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喹啉
水杨醛
二溴甲烷
谷胱甘肽
L-乳酸
苯巴比妥
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百草枯
联苯烯

5-氨基-5-脱氧-2,3-O-(1-甲基亚乙基)-腺苷酸 | 21950-36-7

分子结构分类

有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类

中文名称

5-氨基-5-脱氧-2,3-O-(1-甲基亚乙基)-腺苷酸

中文别名

5'-氨基-5'-脱氧-2',3'-O-异丙叉腺苷

英文名称

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

英文别名

9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine；5'-deoxy-5'-amino-2',3'-O-isopropylidene adenosine；2',3'-O-isopropylidene-5'-amino-5'-deoxyadenosine；5’-amino-5’-deoxy-2’,3’-O-(isopropylidene)adenosine；5'-deoxy-5'-amino-2',3'-(1-methylethylidene)adenosine；9-((3aR,4R,6R,6aR)-6-aminomethyl-2,2-dimethyl-tetrahydro-furo[3,4-d]-1,3-dioxol-4-yl)-9H-purin-6-ylamine；5'-amino-5'-deoxy-2',3'-o-(1-methylethylidene)adenosine；5'-amino-2',3'-(O-isopropylidene)-5'-deoxyadenosine；5'-amino-2',3'-isopropylidene adenosine；5'-Amino-5'-deoxy-2',3'-O-(1-methylethylidene)-adenosine；9-[(3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]purin-6-amine

CAS

21950-36-7

化学式

C₁₃H₁₈N₆O₃

mdl

——

分子量

306.324

InChiKey

RGJLVQRLOVOJRF-WOUKDFQISA-N

BEILSTEIN

——

EINECS

——

物化性质

熔点：

202-203℃
沸点：

553.1±60.0 °C(Predicted)
密度：

1.80±0.1 g/cm3 (20 ºC 760 Torr)

计算性质

辛醇/水分配系数(LogP)：

-1.2
重原子数：

22
可旋转键数：

2
环数：

4.0
sp3杂化的碳原子比例：

0.62
拓扑面积：

123
氢给体数：

2
氢受体数：

8

安全信息

危险性防范说明：

P280,P305+P351+P338
危险性描述：

H302
储存条件：

2-8°C

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine	34245-48-2	C₁₃H₁₆N₈O₃	332.322
2',3'-异丙叉腺苷	2',3'-isopropylidene adenosine	362-75-4	C₁₃H₁₇N₅O₄	307.309
——	5'-deoxy-5'-chloro-2',3'-isopropylideneadenosine	24514-56-5	C₁₃H₁₆ClN₅O₃	325.755
——	((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl methanesulfonate	68179-90-8	C₁₄H₁₉N₅O₆S	385.401
2-(((3aR,4R,6R,6aR)-6-(6-氨基-9H-嘌呤-9-基)-2,2-二甲基四氢呋喃并[3,4-d][1,3]二氧代-4-基)甲基)异吲哚啉-1,3-二酮	5'-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2',3'-(1-methylethylidene)-5'-deoxyadenosine	80860-44-2	C₂₁H₂₀N₆O₅	436.427
N6-苯甲酰基-2',3'-O-异丙亚基腺苷	N-6-benzoyl-2',3'-O-isopropylideneadenosine	39947-04-1	C₂₀H₂₁N₅O₅	411.417
5'-O-(苄基磺酰基)-2',3'-O-异亚丙基腺苷	((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate	5605-63-0	C₂₀H₂₃N₅O₆S	461.499
——	N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine	40653-96-1	C₂₁H₂₃N₅O₇S	489.509
腺苷	adenosine	58-61-7	C₁₀H₁₃N₅O₄	267.244

