3-Amino-4-(5-chloro-2-methoxyphenyl)quinolin-2(1H)-one | 221112-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Amino-4-(5-chloro-2-methoxyphenyl)quinolin-2(1H)-one
• 英文别名: 3-amino-4-(5-chloro-2-methoxyphenyl)-1H-quinolin-2-one
• CAS: 221112-51-2
• 化学式: C₁₆H₁₃ClN₂O₂
• 分子量: 300.744
• InChiKey: INRSKUJUENBFPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Amino-4-(5-chloro-2-methoxyphenyl)quinolin-2(1H)-one 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 3-Amino-4-(5-chloro-2-hydroxyphenyl)quinolin-2(1H)-one
  参考文献：
  名称：

  The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

  摘要：

  A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00240-8
• 作为产物：
  描述：

  N-Boc-苯胺 在 吡啶 、 盐酸 、 叔丁基锂 、 一水合肼 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 3-Amino-4-(5-chloro-2-methoxyphenyl)quinolin-2(1H)-one
  参考文献：
  名称：

  The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

  摘要：

  A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00240-8

文献信息

• US5972961A
  申请人：——

  公开号：US5972961A

  公开（公告）日：1999-10-26
• The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection
  作者：Piyasena Hewawasam、Wenhong Fan、Jay Knipe、Sandra L Moon、Christopher G Boissard、Valentin K Gribkoff、John E Starrett

  DOI：10.1016/s0960-894x(02)00240-8

  日期：2002.7

  A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke. (C) 2002 Elsevier Science Ltd. All rights reserved.