S -(+)-烯虫酯 | 65733-16-6

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: S -(+)-烯虫酯
• 中文别名: S-(+)-烯虫酯
• 英文名称: (S)-methoprene
• 英文别名: (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid isopropyl ester；S-(+)-11-methoxy-3,7,11-trimethyl-2E,4E-dodecadienoic acid isopropyl ester；isopropyl (2E,4E,7S)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate；S-methoprene；methoprene；propan-2-yl (2E,4E,7S)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
• CAS: 65733-16-6
• 化学式: C₁₉H₃₄O₃
• 分子量: 310.477
• InChiKey: NFGXHKASABOEEW-GYMWBFJFSA-N

物化性质

• 沸点：
  385.7±25.0 °C(Predicted)
• 密度：
  0.913±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：20mg/mL，乙醇：10mg/mL
• 碰撞截面：
  187 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H315,H319,H335
• 储存条件：
  室温、密闭保存，并保持干燥。

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: S-(+)-Methoprene
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: S-(+)-Methoprene
CAS number: 65733-16-6

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C19H34O3
Molecular weight: 310.5

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

甲氧丙烯是一种保幼激素类似物，可以阻止昆虫从蛹期转变为成虫，并因此被用作一种杀虫剂。

反应信息

• 作为反应物：
  描述：

  S -(+)-烯虫酯 在 硫酸 作用下， 以 正己烷 为溶剂， 反应 336.0h， 以94%的产率得到isopropyl (2E,4E)-3,7,11-trimethyl-2,4,10-dodecatrienoate
  参考文献：
  名称：

  Synthesis of radioiodinated juvenile hormone analogs

  摘要：

  DOI：

  10.1021/jo00376a083
• 作为产物：
  描述：

  (S)-7-methoxy-3,7-dimethyloctyl acetate 在 氢氧化钾 、 4-hydroxy-TEMPO benzoate 、 碳酸氢钠 、 四正辛基溴化铵 、 sodium bromide 作用下， 以 甲醇 、 二氯甲烷 、 水 、 苯 为溶剂， 反应 4.5h， 生成 S -(+)-烯虫酯
  参考文献：
  名称：

  Gamalevich; Zhdankina; Kryshtal', Russian Journal of Organic Chemistry, 1997, vol. 33, # 4, p. 467 - 474

  摘要：

  DOI：

文献信息

• FORMULATIONS FOR THE DELIVERY OF ACTIVE AGENTS TO INSECTS, PLANTS, AND PLANT PATHOGENS
  申请人：Preceres Inc.

  公开号：US20170325457A1

  公开（公告）日：2017-11-16

  The present disclosure is directed to formulations comprising (1) at least one formulation transport agent, (2) at least one complexing agent, and (3) at least one active agent that modulates one or more traits of a target insect, plant, or plant pathogen. The present disclosure is also directed to methods of delivering such formulations to the target organism, as well as to formulation transport agents used to prepare such formulations.

  本公开涉及包含（1）至少一种制剂运输剂、（2）至少一种络合剂和（3）至少一种调节目标昆虫、植物或植物病原体的一个或多个特征的活性剂的配方。本公开还涉及将这种配方传递给目标生物体的方法，以及用于制备这种配方的制剂运输剂。
• 一种保幼激素类似物的制备方法
  申请人：常州胜杰化工有限公司

  公开号：CN104276946B

  公开（公告）日：2016-10-26

  本发明涉及杀虫剂领域，尤其涉及一种保幼激素类似物(包含S‑烯虫酯和S‑烯虫乙酯)的制备方法。本发明一种保幼激素类似物的制备方法，包括下列步骤：A.向反应容器内,加入原料(2E,4E)‑11‑R‑3,7,11‑三甲基‑2,4‑十二碳二烯酸(R为氢或甲氧基)，有机碱催化剂,以及有机溶剂，开启搅拌；B.滴加焦碳酸酯的有机溶剂(与步骤A有机溶剂相同)溶液；C.滴加完毕，0～30℃反应0～3h；D.加入水中止反应，反应液分相，分出有机相；E.减压浓缩，蒸馏得到产品。所述步骤也可以在焦碳酸酯和有机强碱催化剂互换加入顺序的条件下进行。本发明，反应条件温和，产品纯度高，收率高，发明路线绿色，安全，环保，工业化前景好。
• Pyrazolopyrimidines
  申请人：Bayer CropScience LP

  公开号：US07629294B2

  公开（公告）日：2009-12-08

  The invention relates to prazolopyrimidines of the formula in which R1, R2, R3, R4, R5, and X are as defined in the disclosure, to a process for preparing these compounds, and to their use for controlling unwanted microorganisms.

  本发明涉及式中的prazolopyrimidines，其中R1、R2、R3、R4、R5和X如本说明书中所定义的那样，以及制备这些化合物的过程，并将其用于控制不需要的微生物。
• Organic compound having cyano group and insecticides/miticides
  申请人：Nippon Soda Co., Ltd.

  公开号：US06987112B2

  公开（公告）日：2006-01-17

  The present invention is directed to compounds represented by Formula (1); wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions characterized by comprising one or more of said compounds and/or said salts as the active ingredients.

  本发明涉及由式（1）表示的化合物；其中A，R，X，Y和n如描述中所定义，其盐，以及含有一种或多种所述化合物和/或所述盐作为活性成分的杀虫剂/杀螨剂组合物。
• Highly Enantioselective Construction of Multifunctional Silicon‐Stereogenic Silacycles by Asymmetric Enamine Catalysis
  作者：Xue‐Xin Zhang、Yang Gao、Yan‐Xue Zhang、Jian Zhou、Jin‐Sheng Yu

  DOI：10.1002/anie.202217724

  日期：2023.2.20

  The enantioselective construction of silicon-stereocenter by asymmetric enamine catalysis is reported. The reaction proceeds via an unprecedented desymmetric intramolecular aldolization of prochiral siladials for the diverse synthesis of multifunctional silicon-stereogenic silacycles.

  报道了通过不对称烯胺催化对映选择性构建硅立体中心。该反应通过前手性 siladials 前所未有的不对称分子内醛缩化反应进行，用于多功能硅-立体硅环的多样化合成。