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	9-((3aR,4R,6R,6aR)-6-((ethylamino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine	116700-92-6	C₁₅H₂₂N₆O₃	334.378
——	2-((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl)aminoethanol	1172048-17-7	C₁₅H₂₂N₆O₄	350.377
——	9-{(3aR,4R,6R,6aR)-6-[(2-chloroethylamino)methyl]-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-ylamine	1172048-09-7	C₁₅H₂₁ClN₆O₃	368.823
——	9-((3 aR,4R,6R,6aR)-6-((isopropylamino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine	——	C₁₆H₂₄N₆O₃	348.405
——	tert-butyl 4-((((3αR,4R,6R,6αR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-butanoate	58611-60-2	C₂₁H₃₂N₆O₅	448.522
——	5'-deoxy-5'-acetamido-2',3'-O-isopropylidene adenosine	32077-99-9	C₁₅H₂₀N₆O₄	348.362
——	tert-butyl (3-((((3αR,4R,6R,6αR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-propyl)carbamate	1346627-75-5	C₂₁H₃₃N₇O₅	463.537
——	3-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl-propan-2-ylamino]propan-1-ol	1394956-50-3	C₁₉H₃₀N₆O₄	406.485
——	ethenyl N-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl]carbamate	357928-44-0	C₁₆H₂₀N₆O₅	376.372
——	9-((3αR,4R,6R,6αR)-6-((benzylamino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine	58611-58-8	C₂₀H₂₄N₆O₃	396.449
——	N1-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N1-isopropylpropane-1,3-diamine	1381764-00-6	C₁₉H₃₁N₇O₃	405.5
——	(1S,3s)-3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutanecarbaldehyde	1380290-67-4	C₂₁H₃₀N₆O₄	430.507
——	(1S,3s)-methyl 3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutanecarboxylate	1380290-65-2	C₂₂H₃₂N₆O₅	460.533
——	ethyl 3-((1S,3r)-3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate	1380290-72-1	C₂₅H₃₈N₆O₅	502.614
——	benzyl N-[2-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl-(2-methylpropyl)amino]ethyl]carbamate	1381760-95-7	C₂₇H₃₇N₇O₅	539.635
——	1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea	1381761-28-9	C₂₇H₃₈N₈O₄	538.65
——	tert-butyl (((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(3-aminopropyl)carbamate	1381763-02-5	C₂₁H₃₃N₇O₅	463.537
——	N-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-3-bromobenzamide	——	C₂₀H₂₁BrN₆O₄	489.329
——	5'-N-[4-{(2S)-2-(N-tert-butoxycarbonyl)aminobutyric acid}]-tert-butyl ester-5'-deoxy-2',3'-O,O-(1-methyl ethylidene)adenosine	1227195-11-0	C₂₆H₄₁N₇O₇	563.654
——	1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(3-chlorophenyl)urea	1381764-02-8	C₂₆H₃₅ClN₈O₄	559.068
——	1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea	1381760-93-5	C₂₈H₄₀N₈O₄	552.677
——	N-benzyloxycarbonyl-N'-(2',3'-O-isopropylidene-5'-deoxyadenosin-5'-yl)sulfamide	213554-34-8	C₂₁H₂₅N₇O₇S	519.538
——	1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(3-ethylphenyl)urea	1381763-70-7	C₂₈H₄₀N₈O₄	552.677
——	1-[2-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl-(2-methylpropyl)amino]ethyl]-3-(4-tert-butylphenyl)urea	1381760-97-9	C₃₀H₄₄N₈O₄	580.731
——	(S)-tert-butyl 4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-(((benzyloxy)carbonyl)amino)butanoate	901776-52-1	C₂₉H₃₉N₇O₇	597.671
——	N-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl]-N-[3-[(4-tert-butylphenyl)carbamoylamino]propyl]formamide	1381761-54-1	C₂₈H₃₈N₈O₅	566.66
——	5'-N-propynylamino-N'-[4-{(2S)-2-(N-tert-butoxycarbonyl)aminobutyric acid}]tert-butyl ester-5-deoxy-2,3-O,O-(1-methylethylidene)adenosine	1227195-16-5	C₂₉H₄₃N₇O₇	601.703
——	1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(benzyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea	1381761-87-0	C₃₄H₄₄N₈O₄	628.775
——	5'-amino-5'-deoxy-2',3'-isopropylidene-inosine	471923-07-6	C₁₃H₁₇N₅O₄	307.309
——	2-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)propyl)isoindoline-1,3-dione	1381761-99-4	C₂₄H₂₇N₇O₅	493.522
——	N-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-3-(3-(4-(tert-butyl)phenyl)ureido)-N-ethylpropanamide	1381764-05-1	C₂₉H₄₀N₈O₅	580.687
——	1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)propyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea	1381763-73-0	C₂₇H₃₄ClF₃N₈O₄	627.066
5-氨基腺苷酸	5'-amino-5'-deoxyadenosine	14365-44-7	C₁₀H₁₄N₆O₃	266.26
