3,6-硫代蒽二胺 | 10215-25-5

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 中文名称: 3,6-硫代蒽二胺
• 中文别名: 3,6-硫氧杂蒽二胺-10,10-二氧化物
• 英文名称: 3,6-diamino-thioxanthene-10,10-dioxide
• 英文别名: 3,6-Diamino-thioxanthen-10,10-dioxid；9H-thioxanthene-3,6-diamine 10,10-dioxide；9H-Thioxanthene-3,6-diamine, 10,10-dioxide；10,10-dioxo-9H-thioxanthene-3,6-diamine
• CAS: 10215-25-5
• 化学式: C₁₃H₁₂N₂O₂S
• mdl: MFCD00041841
• 分子量: 260.316
• InChiKey: UPVRZVIJGVFROW-UHFFFAOYSA-N

物化性质

• 熔点：
  213-215 °C
• 沸点：
  570.3±50.0 °C(Predicted)
• 密度：
  1.2693 (rough estimate)
• 溶解度：
  DMSO（轻微）、乙酸乙酯（轻微、加热）
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2934999090
• 储存条件：
  应存于阴凉干燥环境中。

SDS

Name:	3 6-Thioxanthenediamine-10 10-Dioxide Material Safety Data Sheet
Synonym:	None known
CAS:	10215-25-5

Section 1 - Chemical Product MSDS Name:3 6-Thioxanthenediamine-10 10-Dioxide Material Safety Data Sheet
Synonym:None known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10215-25-5	9h-thioxanthene-3,6-diamine, 10,10-dio	ca 100	233-527-1

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 10215-25-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 213.00 - 215.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C13H12N2O2S
Molecular Weight: 260.32

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 10215-25-5: XO0668000 LD50/LC50:
Not available.
Carcinogenicity:
9h-thioxanthene-3,6-diamine, 10,10-dioxide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 10215-25-5: No information available.
Canada
CAS# 10215-25-5 is listed on Canada's NDSL List.
CAS# 10215-25-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 10215-25-5 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3,6-硫代蒽二胺 在 正丁基锂 、 四氯苯醌 、 potassium carbonate 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  荧光砜-吡喃宁和砜-罗莎明染料的合成，稳定性和光谱行为

  摘要：

  提出了带有光学可调伯氨基（起荧光中心）作用的砜-吡喃宁和砜-罗莎明染料的首次合成。基于x吨的荧光团的砜类似物最近已被强调为一类新的近红外（NIR）荧光染料（Liu等人，ACS Appl Mater Interfaces 2016; 8（35）：22953-62），以及荧光染料的可用性衍生物对于快速构建化学选择性生物成像的“开启”反应性探针至关重要。然而，已发现这些荧光苯胺在水性生理条件下不稳定，这是由于它们的内消旋体具有明显的亲电子性。-位，因此其易于受到水分子或羟基阴离子的亲核攻击。进一步的研究已经帮助我们确定了砜-罗莎明2完全稳定的酸性pH范围，并且可以对光物理性质进行完整的评估。然后，通过对青霉素G酰基转移酶（PGA）敏感的荧光探针的制备和体外酶促活化，证明了其促荧光特性和实用性。

  DOI：

  10.1016/j.dyepig.2018.06.026
• 作为产物：
  描述：

  4,4'-二氨基二苯甲烷 在 发烟硫酸 作用下， 反应 17.0h， 以83%的产率得到3,6-硫代蒽二胺
  参考文献：
  名称：

  荧光砜-吡喃宁和砜-罗莎明染料的合成，稳定性和光谱行为

  摘要：

  提出了带有光学可调伯氨基（起荧光中心）作用的砜-吡喃宁和砜-罗莎明染料的首次合成。基于x吨的荧光团的砜类似物最近已被强调为一类新的近红外（NIR）荧光染料（Liu等人，ACS Appl Mater Interfaces 2016; 8（35）：22953-62），以及荧光染料的可用性衍生物对于快速构建化学选择性生物成像的“开启”反应性探针至关重要。然而，已发现这些荧光苯胺在水性生理条件下不稳定，这是由于它们的内消旋体具有明显的亲电子性。-位，因此其易于受到水分子或羟基阴离子的亲核攻击。进一步的研究已经帮助我们确定了砜-罗莎明2完全稳定的酸性pH范围，并且可以对光物理性质进行完整的评估。然后，通过对青霉素G酰基转移酶（PGA）敏感的荧光探针的制备和体外酶促活化，证明了其促荧光特性和实用性。

  DOI：

  10.1016/j.dyepig.2018.06.026

文献信息

• [EN] PHOTOALIGNING MATERIALS<br/>[FR] MATÉRIAUX DE PHOTOALIGNEMENT
  申请人：ROLIC AG

  公开号：WO2013050121A1

  公开（公告）日：2013-04-11

  The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, comprising a main chain and a side chain, wherein the side chain and/or main chain comprises a polar group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).

  本发明涉及用于液晶的光调向的聚合物、同聚物或寡聚物，特别用于液晶的平面取向，包括主链和侧链，其中侧链和/或主链包含极性基团，以及其组合物，以及其在光学和电光设备中的应用，特别是液晶设备（LCD）。
• PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP
  申请人：Eckert Jean-Francois

  公开号：US20100048849A1

  公开（公告）日：2010-02-25

  A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.

  提出了一种化学式为（I）的二胺化合物，以及基于该化合物的聚合物，共聚物，聚酰胺酸，聚酰胺酸酯或聚酰亚胺。
• Photocrosslinkable Materials
  申请人：Bachels Thomas

  公开号：US20080293888A1

  公开（公告）日：2008-11-27

  A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.

  提出了一种化学式为(I)的二胺化合物，以及基于该化合物的聚合物、共聚物、聚酰胺酸、聚酰胺酸酯或聚酰亚胺。
• Anti-Malarial Compounds
  申请人：Scott Richard W.

  公开号：US20100081665A1

  公开（公告）日：2010-04-01

  The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.

  本发明提供了三环化合物、芳香酰胺化合物和其他化合物以及包含它们的组合物，用于治疗疟疾，并且提供了通过将这些化合物用于动物的方法来治疗疟疾。
• PHOTOCROSSLINKABLE MATERIALS
  申请人：BACHELS Thomas

  公开号：US20120076952A1

  公开（公告）日：2012-03-29

  A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.

  提议一种化学式为（I）的二胺化合物，以及基于该化合物的聚合物、共聚物、聚酰胺酸、聚酰胺酸酯或聚酰亚胺。