4-氯-2,6-二硝基苯酚 | 88-87-9

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物 - 酚及其卤化、磺化、硝化或亚硝化衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-氯-2,6-二硝基苯酚
• 英文名称: 4-chloro-2,6-dinitrophenol
• CAS: 88-87-9
• 化学式: C₆H₃ClN₂O₅
• mdl: MFCD00035746
• 分子量: 218.553
• InChiKey: KESYALTWUAFAAC-UHFFFAOYSA-N

物化性质

• 熔点：
  81°C
• 密度：
  1.7400

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2908999090

制备方法与用途

4-氯-2,6-二硝基苯酚用于作为研究用化合物。

反应信息

• 作为反应物：
  描述：

  4-氯-2,6-二硝基苯酚 生成 2,6-diamino-4-chloro-phenol
  参考文献：
  名称：

  DE256794

  摘要：

  公开号：
• 作为产物：
  描述：

  2,4-二氯-6-硝基苯酚 在 硝酸 作用下， 生成 4-氯-2,6-二硝基苯酚
  参考文献：
  名称：

  Petersen, Chemische Berichte, 1873, vol. 6, p. 370

  摘要：

  DOI：

文献信息

• A European Perspective on Depression in the Community: The DEPRES Study
  作者：Saena Arbabzadeh-Bouchez、Andre Tylee、Jean-Pierre Lépine

  DOI：10.1017/s1092852900017430

  日期：2002.2

  Depression is one of the most prevalent disorders in the general population, causing personal and social disability and impairment. Major studies assessing the diagnosis and management of depression have shown that it is often underdiagnosed and undertreated. A pan-European study aimed at assessing the extent and consequences of depression in six different countries is reported in this article. Different types of depressive profiles are analyzed and their respective management has been compared. The importance of improving diagnosis and treatment of depression is underlined. Appropriate management of depression depends on the recognition of depressive symptoms by patients, their possibility of seeking care, and the ability of the primary care physician to recognize the disorder and prescribe the appropriate medicines. Improvement in all of these fields is necessary.

  摘要抑郁症是普通人群中最常见的疾病之一，会造成个人和社会的残疾和损伤。对抑郁症的诊断和管理进行评估的主要研究表明，抑郁症往往诊断不足、治疗不力。本文报告了一项泛欧研究，旨在评估六个不同国家抑郁症的程度和后果。研究分析了不同类型的抑郁症，并对其各自的治疗方法进行了比较。文章强调了改进抑郁症诊断和治疗的重要性。抑郁症的适当治疗取决于患者对抑郁症状的认识、他们寻求治疗的可能性以及初级保健医生识别疾病和开具适当药物的能力。所有这些领域都需要改进。
• Selective Nitration of Aromatic Compounds with Bismuth Subnitrate and Thionyl Chloride
  作者：Hussni Muathen

  DOI：10.3390/80700593

  日期：——

  Bismuth subnitrate/thionyl chloride have been found to be an efficient combination of reagents for nitration of a wide range of aromatic compounds in dichloromethane. Phenols, in particular, were easily mononitrated and dinitrated with the reagents by controlling the stoichiometry,

  已发现碱式硝酸铋/亚硫酰氯是一种有效的试剂组合，可用于在二氯甲烷中硝化多种芳香族化合物。尤其是酚类，通过控制化学计量，很容易与试剂一起单硝化和二硝化，
• Nitrogen Oxides and Nitric Acid Enable the Sustainable Hydroxylation and Nitrohydroxylation of Benzenes under Visible Light Irradiation
  作者：Laura Elena Hofmann、Leonard Mach、Markus R. Heinrich

  DOI：10.1021/acs.joc.7b02333

  日期：2018.1.5

  A new type of waste recycling strategy is described in which nitrogen oxides or nitric acid are directly employed in photocatalyzed hydroxylations and nitrohydroxylations of benzenes. Through these transformations, otherwise costly denitrification can be combined with the synthesis of valuable compounds for various applications.

  描述了一种新型的废物回收策略，其中氮氧化物或硝酸直接用于苯的光催化羟基化和硝基羟基化。通过这些转变，可以将原本昂贵的反硝化与有价值的化合物的合成结合起来，以用于各种应用。
• Nitration of Aromatic Compounds by Zn(NO₃)₂ · 2N₂O₄and Its Charcoal‐Supported System
  作者：Nasser Iranpoor、Habib Firouzabadi、Reza Heydari、Morteza Shiri

  DOI：10.1081/scc-200048450

  日期：2005.1

  Abstract Zn(NO3)2 · N2O4 and its charcoal supported system were found to be efficient nitrating agents. Mononitration of aromatic compounds such as benzene, alkyl benzenes, halobenzenes, nitrobenzene, anisol, and the highly selective mono‐, di‐, and trinitration of phenol, and dinitraion of substituted phenols were also performed in the presence of these reagents.

  摘要 Zn(NO3)2·N2O4 及其炭载体体系被认为是有效的硝化剂。苯、烷基苯、卤代苯、硝基苯、苯甲醚等芳香族化合物的单硝化，以及苯酚的高选择性单硝化、二硝化和三硝化，以及取代酚的二硝化也在这些试剂的存在下进行。
• PEG-N₂O₄: An Efficient Nitrating Agent for the Selective Mono- and Dinitration of Phenols Under Mild Conditions
  作者：Mohammad Ali Zolfigol、Elaheh Madrakian、Ezat Ghaemi、Khodabakhsh Niknam

  DOI：10.1080/00397910802136706

  日期：2008.9.12

  was easily impregnated on polyethyleneglycol to give a stable reagent. The polyethyleneglycol-N2O4 (PEG-N2O4) system was used as an effective nitrating agent for the nitration of phenols. Mono- and dinitrophenols can be obtained via direct nitration of phenols in the presence of PEG-N2O4 at room temperature in moderate to high yields.

  摘要 N2O4 很容易浸渍在聚乙二醇上，得到稳定的试剂。聚乙二醇- （PEG- ）体系被用作苯酚硝化的有效硝化剂。单硝基苯酚和二硝基苯酚可以通过苯酚在 PEG- 存在下在室温下以中等至高产率直接硝化获得。