——	N1-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N3-(5-(tert-butyl)-1H-benzo[d]imidazoI-2-yl)-N1-ethylpropane-1,3-diamine	1381762-94-2	C₂₉H₄₁N₉O₃	563.703
——	tert-butyl N-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl]-N-[2-[(4-tert-butylphenyl)carbamoylamino]ethyl]carbamate	1381760-77-5	C₃₁H₄₄N₈O₆	624.74
——	5'-deoxy-5'-acetamido-2',3'-O-isopropylidene inosine	——	C₁₅H₁₉N₅O₅	349.346
——	5'-<(3-aminooxypropyl)amino>-5'-deoxyadenosine	97187-25-2	C₁₃H₂₁N₇O₄	339.354
——	5'-N-Propargylamino-5'-deoxyadenosine	1383460-41-0	C₁₃H₁₆N₆O₃	304.308
——	5'-<(3-aminopropyl)amino>-5'-deoxyadenosine	81162-85-8	C₁₃H₂₁N₇O₃	323.355
——	9-((3aR,4R,6R,6aR)-6-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine	1380290-79-8	C₃₃H₄₆N₈O₃	602.78
——	tert-butyl (((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(3-(1,3-dioxoisoindolin-2-yl)propyl)carbamate	1381763-00-3	C₂₉H₃₅N₇O₇	593.64
——	9H-fluoren-9-ylmethyl N-[2-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methylamino]ethyl]carbamate	1362693-32-0	C₃₀H₃₃N₇O₅	571.636
——	5'-[di(3-aminopropyl)amino]-5'-deoxyadenosine	1346627-80-2	C₁₆H₂₈N₈O₃	380.45
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]butanamide	756818-83-4	C₁₄H₂₀N₆O₄	336.351
——	N-(5'-deoxyadenosin-5'-yl)sulfamide	29015-18-7	C₁₀H₁₅N₇O₅S	345.339
——	5'-deoxy-2',3'-O-(1-methylethylidene)-adenosine 5'-N-(N-tertbutoxycarbonyl-L-phenylalanyl)sulfamide	213554-35-9	C₂₇H₃₆N₈O₈S	632.698
——	1-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-3-ethylurea	756818-84-5	C₁₃H₁₉N₇O₄	337.338
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[(benzylamino)methyl]oxolane-3,4-diol	30765-12-9	C₁₇H₂₀N₆O₃	356.384
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-3-chloropropane-1-sulfonamide	1222486-94-3	C₁₃H₁₉ClN₆O₅S	406.85
——	5'-deoxy-5'-[(3-guanidinopropyl)][(3-aminopropyl)amino]adenosine	1346627-79-9	C₁₇H₃₀N₁₀O₃	422.49
——	5'-deoxy-5'-[di(3-guanidinopropyl)amino]adenosine	1346627-81-3	C₁₈H₃₂N₁₂O₃	464.531
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]cyclopropanesulfonamide	1422553-52-3	C₁₃H₁₈N₆O₅S	370.389
——	(2S)-2-amino-5-[2-aminoethyl-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]amino]pentanoic acid	1381760-74-2	C₁₇H₂₈N₈O₅	424.46
——	5'-[(3(S)-3-amino-3-carboxypropyl)][(3-aminopropyl)amino]-5'-deoxyadenosine	1346627-76-6	C₁₇H₂₈N₈O₅	424.46
——	5'-[(3-carboxypropyl)][(3-guanidinopropyl)amino]-5'-deoxyadenosine	1346627-78-8	C₁₈H₂₉N₉O₅	451.486
——	(2S)-2-amino-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]-methyl]-3-hydroxypropanamide	1422553-09-0	C₁₃H₁₉N₇O₅	353.338
——	5'-N-5-guanidinopentyloamino-N'-[4-(2S)-(2-aminobutyric acid)]-5'-deoxyadenosine	1227243-99-3	C₂₀H₃₄N₁₀O₅	494.554
——	5'-N-4-huanidinobutylamino-N'-[4-(2S)-(2-aminobutyric acid)]-5'-deoxyadenosine	1227243-98-2	C₁₉H₃₂N₁₀O₅	480.527
——	tert-butyl (((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(3-((5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)amino)propyl)carbamate	1381763-03-6	C₃₂H₄₅N₉O₅	635.767
——	benzyl N-[3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]propyl]carbamate	1394955-78-2	C₂₁H₂₇N₇O₅	457.489
——	5'-N-3-guanidinopropylamino-N'-[4-(2S)-(2-aminobutyric acid)]-5'-deoxyadenosine	1227243-97-1	C₁₈H₃₀N₁₀O₅	466.5
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[(4-prop-2-ynoxyphenyl)methylamino]-methyl]oxolane-3,4-diol	1222438-54-1	C₂₀H₂₂N₆O₄	410.432
——	6-amino-9-[(2R,3R,4S,5R)-5-[[bis(2-methoxyethyl)sulfamoylamino]methyl]-3,4-dihydroxyoxolan-2-yl]purine	1222661-03-1	C₁₆H₂₇N₇O₇S	461.499
——	5’-deoxy-5’-N-(diethylphosphonoacetyl)adenosine	677025-69-3	C₁₆H₂₅N₆O₇P	444.384
——	N-[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]methyl]phenyl]acetamide	1422553-34-1	C₁₉H₂₃N₇O₄	413.436
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[(4-phenylmethoxyphenyl)methylamino]methyl]oxolane-3,4-diol	1222686-94-3	C₂₄H₂₆N₆O₄	462.508
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-4-methylpiperazine-1-sulfonamide	1422553-47-6	C₁₅H₂₄N₈O₅S	428.472
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[(3,4-dimethoxyphenyl)methylamino]methyl]oxolane-3,4-diol	1222632-45-2	C₁₉H₂₄N₆O₅	416.437
