Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/
/HUMAN EXPOSURE STUDIES/ Ten volunteers (males and females) each had their hair dyed 13 times at intervals of 3-6 wk. Each volunteer used a single commercial preparation throughout the study. /Five of the preparations contained 2-hydroxy-4-aminotoluene./ ...Lymphocytes of the hair-dyed volunteers and of ten controls matched for age and sex were scored for chromosomal aberrations. The incidence of aberrations did not differ significantly between the controls and the hair-dyed volunteers at any of the nine sampling times.
/HUMAN EXPOSURE STUDIES/ A modified Draize repeat insult patch test (RIPT) procedure was used to evaluate the irritation and sensitization potential of two aqueous solutions, each containing 2% of 4-amino-2-hydroxytoluene as supplied. An initial challenge (100% applied for 1 hr) was made to aid in the interpretation of the challenge following the rest period. For the induction exposure, semiocclusive patches containing 0.3 ml of the solution were applied to the same site on the upper arm of each subject on Mondays, Wednesdays, and Fridays for 3 consecutive weeks. The first solution for induction was a 3.0% v/v aqueous solution and the second was a 10% w/v aqueous solution. Patches were left in place for 24 hr and scored 48 or 72 hr after application. The challenge was made after a 2 wk nontreatment period. A patch containing 100% of the test solution was applied to a previously untreated site for 1 hr. Sites were scored 48 and 96 hr after application. Another challenge patch was also applied simultaneously to the induction site using the induction concentration. Twenty-three of the 27 subjects completed testing with the first solution. The initial challenge produced 21 negative and 5 slight reactions; the induction period elicited reactions from one subject only, who had a score of 4 (maximum=7) at the sixth induction patch and was subsequently patched on a different site. The challenge solution produced 20 negative, 2 slight (score of 1), and 1 significant (score of 3) reactions. The significant reaction was seen in the same subject who had reacted during the induction phase. No reactions were produced by the challenge patch applied to the induction site. A rechallenge was conducted with 11 of the subjects at a naive site on the upper back using a concentration of 25% of the test solution; 10 negative (including the 1 patient with the significant reaction at challenge) and 1 slight reactions were observed. /It was/ concluded that the test solution had produced one case of significant dermatitis, although it was not reproduced at rechallenge. Thirty-one subjects completed testing with the second solution. The initial challenge failed to produce a reaction in any of the subjects. During the induction period, very slight reactions (scores of 1 or less) were observed in 4 subjects and strong reactions (scores of up to 3 and 5) in two subjects. Challenge at a previously untreated site produced two slight reactions and one strong reaction (scores of 5 at both 48 and 96 hr), the latter being a delayed challenge due to residual reactions from the induction phase. The challenge patches applied to the induction site produced three slight and two strong reactions; however, only one of these five subjects had a reaction when challenged at a previously untreated site. A rechallenge of two subjects produced one negative and one significant response, the latter being from one of those with a strong reaction to challenge at the induction site. In the investigator's opinion, two cases of significant dermatitis had been observed, one each during challenge and rechallenge; therefore, these were cases of induced contact allergic eczema.
/Percutaneous absorption of 5-amino-o-cresol in a hair dye was studied under the conditions of usage. Radiolabeled 5-amino-o-cresol was added to a commercial dye containing 0.69% non-radioactive 5-amino-o-cresol; the mixture was applied to dry hair of three volunteers, worked in to the hair mass for 5-8 min, and rinsed off after an additional 20 min; the urine samples were collected for as long as radioactivity was detected, approximately 144 hr. The total urinary excretion of radioactivity was 0.2% with 50% of the radioactivity excreted in 24 hr./
/A/ ...series of experiments /compared/ the skin permeability of a number of hair dyes obtained in two different laboratories. /Both pig skin (in vitro) and rat skin (in vivo) are permeable to 5-amino-o-cresol, the latter being more permeable.
A 94% recovery of radioactivity (corrected for incomplete excretion from internal application) in human urine after oral administration of radioactive 4-amino-2-hydroxytoluene /was reported/.
The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.
[EN] NEW CATIONIC DYES, KITS AND COMPOSITIONS THEREOF, AND PROCESS FOR DYEING KERATIN FIBERS<br/>[FR] NOUVEAUX COLORANTS CATIONIQUES, KITS ET COMPOSITIONS LES CONTENANT, ET PROCÉDÉ DE TEINTURE DE FIBRES KÉRATINIQUES
申请人：ALFA PARF GROUP S P A
公开号：WO2014202150A1
公开（公告）日：2014-12-24
The present invention relates to new cationic dyes of general formula (I) and (II): The invention also relates to kits and compositions for dyeing keratin fibers, which contain at least one of these dyes as well as to a process for dyeing keratin fibers using at least one of these dyes.
[EN] 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION<br/>[FR] OXINDOLES 3-3-DI-SUBSTITUES UTILISES EN TANT QU'INHIBITEURS DE L'INITIATION DE LA TRADUCTION
申请人：HARVARD COLLEGE
公开号：WO2005080335A1
公开（公告）日：2005-09-01
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxyphenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
Aprocess for the assembly of carbazolealkaloids has been developed on the basis of ring‐closingmetathesis (RCM) and ringrearrangement–aromatization (RRA) as the key steps. This method is based on allyl Grignard addition to isatin derivatives to provide smooth access to 2,2‐diallyl 3‐oxindole derivatives through a 1,2‐allyl shift. The diallyl derivatives were used as RCM precursors to afford a novel
Highly Ligand-Controlled Regioselective Pd-Catalyzed Aminocarbonylation of Styrenes with Aminophenols
作者：Tongyu Xu、Feng Sha、Howard Alper
DOI：10.1021/jacs.6b03161
日期：2016.5.25
Achieving chemo- and regioselectivity simultaneously is challenging in organic synthesis. Transition metal-catalyzed reactions are effective in addressing this problem by the diverse ligand effect on the catalyst center. Ligand-controlled regioselective Pd-catalyzed carbonylation of styrenes with aminophenols was realized, chemoselectively affording amides. Using a combination of boronic acid and 5-chlorosalicylic
