3-羟基-1,7,7-三甲基双环[2.2.1]庚烷-2-酮 | 10373-81-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3-羟基-1,7,7-三甲基双环[2.2.1]庚烷-2-酮
• 英文名称: 3-hydroxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one
• 英文别名: α-hydroxycamphor；3-hydroxy-bornan-2-one；3-Hydroxy-bornan-2-on；Hydroxy-3-endo-bornanone-2；3-hydroxy-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
• CAS: 10373-81-6
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: AXMKZEOEXSKFJI-UHFFFAOYSA-N

物化性质

• 熔点：
  205.5°C
• 沸点：
  237.18°C (rough estimate)
• 密度：
  0.9607 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-羟基-1,7,7-三甲基双环[2.2.1]庚烷-2-酮 生成 (1R)-(-)-樟脑醌
  参考文献：
  名称：

  Ishidate, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1928, vol. 48, p. 77

  摘要：

  DOI：
• 作为产物：
  描述：

  D-溴樟脑 在 air 、 三乙胺 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 72.0h， 以86%的产率得到3-羟基-1,7,7-三甲基双环[2.2.1]庚烷-2-酮
  参考文献：
  名称：

  Photo-irradiation of α-halo carbonyl compounds: a novel synthesis of α-hydroxy- and α,α′-dihydroxyketones

  摘要：

  The reaction of g.-halo ketones (alpha-iodocycloalkanones, alpha-bromocycloalkanones, alpha-iodo-beta-alkoxy esters, and alpha-iodoacyclic-ketones) with irradiation under a high-pressure mercury lamp gave the corresponding alpha-hydroxyketones in good yields. For alpha-bromoketones, it was found that alpha-hydroxylation does not occur. However, alpha-bromoketones were convened into a-hydroxyketones in the presence of KI. In the case of alpha,alpha(1)-diiodo ketones, alpha,alpha(1)-dihydroxyketones, which up to now have scarcely been reported, were obtained. This reaction affords a new, clean and convenient synthetic method for alpha-hydroxy- and alpha,alpha(1)-dihydroxyketones. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.01.010

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Regio- and Diastereoselective Reduction of Nonenolizable α-Diketones to Acyloins Mediated by Indium Metal
  作者：Faiz Ahmed Khan、Jyotirmayee Dash、Nilam Sahu、Sharad Gupta

  DOI：10.1021/ol025593s

  日期：2002.3.1

  [reaction: see text] Alpha-diketones are efficiently reduced with indium metal in methanol-water in the presence of NH(4)Cl, LiCl, or NaCl to give regio- and diastereoselectively the corresponding acyloins in good to excellent yield. The cleavage of the acyloins under Pb(OAc)(4)/MeOH-PhH condition provides a convenient and regioselective access to highly functionalized cyclopentane carboxaldehydes

  [反应：见正文]在NH-（4）Cl，LiCl或NaCl存在下，用甲醇-水中的铟金属可有效还原α-二酮，从而以良好或优异的收率选择性和选择性地产生相应的酰基。在Pb（OAc）（4）/ MeOH-PhH条件下酰化酶的裂解提供了对高度官能化的环戊烷甲醛的便捷和区域选择性的途径，而后者是有机合成中的潜在基础。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Particle binders
  申请人：WEYERHAEUSER COMPANY

  公开号：EP1219744A1

  公开（公告）日：2002-07-03

  This invention concerns polymeric and non-polymeric binders for fibers and the use of such binders in binding particles to fibers.

  本发明涉及用于纤维的聚合物和非聚合物粘合剂，以及使用此类粘合剂将颗粒与纤维粘合。