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-methyl-1-vinylpyrazol-4-yl]methylamino]-methyl]oxolane-3,4-diol	1422553-35-2	C₁₇H₂₂N₈O₃	386.413
——	(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(pyridin-2-yl)propyl)amino)butanoic acid	1373432-68-8	C₂₂H₃₀N₈O₅	486.531
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[(4-pyrazol-1-ylphenyl)methylamino]methyl]oxolane-3,4-diol	1222451-10-6	C₂₀H₂₂N₈O₃	422.446
——	1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea	1381760-94-6	C₂₅H₃₆N₈O₄	512.612
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-1-methylpyrazole-4-sulfonamide	1422553-58-9	C₁₄H₁₈N₈O₅S	410.414
——	1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(2-hydroxyethyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea	1381764-25-5	C₂₆H₃₈N₈O₅	542.638
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-4-methylbenzenesulfonamide	——	C₁₇H₂₀N₆O₅S	420.449
——	5'-[[(3S)-3-amino-3-carboxypropyl][(4-guanidinophenyl)methyl]amino]-5'-deoxyadenosine	1346627-77-7	C₂₂H₃₀N₁₀O₅	514.544
——	2-acetamido-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-3-methyl-3-sulfanylbutanamide	291755-49-2	C₁₇H₂₅N₇O₅S	439.495
——	1-[2-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-ethylamino]ethyl]-3-(4-tert-butylphenyl)urea	1381760-68-4	C₂₅H₃₆N₈O₄	512.612
——	3-(5′-amino-5′-deoxyadenosine)-4-butylamino-cyclobut-3-ene-1,2-dione	1514901-15-5	C₁₈H₂₃N₇O₅	417.425
——	3-(5′-amino-5′-deoxyadenosine)-4-(hexylamino)cyclobut-3-ene-1,2-dione	1514901-17-7	C₂₀H₂₇N₇O₅	445.478
——	2-[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-methyl]phenoxy]-N-pyridin-2-ylacetamide	1222677-39-5	C₂₄H₂₆N₈O₅	506.521
——	ethyl 1-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfamoyl]pyrrolidine-3-carboxylate	1422553-55-6	C₁₇H₂₅N₇O₇S	471.494
化合物55	FED1	1381761-52-9	C₂₇H₄₀N₈O₄	540.666
——	1-[2-[4-aminobutyl-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]amino]ethyl]-3-(4-tert-butylphenyl)urea	1381761-07-4	C₂₇H₄₁N₉O₄	555.68
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-4-cyanobenzenesulfonamide	1422553-54-5	C₁₇H₁₇N₇O₅S	431.432
——	1-[2-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-(2-methylpropyl)amino]ethyl]-3-(4-tert-butylphenyl)urea	1381760-98-0	C₂₇H₄₀N₈O₄	540.666
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-N-[3-[(4-tert-butylphenyl)carbamoylamino]propyl]formamide	1381761-55-2	C₂₅H₃₄N₈O₅	526.596
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[(3-propan-2-yloxynaphthalen-2-yl)methylamino]methyl]oxolane-3,4-diol	1222384-12-4	C₂₄H₂₈N₆O₄	464.524
——	2-[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-methyl]phenoxy]-N-(1,3-thiazol-2-yl)acetamide	1222500-81-3	C₂₂H₂₄N₈O₅S	512.549
——	1-[2-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]ethyl]-3-(4-tert-butylphenyl)urea	1381760-64-0	C₂₆H₃₈N₈O₄	526.639
——	1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(benzyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea	1381761-88-1	C₃₁H₄₀N₈O₄	588.71
——	2-[2-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-methyl]phenoxy]-1-piperidin-1-ylethanone	1224616-20-9	C₂₄H₃₁N₇O₅	497.554
——	N-[[5-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-methyl]furan-2-yl]methyl]-N-methylmethanesulfonamide	1222675-96-8	C₁₈H₂₅N₇O₆S	467.506
——	(2S)-2-amino-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfamoyl]-3-phenylpropanamide	——	C₁₉H₂₄N₈O₆S	492.516
——	(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(pyridin-2-ylmethyl)amino)butanoic acid	1373432-67-7	C₂₀H₂₆N₈O₅	458.477
——	3-(5′-amino-5′-deoxyadenosine)-4-(cyclopentylamino)-cyclobut-3-ene-1,2-dione	1514901-12-2	C₁₉H₂₃N₇O₅	429.436
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[2-[(2,4-dichlorophenyl)methoxy]phenyl]methylamino]methyl]oxolane-3,4-diol	1222661-55-3	C₂₄H₂₄Cl₂N₆O₄	531.398
——	N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-5-methylthiophene-2-sulfonamide	1222540-31-9	C₁₅H₁₈N₆O₅S₂	426.477
——	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[(6-methoxy-1,3-benzodioxol-5-yl)methylamino]methyl]oxolane-3,4-diol	1222399-92-9	C₁₉H₂₂N₆O₆	430.42
——	(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((E)-3-(2-nitrophenyl)allyl)amino)butanoic acid	901776-10-1	C₂₃H₂₈N₈O₇	528.525

