6-氨基-2,4(3H,5H)-嘧啶二酮 | 14436-34-1

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 6-氨基-2,4(3H,5H)-嘧啶二酮
• 英文名称: barbituric acid
• 英文别名: Imino-4-uracil；Barbitursaeure-4-imin；2,4-Dioxo-6-imino-1,3-diaza-hexahydrobenzol；2,6-Dioxo-4-imino-hexahydropyrimidin；6-amino-1H-pyrimidine-2,4-dione；6-amino-2,4(1H,3H)-pyrimidinedione；Pyrimidine, 2,4-dihydroxy-6-amino；6-imino-1,3-diazinane-2,4-dione
• CAS: 14436-34-1
• 化学式: C₄H₅N₃O₂
• 分子量: 127.103
• InChiKey: BLOCGUWRFAOSFW-UHFFFAOYSA-N

物化性质

• 密度：
  1.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯乙醛 、 6-氨基-2,4(3H,5H)-嘧啶二酮 在 碳酸氢钠 作用下， 以 水 为溶剂， 反应 1.0h， 生成 2,4-二羟基吡咯[2,3-d]嘧啶
  参考文献：
  名称：

  2,4-二氯-7H-吡咯并[2,3-D]嘧啶的制备方法

  摘要：

  本申请适用于药物合成技术领域，提供了2,4‑二氯‑7H‑吡咯并[2,3‑D]嘧啶的制备方法，以6‑氨基尿嘧啶为起始原料，在碳酸氢钠的作用下与氯乙醛反应，反应温度控制为45～65℃，得中间体；将所述中间体在N,N‑二异丙基乙胺的催化作用下与三氯氧磷反应，反应温度控制为75～90℃，经析晶、溶解提取以及脱色析晶处理而得。本申请可抑制胶状物和颜色杂质的生成，显著简化了后处理和精制工序的操作，生产效率提高，其生产经济性较好，可实现30公斤级生产制备的总收率大于50％，产品纯度达100％，外观白色，完全满足下游产品使用质量需求。

  公开号：

  CN114230572A
• 作为产物：
  描述：

  氰乙酰脲 、 magnesium methanolate 生成 6-氨基-2,4(3H,5H)-嘧啶二酮
  参考文献：
  名称：

  Lund, Chemische Berichte, 1936, vol. 69, p. 1621,1625

  摘要：

  DOI：

文献信息

• Resident Contact With Family and Friends Following Nursing Home Admission
  作者：Cynthia L. Port、Ann L. Gruber-Baldini、Lynda Burton、Mona Baumgarten、J. Richard Hebel、Sheryl Itkin Zimmerman、Jay Magaziner

  DOI：10.1093/geront/41.5.589

  日期：2001.10.1

  Purpose: This study explored factors that are related to the level of contact (number of visits and calls) between newly admitted nursing home residents and their family and friends. In addition to reexamining factors studied previously, several new factors were explored: contact level prior to nursing home placement, dementia status, and resident race. Design and Methods: Interviews were conducted with the significant others of 1,441 residents from a representative sample of nursing homes in Maryland. Results: Contact decreased by approximately half following admission, compared to reported preadmission contact. Rates of contact are positively related to nonuse of Medicaid, kinship closeness, support network proximity, nondemented status, and White race. After controlling for preadmission contact, postadmission contact is positively associated with kinship closeness, support network proximity, nondemented status, and White race. Implications: The study identifies factors that are useful to consider when designing interventions to increase family involvement with nursing home residents.

