Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula:
wherein R₁ or R₃ is a moiety of the formula:
wherein R₆ is selected from either hydrogen or acetyl; R₇ is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH₂)n, where n is an integer from 1 to 5 and R₁ and R₂, R₂ and R₃, R₃ and R₄ or R₄ and R₅ taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.
具有含氮环系统的新型药物化合物和组合物,可以用以下结构式表示:
其中R₁或R₃是以下式的基团:
其中R₆从氢或乙酰中选择;R₇从2、3或4-
吡啶基或1-
咪唑基中选择,Q为-(CH₂)n,其中n是从1到5的整数,且R₁和R₂、R₂和R₃、R₃和R₄或R₄和R₅一起可能是-CH=CH-CH=CH-。这些化合物和组合物可用作血栓素合酶的
抑制剂,并用于治疗哺乳动物的高血压和心律失常。