7-acetoxy-4',5-dihydroxygenistein

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-acetoxy-4',5-dihydroxygenistein
• 英文别名: [5-hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-7-yl] acetate
• 化学式: C₁₇H₁₂O₆
• 分子量: 312.279
• InChiKey: BBJCHWFLOBUOST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  染料木素 、 乙酸酐 在 吡啶 作用下， 反应 7.0h， 以87.2%的产率得到7,4'-二乙酰氧基-5-羟基异黄酮
  参考文献：
  名称：

  Synthesis and cytotoxic activity of genistein derivatives

  摘要：

  A series of genistein derivatives was prepared and tested in vitro against leukocythemia (HL-60), colorectal adenocarcinoma (HT-29), and human gastric adenocarcinoma (SGC-7901) cell lines. Among these derivatives, 4',5-di-n-octoxy-7-gem-difluoromethylenegenistein, 9f, had the strongest activity against HL-60, HT-29, and SGC-7901 cells.

  DOI：

  10.1007/s00044-009-9271-z

文献信息

• ISOFLAVONES FOR TREATING MUCOPOLYSACCHARIDOSES
  申请人：Grynkiewicz Grzegorz

  公开号：US20090062380A1

  公开（公告）日：2009-03-05

  The invention relates to the medical use of natural isoflavones and their semisynthetic derivatives or the pharmaceutically acceptable salts thereof for the therapeutic and/or prophylactic treatment of diseases, at the base of which lies an excessive production or storage of glycosaminoglycans, especially for treatment of mucopolysaccharidoses. The isoflavones and their semisynthetic derivatives are represented by formula (I), in which R 1 and R 2 are the same or different and are independently H or alkyl, alkenyl, aryl alkylaryl, alkylcarbonyl, arylcarbonyl or mono-, di- or oligosaccharide group, each of then optionally substituted by at least one acyl, alkyl, cycloalkyl, alkoxyalkyl, aryl, alkylaryl, carboxyl or cyano; and R 3 is H, acyl or alkyl.
• US8178609B2
  申请人：——

  公开号：US8178609B2

  公开（公告）日：2012-05-15