1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea | 1187213-95-1

分子结构分类

有机化合物 - 有机氧化合物

中文名称

——

中文别名

——

英文名称

1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

英文别名

1-Cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea；1-cyclopropyl-3-[3-fluoro-4-[2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]urea

1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea化学式

CAS

1187213-95-1

化学式

C₂₃H₁₇FN₄O₃S

mdl

——

分子量

448.477

InChiKey

WWMVLLXKSKIOIS-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

3.2
重原子数：

32
可旋转键数：

6
环数：

5.0
sp3杂化的碳原子比例：

0.13
拓扑面积：

121
氢给体数：

2
氢受体数：

7

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	1-(4-(2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorotphenyl)-3-cyclopropylurea	1187213-47-3	C₂₆H₂₃FN₄O₄S	506.557
——	4-(2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline	1123838-11-8	C₂₂H₁₈FN₃O₃S	423.468
——	2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine	1123838-08-3	C₂₂H₁₆FN₃O₅S	453.451
——	2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)-7-chlorothieno[3,2-b]pyridine	1123838-05-0	C₁₆H₁₃ClN₂O₂S	332.81

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea	1187212-75-4	C₂₇H₂₈FN₅O₃S	521.615
——	1-(4-(2-(5-5,8,11,14-tetraoxa-2-azapentadecylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1187212-69-6	C₃₂H₃₈FN₅O₆S	639.748
——	4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)butanoic acid	1187212-73-2	C₂₇H₂₆FN₅O₄S	535.599
——	1-(4-(2-(5-((1,4,7,10,13-pentaoxa-16-azacyclooctadecan-16-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1429339-93-4	C₃₅H₄₂FN₅O₇S	695.812
——	(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1429397-34-1	C₂₈H₂₉FN₆O₂S	532.642
——	(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxypropyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1429397-14-7	C₃₀H₃₃FN₆O₃S	576.695
——	1-(4-(2-(5-((3-(2.5.8.11-tetraoxatridecan-13-yloxy)azetidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1429340-23-7	C₃₅H₄₂FN₅O₇S	695.812
——	(S)-2-amino-6-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)hexanoic acid	1187212-70-9	C₂₉H₃₁FN₆O₄S	578.667
——	1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-(methylamino)acetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1429397-13-6	C₃₀H₃₂FN₇O₃S	589.694
——	1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea	1429397-32-9	C₂₉H₂₈ClFN₆O₃S	595.097
——	1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1341216-03-2	C₂₉H₂₉FN₆O₄S	576.651
——	1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-mercaptoacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1429397-24-9	C₂₉H₂₉FN₆O₃S₂	592.718
——	1-cyclopropyl-3-(3-fluoro-4-(2-(5-((2-oxopyrrolidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea	1187212-74-3	C₂₇H₂₄FN₅O₃S	517.584
——	1-(4-(2-(5-((4-(2,5,8,11-tetraoxatridecan-13-yl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1429339-92-3	C₃₆H₄₅FN₆O₆S	708.854
——	(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1429397-26-1	C₃₀H₃₃FN₆O₃S	576.695
——	1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-methoxyacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea	1429397-16-9	C₃₀H₃₁FN₆O₄S	590.678
——	3-cyclopropyl-N-(4-(2-(5-((4-(2-((2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl)disulfanyl)acetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea	1429397-25-0	C₅₈H₅₆F₂N₁₂O₆S₄	1183.42
——	1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1429340-09-9	C₃₈H₄₂FN₅O₇S	731.845
——	(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide	1187212-76-5	C₂₉H₃₀FN₅O₄S	563.653
——	1-(4-(2-(5-((4-(2,5,8,11-tetraoxatridecan-13-ylamino)piperidin-1-yl)methyl)pyridin-2-yl)thieno[3.2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1429340-02-2	C₃₇H₄₇FN₆O₆S	722.881
——	1-(4-(2-(5-((4-2,5,8,11-tetraoxatetradecanepiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea	1429340-14-6	C₃₇H₄₅FN₆O₇S	736.865
——	S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate	1429397-11-4	C₃₁H₃₁FN₆O₄S₂	634.755
——	tert-butyl (1-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)carbamate	1342836-98-9	C₃₃H₃₇FN₆O₄S	632.759
——	2-(2-(2-methoxyethoxy)ethoxy)ethyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate	1429340-18-0	C₃₅H₄₁FN₆O₇S	708.811
——	2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl dihydrogen phosphate	1429339-91-2	C₂₉H₃₀FN₆O₇PS	656.631
——	2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl hydrogen sulfate	1429340-26-0	C₂₉H₂₉FN₆O₇S₂	656.716
——	2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl butyrate	1429397-22-7	C₃₃H₃₅FN₆O₅S	646.743
——	tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate	1342837-57-3	C₃₃H₃₇FN₆O₄S	632.759
——	(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea	1429397-35-2	C₃₆H₄₇FN₆O₃SSi	690.957
——	1-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidine-3-carboxylic acid	1429397-28-3	C₂₉H₂₈FN₅O₄S	561.637
——	N-(1-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-N-(2,5,8,11-tetraoxatridecan-13-yl)acetamide	1429340-24-8	C₃₉H₄₉FN₆O₇S	764.918
——	(R)-tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-methylpiperazine-1-carboxylate	1429397-33-0	C₃₃H₃₇FN₆O₄S	632.759
——	di-tert-butyl 2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl phosphate	1429340-27-1	C₃₇H₄₆FN₆