N-叔丁氧羰基-5-溴吲哚 | 182344-70-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 吲哚类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: N-叔丁氧羰基-5-溴吲哚
• 中文别名: 1-BOC-5-溴吲哚；N-Boc-5-溴吲哚；5-溴吲哚-1-羧酸叔丁酯；N-BOC-5-溴吲哚
• 英文名称: 5-bromo-indole-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 5-bromo-1H-indole-1-carboxylate；N-Boc-5-bromoindole；tert-butyl 5-bromoindole-1-carboxylate；5-bromo-1-(tert-butoxycarbonyl)-1H-indole；N-tert-butoxycarbonyl-5-bromoindole
• CAS: 182344-70-3
• 化学式: C₁₃H₁₄BrNO₂
• 分子量: 296.164
• InChiKey: PBWDRTGTQIXVBR-UHFFFAOYSA-N

物化性质

• 熔点：
  56-57 °C(lit.)
• 沸点：
  367.9±34.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)
• 稳定性/保质期：
  常温常压下稳定，避免与强氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2933990090
• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  密封储存，应存放在阴凉干燥的库房中。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 1-BOC-5-bromoindole
Synonyms: tert-Butyl 5-bromo-1H-indole-1-carboxylate

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

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Section 3. Composition/information on ingredients.
Ingredient name: 1-BOC-5-bromoindole
CAS number: 182344-70-3

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C13H14BrNO2
Molecular weight: 296.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-叔丁氧羰基-5-溴吲哚 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以92%的产率得到5-溴吲哚
  参考文献：
  名称：

  简单且选择性地去除吲哚、吡咯、吲唑和咔啉上的叔丁氧羰基 (Boc) 保护基团

  摘要：

  摘要 使用催化量的 NaOMe 作为碱在无水 MeOH 中，以高产率实现了吲哚、吡咯、吲唑和咔啉上的 N-叔丁氧基羰基 (N-Boc) 基团的高选择性和高效脱保护，在环境温度。IICT 通讯编号 060512。

  DOI：

  10.1080/00397910601033724
• 作为产物：
  描述：

  5-溴-N-(叔丁氧羰基)吲哚2-硼酸 在 三苯基膦双(三氟甲磺酰亚胺)金 、 水 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以85%的产率得到N-叔丁氧羰基-5-溴吲哚
  参考文献：
  名称：

  Gold-Catalyzed Proto- and Deuterodeboronation

  摘要：

  A mild gold-catalyzed protodeboronation reaction, which does not require acid or base additives and can be carried out in "green" solvents, is described. As a result, the reaction is very functional-group-tolerant, even to acid- and base-sensitive functional groups, and should allow for the boronic acid group to be used as an effective traceless directing or blocking group. The reaction has also been extended to deuterodeboronations for regiospecific ipso-deuterations of aryls and heteroaryls from the corresponding organoboronic acid. Based on density functional theory calculations, a mechanism is proposed that involves nucleophilic attack of water at boron followed by rate-limiting B-C bond cleavage and facile protonolysis of a Au-sigma-phenyl intermediate.

  DOI：

  10.1021/acs.joc.5b01041
• 作为试剂：
  描述：

  1-(3-氟苯基)吡唑-4-甲醛 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 bis(1,5-cyclooctadiene)diiridium(I) dichloride 、 三苯基膦 、 异丙醇 、 (S)-4,12-二(二苯基膦)溴[2.2]对环芳 、 N-叔丁氧羰基-5-溴吲哚 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 18.75h， 生成 tert-butyl 3-(3-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)but-3-en-2-yl)-3-hydroxyazetidine-1-carboxylate
  参考文献：
  名称：

  2-丙醇介导的对映选择性铱催化二烯与氧杂环丁酮和 N-酰基氮杂环丁酮的还原偶联

  摘要：

  环金属化铱-PhanePhos 配合物催化 2-丙醇介导的 2-取代二烯与氧杂环丁酮和 N-酰基氮杂环丁酮的还原偶联，形成支链同烯丙基氧杂环丁醇和氮杂环丁醇，具有出色的区域选择性和对映选择性控制，且无需拉紧环的 C−C 裂解。这项工作代表了对称酮对映选择性加成的首次系统研究。

  DOI：

  10.1002/anie.202115959

文献信息

• Direct arylation of strong aliphatic C–H bonds
  作者：Ian B. Perry、Thomas F. Brewer、Patrick J. Sarver、Danielle M. Schultz、Daniel A. DiRocco、David W. C. MacMillan