反应信息

作为反应物：

描述：

5-氨基-5-脱氧-2,3-O-(1-甲基亚乙基)-腺苷酸在三乙酰氧基硼氢化钠作用下，以 1,2-二氯乙烷为溶剂，以33%的产率得到1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

参考文献：

名称：

[EN] MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF
[FR] MODULATEURS D'HISTONE MÉTHYLTRANSFÉRASE ET LEURS PROCÉDÉS D'UTILISATION

摘要：

公开号：

WO2012082436A3
作为产物：

描述：

2',3'-异丙叉腺苷在一水合肼、三苯基膦、偶氮二甲酸二乙酯作用下，以四氢呋喃、乙醇为溶剂，反应 4.0h，生成 5-氨基-5-脱氧-2,3-O-(1-甲基亚乙基)-腺苷酸

参考文献：

名称：

AdoMet依赖性3-氨基-3-羧丙基转移酶的抑制剂及其作为蛋白质亲和色谱的配体的用途

摘要：

从无细胞描述了潜在的亲和配体的筛选和参与β-内酰胺类抗生素诺卡霉素A生物合成的S-腺苷甲硫氨酸依赖性3-氨基-3-羧丙基转移酶的两阶段亲和纯化的发展。诺卡氏菌亚种提取物。tsuyamanesis。该蛋白质对离子交换和盐效应特别敏感，因此需要在最终纯化中使用一对中性配体。

DOI：

10.1016/s0040-4020(98)01004-7

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文献信息

Chemo- and Site-Selective Alkyl and Aryl Azide Reductions with Heterogeneous Nanoparticle Catalysts

作者：Venkatareddy Udumula、S. Hadi Nazari、Scott R. Burt、Madher N. Alfindee、David J. Michaelis

DOI：10.1021/acscatal.6b01217

日期：2016.7.1

to generating new leads for drug discovery. Herein, we show that heterogeneous nanoparticle catalysts enable site-selective monoreduction of polyazide substrates for the generation of aminoglycoside antibiotic derivatives. The nanoparticle catalysts are highly chemoselective for reduction of alkyl and aryl azides under mild conditions and in the presence of a variety of easily reduced functional groups

