1-甲基-1H-吲哚-5-羧酸甲酯 | 128742-76-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1-甲基-1H-吲哚-5-羧酸甲酯
• 中文别名: 1-甲基吲哚-5-羧酸甲酯
• 英文名称: methyl 1-methyl-1H-indole-5-carboxylate
• 英文别名: methyl 1-methylindole-5-carboxylate；methyl N-methylindole-5-carboxylate；1-methyl-1H-indole-5-carboxylic acid methyl ester；1-methyl-indole-5-carboxylic acid methyl ester
• CAS: 128742-76-7
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: VJJMGOYLSMSMCD-UHFFFAOYSA-N

物化性质

• 沸点：
  320.2±15.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302
• 储存条件：
  室温

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Methyl 1-methylindole-5-carboxylate
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Methyl 1-methylindole-5-carboxylate
CAS number: 128742-76-7

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C11H11NO2
Molecular weight: 189.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-甲基-1H-吲哚-5-羧酸甲酯 在 水 、 碘 、 chloramine-B 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以71%的产率得到methyl 1-methyl-2,3-dioxoindoline-5-carboxylate
  参考文献：
  名称：

  使用氯胺-B 碘催化氧化 N-取代的吲哚：一种简便实用的靛红方法

  摘要：

  探索了一种在温和反应条件下使用氯胺-B 碘催化氧化N-取代吲哚的有效方法。发现该反应对多种官能团具有耐受性，并以中等至极好的产率提供相应的靛红。此外，还实现了该方法在3-羟基吲哚和N-甲基靛红肟的一锅法合成中的应用。

  DOI：

  10.1002/ejoc.201600061
• 作为产物：
  描述：

  methyl 1-methylindoline-5-carboxylate 在 N-羟基邻苯二甲酰亚胺 、 copper(II) acetate monohydrate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以74%的产率得到1-甲基-1H-吲哚-5-羧酸甲酯
  参考文献：
  名称：

  N-羟基邻苯二甲酰亚胺催化N-杂环的好氧脱氢素

  摘要：

  报道了N杂环有氧脱氢的催化方法。在大多数情况下，使用催化的N-羟基邻苯二甲酰亚胺（NHPI）作为唯一的添加剂，可以从二氢吲哚中高效地获得吲哚。进一步的研究表明，NHPI和铜的催化体系得到改进，可用于制备其他杂芳族化合物，例如喹啉。

  DOI：

  10.1002/adsc.202000767
• 作为试剂：
  描述：

  吲哚-5-羧酸 、 sodium;hydride 、 碘甲烷 、 1-甲基-1H-吲哚-5-羧酸甲酯 、 sodium hydroxide 在 氮气 、 toluene-ethyl acetate 、 magnesium sulfate 、 1-甲基-1H-吲哚-5-羧酸甲酯 、 乙酸乙酯 、 盐酸 作用下， 以 N,N-二甲基甲酰胺 、 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 192.67h， 以to give 1-methyl-1H-indol-5-carboxylic acid (1.08 g, 96%)的产率得到1-甲基-1H-吲哚-5-甲酸
  参考文献：
  名称：

  Pyrrole derivatives

  摘要：

  以下为公式所代表的吡咯衍生物：其中环Z为可选取代的吡咯环等；W2为—CO—，—SO2—，可选取代的C1-C4烷基等；Ar2为可选取代的芳基等；W1和Ar1表示如下（1）和（2）：（1）W1为可选取代的C1-C4烷基等；Ar1为具有1至4个氮原子作为环构成原子的可选取代的双环杂芳基：（2）W1为可选取代的C2-C5烷基、可选取代的C2-C5烯基等；Ar1为芳基或单环杂芳基，其在与W1的结合位置相对的邻位或间位上被羧基、烷氧基羰基等取代，或其药学上可接受的盐。这些化合物可用作药物，例如纤维化器官或组织的抑制剂。

  公开号：

  US06759429B2

文献信息

• Chiral Pincer Carbodicarbene Ligands for Enantioselective Rhodium-Catalyzed Hydroarylation of Terminal and Internal 1,3-Dienes with Indoles
  作者：Justin S. Marcum、Courtney C. Roberts、Rajith S. Manan、Tia N. Cervarich、Simon J. Meek

  DOI：10.1021/jacs.7b08575

  日期：2017.11.8

  Catalytic enantioselective addition of N-heteroarenes to terminal and internal 1,3-dienes is reported. Reactions are promoted by 5 mol % of Rh catalyst supported by a new chiral pincer carbodicarbene ligand that delivers allylic substituted arenes in up to 95% yield and up to 98:2 er. Mechanistic and X-ray evidence is presented that supports that the reaction proceeds via a Rh(III)-η3-allyl.

  据报道N-杂芳烃向末端和内部1，3-二烯的催化对映选择性加成。5 mol％的Rh催化剂促进了反应，该催化剂由新型手性钳碳二碳烯配体支撑，该配体可提供高达95％的收率和高达98：2 er的烯丙基取代的芳烃。机械和透视证据呈现支持经由铑（III）-η反应进行3 -烯丙基。
• FIBROSIS INHIBITOR
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：EP1479384A1

  公开（公告）日：2004-11-24

  Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is -CO-, -SO2-, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2): (1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.

  药物作为器官或组织的纤维化抑制剂而有用，包括具有以下式（I）的化合物： 其中环Z是可选择取代的吡咯环等；W2是-CO-，-SO2-，可选择取代的C1-C4烷基等；Ar2是可选择取代的芳基等；W1和Ar1表示如下（1）和（2）： （1）W1是可选择取代的C1-C4烷基等；Ar1是可选择取代的具有1至4个氮原子作为环形成原子的双环杂芳基： （2）W1是可选择取代的C2-C5烷基，可选择取代的C2-C5烯基等；以及 Ar1是芳基或单环杂芳基，其在相对于W1的结合位置的邻位或间位处被羧基，烷氧羰基等取代， 或其药学上可接受的盐。
• NEW AMINOTHIAZOLES AS FBPASE INHIBITORS FOR DIABETES
  申请人：Hebeisen Paul

  公开号：US20090143448A1

  公开（公告）日：2009-06-04

  Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 3 have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.

  式(I)的化合物以及其药用可接受的盐和酯，其中R1至R3具有权利要求1中给定的含义，并可用于制成药物组合物。
• Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system
  作者：Wei Tian、Bowen Li、Duanshuai Tian、Wenjun Tang

  DOI：10.1016/j.cclet.2021.06.091

  日期：2022.1

  A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4Å molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through

  通过使用 P,P=O 配体开发了钯催化的吲哚与 α-溴酯的 2-烷基化反应。该方法具有优异的区域选择性、温和的反应条件和良好的官能团相容性。P,P=O 配体以及 4Å 分子筛的使用对于转化的成功至关重要。机理研究表明反应通过自由基途径进行。
• [EN] FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS<br/>[FR] INDOLES FONCTIONNALISÉS ET SUBSTITUÉS UTILISÉS EN TANT QU'AGENTS ANTI-CANCÉREUX
  申请人：NOVOGEN LTD

  公开号：WO2015074123A1

  公开（公告）日：2015-05-28

  The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.

  本发明涉及抗肌球蛋白化合物，其制备方法，以及利用本发明的化合物治疗或预防增殖性疾病，优选癌症的方法。