  DOI：10.1038/s41586-018-0366-x

  日期：2018.8

  C(sp3)–heteroatom bonds from strong C–H bonds has been reported6,7. Additionally, valuable technologies have been developed for the formation of carbon–carbon bonds from the corresponding C(sp3)–H bonds via substrate-directed transition-metal C–H insertion8, undirected C–H insertion by captodative rhodium carbenoid complexes9, or hydrogen atom transfer from weak, hydridic C–H bonds by electrophilic

  尽管过渡金属催化的交叉偶联方法取得了广泛的成功，但 sp3 杂化碳原子的反应仍然存在相当大的局限性，大多数方法依赖于预官能化的烷基金属或溴化物偶联伙伴 1,2。尽管使用天然官能团（例如，羧酸、烯烃和醇）通过扩大潜在原料的范围提高了此类转化的整体效率3-5，但碳氢（C-H）键的直接官能化——有机分子中最丰富的部分——代表了一种更理想的分子构建方法。近年来，已经报道了从强 C-H 键形成 C(sp3)-杂原子键的一系列令人印象深刻的反应6,7。此外，已经开发出有价值的技术，用于通过底物导向的过渡金属 C-H 插入 8、通过捕获性铑卡宾配合物 9 的非定向 C-H 插入或氢原子转移从相应的 C(sp3)-H 键形成碳-碳键通过亲电开壳物质 10-14 从弱的氢化 C-H 键中提取。尽管取得了这些进展，但尚未实现用于将强中性 C(sp3)-H 键与芳基亲电试剂偶联的温和通用平台。在这里，我们描述了
• Synthesis of α-Aryl Nitriles through Palladium-Catalyzed Decarboxylative Coupling of Cyanoacetate Salts with Aryl Halides and Triflates
  作者：Rui Shang、Dong-Sheng Ji、Ling Chu、Yao Fu、Lei Liu

  DOI：10.1002/anie.201006763

  日期：2011.5.2

  Worth its salt: The palladium‐catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono‐ and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α‐aryl nitriles and has good functional group tolerance. S‐Phos=2‐(2,6‐dimethoxybiphenyl)dicyclohexylphosphine)

  值得其盐：描述了氰基乙酸盐及其与芳基氯化物，溴化物和三氟甲磺酸酯的钯催化的脱羧偶联反应（参见方案）。该反应对于制备各种α-芳基腈具有潜在的实用性，并具有良好的官能团耐受性。S-Phos = 2-（（2,6-二甲氧基联苯）二环己基膦），Xant-Phos = 4,5-双（二苯基膦基）-9,9-二甲基x吨。
• Process for preparation of benzo[f]quinolinones
  申请人：Eli Lilly and Company

  公开号：US05578724A1

  公开（公告）日：1996-11-26

  A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase and their preparation is disclosed.

  一系列苯醌啉-3-酮类药物在治疗由I型和II型5α-还原酶引起的疾病方面具有有效性，并且其制备方法已被披露。
• Palladium-Catalyzed Cross-Coupling Reaction of Tricyclopropylbismuth with Aryl Halides and Triflates
  作者：Alexandre Gagnon、Martin Duplessis、Pamela Alsabeh、Francis Barabé

  DOI：10.1021/jo702377h

  日期：2008.5.1

  The palladium-catalyzed cross-coupling reaction of tricyclopropylbismuth with aryl and heterocyclic halides and triflates is reported. The reaction tolerates numerous functional groups and does not require anhydrous conditions. The method was successfully extended to the cross-coupling of triethylbismuth.

  报道了钯催化的三环丙基铋与芳基和杂环卤化物以及三氟甲磺酸酯的交叉偶联反应。该反应可耐受许多官能团，并且不需要无水条件。该方法已成功地扩展到三乙基铋的交叉偶联。
• Decarboxylative Cross-Coupling of Azoyl Carboxylic Acids with Aryl Halides
  作者：Fengzhi Zhang、Michael F. Greaney

  DOI：10.1021/ol1019597

  日期：2010.11.5

  Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported. Under a bimetallic system of catalytic palladium and a stoichiometric silver carbonate, a variety of (hetero)arylated azoles can be prepared in excellent yield.

  据报道噻唑和恶唑-5-羧酸与芳基卤的脱羧交叉偶联。在催化钯和化学计量的碳酸银的双金属体系下，可以以高收率制备各种（杂）芳基化的唑。