生物活性天然产物的位点选择性修饰是产生用于药物发现的新线索的有效方法。在这里，我们表明，异质纳米颗粒催化剂能够实现聚叠氮化物底物的位点选择性单还原，以生成氨基糖苷类抗生素衍生物。纳米颗粒催化剂在温和条件下和在各种容易还原的官能团存在下对烷基和芳基叠氮化物的还原具有高度的化学选择性。已显示出用于单叠氮化物还原的高区域选择性有利于空间上受阻最小的叠氮化物的还原。我们假设观察到的选择性源自较少受阻的叠氮化物基团与纳米颗粒催化剂表面相互作用的更大能力。
A general Staudinger protocol for solution-phase parallel synthesis

作者：Craig W Lindsley、Zhijian Zhao、Randall C Newton、William H Leister、Kimberly A Strauss

DOI：10.1016/s0040-4039(02)00827-4

日期：2002.6

The Staudinger reaction has been adapted for parallel synthesis by the application of fluorous-tethered triphenyl phosphine. The fluorous-tethered triphenylphosphine is expediently removed in parallel by FluoroFlash™ SPE columns to afford functionalized amines in high yields and purities.

施陶丁格反应已通过应用氟链三苯膦进行了平行合成。方便地通过Fluoro Flash ™SPE色谱柱并行除去氟系三苯膦，从而以高收率和纯度提供官能化胺。
[EN] NOVEL HISTONE METHYLTRANSFERASE INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS D'HISTONE MÉTHYLTRANSFÉRASES

申请人：UNIV FREIBURG ALBERT LUDWIGS

公开号：WO2021053158A1

公开（公告）日：2021-03-25

The present invention relates to novel compounds of formula (I) as defined herein. The compounds are inhibitors of histone methyltransferases of the seven-beta-strand family, in particular of KMT9.

本发明涉及式(I)定义的新的化合物。这些化合物是七-β-链家族组蛋白甲基转移酶的抑制剂，特别是KMT9的抑制剂。
Chemo-selective Rh-catalysed hydrogenation of azides into amines

作者：Mattia Ghirardello、Helene Ledru、Abhijit Sau、M. Carmen Galan

DOI：10.1016/j.carres.2020.107948

日期：2020.3

Rh/Al2O3 can be used as an effective chemo-selective reductive catalyst that combines the mild conditions of catalytic hydrogenation with high selectivity for azide moieties in the presence of other hydrogenolysis labile groups such as benzyl and benzyloxycarbonyl functionalities. The practicality of this strategy is exemplified with a range of azide-containing carbohydrate and amino acid derivatives

Rh / Al2O3可以用作有效的化学选择性还原催化剂，在存在其他氢解不稳定基团（例如苄基和苄氧羰基官能团）的情况下，将催化氢化的温和条件与对叠氮化物部分的高选择性结合在一起。该策略的实用性以一系列含叠氮化物的碳水化合物和氨基酸衍生物为例。
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

作者：Prakash G. Jagtap、Garry J. Southan、Erkan Baloglu、Siya Ram、Jon G. Mabley、Anita Marton、Andrew Salzman、Csaba Szabó

DOI：10.1016/j.bmcl.2003.10.007

日期：2004.1

A series of novel 4-(N-acyl)-2,3-dihydro-1H-isoindol-1-ones have been prepared from methyl-3-nitro-2-methylbenzoate and linked through various spacers to the adenosine derivatives 11 and 12. We found that potent inhibition of poly(ADP-ribose)polymerase-1 (PARP-1) was achieved when isoindolinone was linked to adenosine by a spacer group of a specific length. Introduction of piperazine and succinyl linkers

由3-硝基-2-甲基苯甲酸甲酯制备了一系列新颖的4-（N-酰基）-2,3-二氢-1H-异吲哚-1-酮，并通过各种间隔基连接到腺苷衍生物11和12上。我们发现，当异吲哚啉酮通过特定长度的间隔基团连接到腺苷时，可以有效抑制聚（ADP-核糖）聚合酶-1（PARP-1）。在异吲哚啉酮和腺苷核心结构之间引入哌嗪和琥珀酰连接基可产生强效化合物8a和10b，其IC（50）值分别为45和100 nM。