. Srinivasan

  DOI：10.1016/s0040-4020(01)82592-8

  日期：1967.1