乙基三苯基氯化膦 | 896-33-3

• 物质功能分类: 有机原料
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 乙基三苯基氯化膦
• 中文别名: 乙基三苯基氯化磷,ETPPCI；三苯基乙基氯化；乙基三苯基氯化粼；三苯基乙基氯化膦；氯化化乙基三苯基瞵；乙基三苯基氯化；乙基三苯基氯化磷；乙基三苯基氯化鏻；三苯基乙基氯化鏻
• 英文名称: ethyltriphenylphosphonium chloride
• 英文别名: triphenylethylphosphonium chloride；Ethyl(triphenyl)phosphonium chloride；ethyl(triphenyl)phosphanium;chloride
• CAS: 896-33-3
• 化学式: C₂₀H₂₀P*Cl
• 分子量: 326.806
• InChiKey: NJXBVBPTDHBAID-UHFFFAOYSA-M

物化性质

• 熔点：
  240-244 °C
• 溶解度：
  溶于甲醇
• 稳定性/保质期：
  常温常压下稳定，避免与水分接触以防氧化。

计算性质

• 辛醇/水分配系数(LogP)：
  1.0
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• TSCA：
  Yes
• 危险等级：
  9
• 危险品标志：
  Xn
• 危险类别码：
  R21/22
• 危险品运输编号：
  UN3077
• 海关编码：
  2931900090
• 包装等级：
  III
• 危险类别：
  9
• 安全说明：
  S24,S36/37
• 储存条件：
  请将容器密封保存，并储存在阴凉、干燥的地方。

SDS

Name:	Ethyl-Triphenylphosphoniumchloride 98% Material Safety Data Sheet
Synonym:	None known
CAS:	896-33-3

Section 1 - Chemical Product MSDS Name:Ethyl-Triphenylphosphoniumchloride 98% Material Safety Data Sheet
Synonym:None known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
896-33-3	Ethyl-Triphenylphosphonium Chloride	98	unlisted

Hazard Symbols: XN
Risk Phrases: 21/22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful in contact with skin and if swallowed.Light sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 896-33-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 242 deg C
Autoignition Temperature: Not applicable.
Flash Point: 240 deg C ( 464.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 240 deg C
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: C20H20ClP
Molecular Weight: 326.79

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, oxides of phosphorus, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 896-33-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Ethyl-Triphenylphosphonium Chloride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 21/22 Harmful in contact with skin and if
swallowed.
Safety Phrases:
S 24 Avoid contact with skin.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 896-33-3: No information available.
Canada
CAS# 896-33-3 is listed on Canada's NDSL List.
CAS# 896-33-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 896-33-3 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质：白色或微黄色结晶。

用途：主要用于药物中间体和医药中间体。

反应信息

• 作为反应物：
  描述：

  乙基三苯基氯化膦 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 亚乙基(三苯基)-lambda~5~-磷烷
  参考文献：
  名称：

  Endrich, K.; Alburquerque, P.; Korswagen, R. P., Zeitschrift fur Naturforschung, B: Chemical Sciences, 1988, vol. 43, # 10, p. 1293 - 1306

  摘要：

  DOI：
• 作为产物：
  描述：

  三苯基氧化膦 在 草酰氯 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.92h， 生成 乙基三苯基氯化膦
  参考文献：
  名称：

  长期寻求从氧化膦合成季phospho盐的方法：逆反应法†

  摘要：

  季phospho盐（QPS）是一类重要的有机磷化合物，以前只能通过涉及亲核性磷的途径获得。我们报告了利用膦氧化物作为亲电子伴侣和格氏试剂作为亲核试剂实现QPS的相反方法的实现。通过衍生的卤化salts盐的关键中间体来实现该过程。该路线不受动力学慢和许多母体膦的有限供应的困扰，并且以优异的产率制备了多种QPS。

  DOI：

  10.1039/c8cc02173b

文献信息

• PHOSPHAPHENANTHRENE-BASED COMPOUND AND RELATED PREPARATION METHOD AND APPLICATION
  申请人：Elite Electronic Material(Zhongshan) Co., Ltd.

  公开号：US20170022228A1

  公开（公告）日：2017-01-26

  Provided is a phosphaphenanthrene-based compound represented by the following chemical structure: The phosphaphenanthrene-based compound can be added in a resin composition and made into a prepreg or resin film. The prepreg or resin film made from such resin composition has low coefficient of thermal expansion, low dielectric constant and dissipation factor, and flame retardancy, thereby being suitable for copper-clad laminate or printed circuit board.