  目的：本研究探讨了与新入院护理院居民及其家人和朋友之间接触水平（访问和通话次数）相关的因素。除了重新审视之前研究的因素外，还探讨了几个新因素：入住护理院前的接触水平、痴呆状态和居民种族。设计与方法：对马里兰州一代表性样本中的1,441名居民的亲属进行了访谈。结果：入院后，接触频率相比入院前减少了约一半。接触频率与未使用医疗补助、亲属关系亲密度、支持网络的接近性、非痴呆状态和白人种族呈正相关。在控制了入院前接触后，入院后的接触与亲属关系亲密度、支持网络接近性、非痴呆状态和白人种族呈正相关。影响：本研究确定了在设计干预措施以增加家属与护理院居民的参与时需要考虑的有用因素。
• A computational scan for U12-dependent introns in the human genome sequence
  作者：Aaron Levine、Richard Durbin

  DOI：10.1093/nar/29.19.4006

  日期：2001.10.1

  U12-dependent introns are found in small numbers in most eukaryotic genomes, but their scarcity makes accurate characterisation of their properties challenging. A computational search for U12-dependent introns was performed using the draft version of the human genome sequence. Human expressed sequences confirmed 404 U12-dependent introns within the human genome, a 6-fold increase over the total number of non-redundant U12-dependent introns previously identified in all genomes. Although most of these introns had AT-AC or GT-AG terminal dinucleotides, small numbers of introns with a surprising diversity of termini were found, suggesting that many of the non-canonical introns found in the human genome may be variants of U12‐dependent introns and, thus, spliced by the minor spliceosome. Comparisons with U2-dependent introns revealed that the U12-dependent intron set lacks the ‘short intron’ peak characteristic of  U2‐dependent introns. Analysis of this U12‐dependent intron set confirmed reports of a biased distribution of U12-dependent introns in the genome and allowed the identification of several alternative splicing events as well as a surprising number of apparent splicing errors. This new larger reference set of U12-dependent introns will serve as a resource for future studies of both the properties and evolution of the U12 spliceosome.

  在大多数真核生物基因组中发现的 U12 依赖性内含子数量很少，但它们的稀缺性使得准确表征其特性具有挑战性。使用人类基因组序列草稿版本对 U12 依赖性内含子进行计算搜索。人类表达序列证实了人类基因组内有 404 个 U12 依赖性内含子，比之前在所有基因组中鉴定的非冗余 U12 依赖性内含子总数增加了 6 倍。尽管大多数内含子具有 AT-AC 或 GT-AG 末端二核苷酸，但仍发现了少量具有令人惊讶的末端多样性的内含子，这表明在人类基因组中发现的许多非规范内含子可能是 U12 依赖性内含子的变体内含子，因此由小剪接体剪接。与 U2 依赖性内含子的比较表明，U12 依赖性内含子组缺乏 U2 依赖性内含子的“短内含子”峰特征。对这个 U12 依赖性内含子集的分析证实了基因组中 U12 依赖性内含子的偏向分布的报告，并允许鉴定几个可变剪接事件以及数量惊人的明显剪接错误。这个新的更大的 U12 依赖性内含子参考集将作为未来研究 U12 剪接体的特性和进化的资源。
• In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst
  作者：Vinuta Kamat、Delicia A. Barretto、Boja Poojary、Amit Kumar、Veerabhadragouda B. Patil、Shanavaz Hamzad

  DOI：10.1016/j.bioorg.2023.107085

  日期：2024.2

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• Photochemical reactions of 5-fluoropyrimidine bases with selected alkylamines
  作者：Anna Kanciurzewska、Mateusz Raczkowski、Krzysztof Ciszewski、Lech Celewicz

  DOI：10.1016/s0040-4039(02)02654-0

  日期：2003.1

  Novel photochemical reactions between 5-fluoropyrimidine bases and primary alkylamines are described. Photoreaction of 5-fluorouracil with alkylamines in aqueous solution (pH>8) leads to 5-alkylaminouracils as the main photoproducts. Similarly, photoreaction of 5-fluorocytosine with alkylamines yields 5-alkylaminocytosines. (C) 2003 Elsevier Science Ltd. All rights reserved.
• DE117922
  申请人：——

  公开号：——

  公开（公告）日：——