[2-(1,4-benzoquinonyl)ethyl]-1,4-benzoquinone | 20452-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [2-(1,4-benzoquinonyl)ethyl]-1,4-benzoquinone
• 英文别名: 2-[2-(3,6-Dioxocyclohexa-1,4-dien-1-yl)ethyl]cyclohexa-2,5-diene-1,4-dione
• CAS: 20452-50-0
• 化学式: C₁₄H₁₀O₄
• 分子量: 242.231
• InChiKey: XWYOMGXZBJEFQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 [2-(1,4-benzoquinonyl)ethyl]-1,4-benzoquinone 以14%的产率得到Acetic acid 4-acetoxy-2-(5-acetoxy-2,3-dihydro-benzofuran-2-yl)-phenyl ester
  参考文献：
  名称：

  Synthesis and electrochemical reduction of [2-(1,4-benzoquinonyl)ethyl]-1,4-benzoquinone

  摘要：

  DOI：

  10.1021/jo00166a049
• 作为产物：
  描述：

  对二甲氧基苯甲醇 在 盐酸 、 sodium chlorate 、 硫酸 、 氢溴酸 、 sodium 、 vanadia 、 溶剂黄146 作用下， 以 乙醚 为溶剂， 反应 48.33h， 生成 [2-(1,4-benzoquinonyl)ethyl]-1,4-benzoquinone
  参考文献：
  名称：

  Synthesis and electrochemical reduction of [2-(1,4-benzoquinonyl)ethyl]-1,4-benzoquinone

  摘要：

  DOI：

  10.1021/jo00166a049

文献信息

• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• Small molecules for the modulation of MCL-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10000511B2

  公开（公告）日：2018-06-19

  This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

  本发明涉及以高亲和力和选择性与存活蛋白 MCL-1 选择性结合的化合物、含有此类化合物的药物组合物，以及使用这些化合物或组合物调节 MCL-1 活性和治疗过度增殖性疾病、血管生成疾病、细胞周期调节疾病、自噬调节疾病、炎症性疾病和/或感染性疾病和/或增强细胞移植和/或伤口修复，可作为单独制剂或与其他活性成分组合使用。
• Chemical entities that kill senescent cells for use in treating age-related disease
  申请人：Unity Biotechnology, Inc.

  公开号：US10195213B2

  公开（公告）日：2019-02-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.

  本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。
• Huenig, Siegfried; Sinzger, Klaus; Kemmer, Martina, European Journal of Organic Chemistry, 1998, # 9, p. 1977 - 1988
  作者：Huenig, Siegfried、Sinzger, Klaus、Kemmer, Martina、Langohr, Uwe、Rieder, Herald、et al.

  DOI：——

  日期：——
• MANDELL, L.;COOPER, S. M.;RUBIN, B.;CAMPANA, C. F.;DAY, R. A. ,, JR, J. ORG. CHEM., 1983, 48, N 18, 3132-3134
  作者：MANDELL, L.、COOPER, S. M.、RUBIN, B.、CAMPANA, C. F.、DAY, R. A. ,, JR

  DOI：——

  日期：——