  提供的是以下化学结构所代表的基于磷菲的化合物： 这种基于磷菲的化合物可以添加到树脂组合物中，并制成预浸料或树脂薄膜。从这种树脂组合物制成的预浸料或树脂薄膜具有低热膨胀系数、低介电常数和介质损耗因子，以及阻燃性，因此适用于铜覆层层压板或印刷电路板。
• Catalyst for decarbonylation reaction
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0826658A1

  公开（公告）日：1998-03-04

  A catalyst composed of an organic phosphorus compound having a trivalent or pentavalent phosphorus atom and at least one carbon-phosphorus bonding or a combination of the organic phosphorus compound and a halogen atom-containing compound is effective for decarbonylation, that is, for releasing carbon monoxide from a compound containing a moiety of -CO-CO-O- in its molecular structure.

  一种由含有三价或五价磷原子的有机磷化合物和至少一个碳-磷键合或有机磷化合物与含卤原子的化合物的组合构成的催化剂对于脱羰基作用是有效的，即从含有分子结构中的-CO-CO-O-基团的化合物中释放一氧化碳。
• Use of Silver Carbonate in the Wittig Reaction
  作者：Lukas Jedinak、LaToya Rush、Mijoon Lee、Dusan Hesek、Jed F. Fisher、Bill Boggess、Bruce C. Noll、Shahriar Mobashery

  DOI：10.1021/jo401972a

  日期：2013.12.6

  nonstabilized phosphorus ylides with various carbonyl compounds in the presence of silver carbonate is reported. Wittig olefination of aromatic, heteroaromatic, and aliphatic aldehydes (yields >63%) and a ketone (yield 42%) are demonstrated. These reactions proceed overnight at room temperature, under weakly basic conditions, and as such extend the applicability of the Wittig reaction to base-sensitive

  报道了在碳酸银存在下通过稳定、半稳定和不稳定的磷叶立德与各种羰基化合物的偶联来有效合成烯烃。展示了芳香族、杂芳香族和脂肪族醛（产率 >63%）和酮（产率 42%）的 Wittig 烯化。这些反应在室温、弱碱性条件下进行过夜，因此扩展了 Wittig 反应对碱敏感反应物的适用性。
• Palladium-Catalyzed Aminomethylative Oppolzer-Type Cyclization of Enynes: Access to Aminomethylated Benzofulvenes
  作者：Renbin Huang、Bangkui Yu、Renren Li、Hanmin Huang

  DOI：10.1021/acs.orglett.1c03720

  日期：2021.12.17

  A novel palladium-catalyzed Oppolzer-type cyclization reaction aided by the aminomethyl cyclopalladated complex has been developed, which provides rapid access to functionalized benzofulvenes with excellent stereoselectivity. The corresponding products can undergo Diels–Alder reaction with maleimides, providing a series of complex polycyclic compounds with excellent regio- and stereoselectivities.

  已开发出一种由氨甲基环钯配合物辅助的新型钯催化 Oppolzer 型环化反应，可快速获得具有优异立体选择性的官能化苯并富烯。相应的产物可以与马来酰亚胺发生狄尔斯-阿尔德反应，提供一系列具有优异区域和立体选择性的复杂多环化合物。
• [EN] PROCESS FOR PREPARATION OF ALUMINUM SALT OF PHOSPHONIC ACID ESTER<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN SEL D'ALUMINIUM D'UN ESTER D'ACIDE PHOSPHONIQUE
  申请人：ICL IP AMERICA INC

  公开号：WO2013077989A1

  公开（公告）日：2013-05-30

  There is provided herein a process for the preparation of aluminum salts of phosphonic acid esters by reacting phosphonic acid diesters with aluminum hydroxide in the presence of a catalyst. The catalyst is selected from the group consisting of a phase transfer catalyst, a thermally stable tertiary amine having a boiling point higher than about 140°C, a thermally stable tertiary phosphine having a boiling point higher than 140°C and combinations thereof. The aluminum phosphonates prepared can be used for making flame retarded thermoplastic polymers.

  本文提供了一种制备磷酸酯铝盐的方法，通过在催化剂存在下将磷酸二酯与氢氧化铝反应。催化剂选自相转移催化剂、热稳定的沸点高于约140°C的三级胺、热稳定的沸点高于140°C的三级膦和它们的组合。制备的铝磷酸盐可用于制备阻燃热塑性聚合物。

表征谱图