(2Z,7Z)-(4S,5S,6S,9S)-5,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-[(2S,3S,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-phenylsulfanyl-tetrahydro-pyran-2-yl]-2,4,6-trimethyl-deca-2,7-dien-1-ol | 184488-84-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2Z,7Z)-(4S,5S,6S,9S)-5,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-[(2S,3S,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-phenylsulfanyl-tetrahydro-pyran-2-yl]-2,4,6-trimethyl-deca-2,7-dien-1-ol
• CAS: 184488-84-4
• 化学式: C₄₄H₈₂O₅SSi₃
• 分子量: 807.455
• InChiKey: BYSPATBFQBDBIM-BYZVUCQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.1
• 重原子数：
  53.0
• 可旋转键数：
  16.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  57.15
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (2Z,7Z)-(4S,5S,6S,9S)-5,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-[(2S,3S,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-phenylsulfanyl-tetrahydro-pyran-2-yl]-2,4,6-trimethyl-deca-2,7-dien-1-ol 在 三乙胺 、 lithium bromide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 4.25h， 生成
  参考文献：
  名称：

  Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization

  摘要：

  Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents to investigate discodermolide's recently discovered ability to bind and stabilize microtubules in cells, Retrosynthetically, the polypropionate is divided into three fragments of approximately equal complexity. This modular strategy provides convergency in the synthesis and facilitates the preparation of discodermolide-based reagents.

  DOI：

  10.1021/ja961374o
• 作为产物：
  描述：

  2-[(2S,3S,4S,5R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-phenylsulfanyl-tetrahydro-pyran-2-yl]-N-methoxy-N-methyl-acetamide 在 palladium on activated charcoal 2,6-二甲基吡啶 、 chromium dichloride 、 lithium aluminium tetrahydride 、 氢气 、 二异丁基氢化铝 、 nickel dichloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 24.59h， 生成 (2Z,7Z)-(4S,5S,6S,9S)-5,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-[(2S,3S,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-phenylsulfanyl-tetrahydro-pyran-2-yl]-2,4,6-trimethyl-deca-2,7-dien-1-ol
  参考文献：
  名称：

  Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization

  摘要：

  Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents to investigate discodermolide's recently discovered ability to bind and stabilize microtubules in cells, Retrosynthetically, the polypropionate is divided into three fragments of approximately equal complexity. This modular strategy provides convergency in the synthesis and facilitates the preparation of discodermolide-based reagents.

  DOI：

  10.1021/ja961374o