The invention provides compounds of Formula (II) which comprise two terminal 2-aminoquinoline moieties. They are novel and potent inhibitors of the p47phox-p22phox protein-protein interaction that can inhibit the assembly and thus activation of the multisubunit and superoxide-generating NADPH oxidase 2 complex. The compounds are therapeutically relevant as they can reduce cell damage in diseases where NADPH oxidase 2 is a major contributor to generation of reactive oxygen species (ROS) and oxidative stress.
该发明提供了公式(II)的化合物,其中包括两个末端的
2-氨基喹啉基团。它们是新颖且有效的 p47phox-p22phox 蛋白质相互作用
抑制剂,可以抑制多亚基和产生超氧化物的
NADPH 氧化酶 2 复合物的组装和激活。这些化合物在治疗上具有重要意义,因为它们可以减少
NADPH 氧化酶 2 在产生活性氧物种(ROS)和氧化应激中起主要作用的疾病中的细胞损伤。