kaempferol 7-O-rhamnoside | 5041-97-4

• 物质功能分类: 天然产物 - 黄酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: kaempferol 7-O-rhamnoside
• 英文别名: kaempferol-7-O-rhamnoside；apigenin-7-O-rhamnoside；kaempferol 7-rhamnoside；Kaempferol-7-rhamnosid；3,5-dihydroxy-2-(4-hydroxyphenyl)-7-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
• CAS: 5041-97-4；20196-89-8
• 化学式: C₂₁H₂₀O₁₀
• 分子量: 432.384
• InChiKey: HQNOUCSPWAGQND-UIXBWGQISA-N

物化性质

• 熔点：
  231-234℃
• 沸点：
  753.2±60.0 °C(Predicted)
• 密度：
  1.665±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  10

制备方法与用途

生物活性

Kaempferol-7-O-rhamnoside 是从Chimonanthus nitens Oliv叶子中分离出的一种有效α-葡萄糖苷酶活性抑制剂，有潜力用于糖尿病治疗。

靶点

α-葡萄糖苷酶活性

反应信息

• 作为产物：
  描述：

  kaempferol 3-O-glucoside 7-O-rhamnoside 在 β-glucosidase 作用下， 反应 3.0h， 生成 kaempferol 7-O-rhamnoside 、 葡萄糖
  参考文献：
  名称：

  Identification and Quantification of Phenolic Compounds from the Forage Legume Sainfoin (Onobrychis viciifolia)

  摘要：

  Phenolic compounds of sainfoin (Onobrychis viciifolia) variety Cotswold Common are assumed to contribute to its nutritive value and bioactive properties. A purified acetone/water extract was separated by Sephadex LH-20 gel chromatography. Sixty-three phenolic and other aromatic compounds were identified by means of chemical, chromatographic, and spectroscopic methods. Reverse phase HPLC with diode array and chemical reaction detection was used to investigate the phenolic composition of different plant organs. All plant parts showed specific phenolic profiles. Moreover, there were considerable variations in the phenolic content among individual plants of the same variety. The three most abundant phenolic compounds were found to be arbutin [predominant in petiols, 17.7 mg/g of dry weight (DW)], rutin (predominant in leaves, 19.9 mg/g of DW), and catechin (predominant flavanol in petiols, 3.5 mg/g of DW). The present study reveals that the phenolic profile of sainfoin is even more complex than hitherto assumed.

  DOI：

  10.1021/jf900625r

文献信息

• Use of extracts of the cassia alata plant
  申请人：——

  公开号：US20030180231A1

  公开（公告）日：2003-09-25

  The invention relates to the use of extracts of the Cassia alata plant in cosmetic and/or dermatological skin care products.

  本发明涉及使用决明子的提取物 决明子 植物提取物在化妆品和/或皮肤护理产品中的用途。
• COMPOSITION AND METHOD FOR SKIN REPAIR
  申请人：Access Business Group International LLC

  公开号：EP2473180A2

  公开（公告）日：2012-07-11
• Composition and Method for Skin Repair
  申请人：Brumbaugh Ernest H.

  公开号：US20110052741A1

  公开（公告）日：2011-03-03

  A composition and a method of using the composition is described that is effective to protect or repair oxidative damage to DNA in mammalian skin by up regulating each of SIRT1, Gadd45b, and SOD2. The composition includes at least two of a candle bush extract, noni leaf extract, and melon extract with each present in an amount such that the composition is effective to up regulate each of SIRT1, Gadd45b, and SOD2.
• US8389026B2
  申请人：——

  公开号：US8389026B2

  公开（公告）日：2013-03-05
• US8535731B2
  申请人：——

  公开号：US8535731B2

  公开（公告）日：2013-09-17