卡普氯铵 | 13254-33-6

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 卡普氯铵
• 中文别名: (3-甲氧羰基丙基)氯化三甲铵
• 英文名称: Carpronium chloride
• 英文别名: (4-methoxy-4-oxobutyl)-trimethylazanium;chloride
• CAS: 13254-33-6
• 化学式: C₈H₁₈NO₂*Cl
• 分子量: 195.689
• InChiKey: RZMKWKZIJJNSLQ-UHFFFAOYSA-M

物化性质

• 熔点：
  126°

计算性质

• 辛醇/水分配系数(LogP)：
  -2.35
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2923900090

制备方法与用途

概述

卡普氯铵的化学名称为(3-甲氧基羰基丙基)氯化三甲铵一水合物，又称放线菌胺、三甲铵丁酸酯或秃发新。

用途

卡普氯铵是一种新型生发剂，其主要作用机制包括毛细血管扩张和发根刺激。它能够有效防止各种类型的脱发，促进毛发生长，并治疗干性脂漏和寻常型白斑。

反应信息

• 作为反应物：
  描述：

  卡普氯铵 生成 γ-丁内酯 、 四甲基氯化铵
  参考文献：
  名称：

  Pyrolysis reaction of carpronium chloride and its structurally related compounds. 2—a mass spectrometric study of the lactonization mechanism

  摘要：

  AbstractThe mechanism of the pyrolysis reaction of carpronium chloride [(CH3)3N+(CH2)3COOCH3CI−] leading to γ‐butyrolactone and tetramethylammonium chloride was investigated by means of thermal analysis, pyrolysis gas chromatography mass spectrometry and field desorption mass spectrometry, using deuterium labelling. The results indicated that carpronium chloride pyrolysed to yield equimolar amounts of γ‐butyrolactone and tetramethylammonium chloride, methyl transfer occurred between N and O during the pyrolysis process. The mechanism is discussed on the basis of the experimental results, and with the aid of the theoretical results calculated by the CNDO/2 method. The mechanism presented is as follows. γ‐Butyrolactone is formed by the intramolecular migration of the π‐orbital of CO to the carbon adjacent to [(CH3)3N]+ via a 5‐membered ring transition state, accompanied by a bimolecular reaction between [(CH3)3N]+ and the CH3 of OCH3, resulting in the formation of tetramethylammonium chloride in an amount equimolar with γ‐butyrolactone.

  DOI：

  10.1002/oms.1210180402
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 钯 作用下， 生成 卡普氯铵
  参考文献：
  名称：

  Strack; Foersterling, Chemische Berichte, 1943, vol. 76, p. 15,18

  摘要：

  DOI：

文献信息

• Extracts of Isochrysis sp.
  申请人：Herrmann Martina

  公开号：US20100080761A1

  公开（公告）日：2010-04-01

  The present invention relates to extracts of Isochrysis sp., preferably Tahitian Isochrysis, its cosmetic, dermatological and/or therapeutic uses and compositions and cosmetic, dermatological or therapeutic products comprising such an extract of Isochrysis sp., preferably Tahitian Isochrysis.

  本发明涉及Isochrysissp.的提取物，优选为塔希提Isochrysis，及其在化妆品、皮肤病学和/或治疗学上的用途以及包含该Isochrysissp.提取物的化妆品、皮肤病学或治疗学产品，优选为塔希提Isochrysis。
• Cosmetic composition
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0897712A1

  公开（公告）日：1999-02-24

  This specification relates to a cosmetic composition containing art extract of Croton birmanicus as an effective ingredient, particularly, a hair-growing composition. The composition not only has excellent hair revitalizing actions such as an alopecia preventing effect and a hair generation accelerating effect, and a dandruff or itch inhibiting action, but also has a specific hair growth accelerating action through activation of hair dermal papilla cells or hair follicular epitheliocytes.

  本规范涉及一种含有Croton birmanicus艺术提取物作为有效成分的化妆品组合物，特别是生发组合物。该组合物不仅具有优异的头发再生作用，如防脱发效果和加速头发生成的效果，以及抑制头皮屑或瘙痒的作用，而且还通过激活毛囊真皮乳头细胞或毛囊上皮细胞具有特定的头发生长加速作用。
• Oil agent and lubricant agent, moisturizer and external preparation composition containing the same
  申请人：Takeda Kyoichi

  公开号：US20080200544A1

  公开（公告）日：2008-08-21

  The present invention provides an oil agent having water solubility and oil solubility, as well as suppressed stickiness when applied to skin to exhibit excellent feeling of use, and also provides a lubricating agent, a moisturizing agent and an external preparation containing said oil agent. The oil agent of the present invention comprises a dibasic acid ester compound of general formula I: wherein R 1 is an alkylene group having a carbon number of 2-4, which may be mono- or poly substituted, R 2 and R 3 are, independently of each other, an alkyl group having a carbon number of 1-4, which may be mono- or poly substituted, n and m are, independently of each other, an integer of 0-4 with m+n≧1 (provided that the cases wherein both of R 2 and R 3 are an ethyl group and both of n and m are 1 are excluded).

  本发明提供了一种具有水溶性和油溶性的油剂，当涂抹在皮肤上时，具有抑制粘性，展现出优秀的使用感受，同时提供了一种润滑剂、保湿剂和含有该油剂的外用制剂。本发明的油剂包括一种一般式I的二元酸酯化合物：其中R1是碳数为2-4的烷基基团，可以是单取代或多取代，R2和R3分别是碳数为1-4的烷基基团，可以是单取代或多取代，n和m分别是0-4的整数，满足m+n≥1（排除R2和R3均为乙基基团，n和m均为1的情况）。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• External preparation for skin diseases containing nitroimidazole
  申请人：——

  公开号：US20030092754A1

  公开（公告）日：2003-05-15

  An external preparation for skin disease which comprises a nitroimidazole derivative represented by the following formula (I): 1 wherein R 1 , R 3 and R 4 may be the same or different and represent a hydrogen atom, a nitro group, a lower alkyl group, a substituted lower alkyl group, a lower alkenyl group, or a substituted lower alkenyl group; and R 2 represents a hydrogen atom, a lower alkyl group, a substituted lower alkyl group and a lower alkenyl group or a substituted lower alkenyl group, provided that any one of R 1 , R 3 and R 4 is a nitro group.

  一种外用制剂，用于皮肤疾病，包括以下式(I)所代表的硝基咪唑衍生物：1其中R1、R3和R4可以相同也可以不同，并表示氢原子、硝基、低烷基、取代的低烷基、低烯基或取代的低烯基；R2表示氢原子、低烷基、取代的低烷基和低烯基或取代的低烯基，只要R1、R3和R4中的任何一个是硝基。