Galactose 1-phosphate Potassium salt | 19046-60-7

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Galactose 1-phosphate Potassium salt
• 英文别名: dipotassium;[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate
• CAS: 19046-60-7
• 化学式: C6H11K2O9P
• 分子量: 336.32
• InChiKey: KCIDZIIHRGYJAE-YGFYJFDDSA-L

物化性质

• 溶解度：
  H2O：50 mg/mL，澄清，无色
• 碰撞截面：
  148.2 Ų [M-H]-; 158.3 Ų [M+K]+; 157.5 Ų [M+Na]+

计算性质

• 辛醇/水分配系数(LogP)：
  -10.36
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  163
• 氢给体数：
  4
• 氢受体数：
  9

制备方法与用途

生物活性的 Galactose 1-phosphate Potassium Salt 是半乳糖代谢过程中的中间体，同时也是核苷酸糖的重要组成部分。

反应信息

• 作为反应物：
  描述：

  Galactose 1-phosphate Potassium salt 、 水 、 trioctylammonium 、 三辛胺 、 N,N'-二环己基-4-吗啉甲脒-5'-O-[羟基(4-吗啉基)磷酰]尿苷(1:1) 、 四氮唑 在 丙烯酰胺 、 NH4HCO3 、 氢气 、 methanol+acetone 、 异丙醇 作用下， 以 吡啶 为溶剂， 以gave 34 (134 mg, 91%) as a white solid after lyophilization (Rf 0.40, 2:1 i-PrOH/1M NH4OAc)的产率得到尿苷 5’-二二氧磷基半乳糖二钠盐
  参考文献：
  名称：

  Process for preparing nucleotide inhibitors of glycosyltransferases

  摘要：

  核苷酸连接的2-脱氧-2-氟糖苷被用作糖基转移酶的有效竞争性抑制剂。更具体地说，尿苷-5'-二磷酸-2-脱氧-2-氟半乳糖（UDP-2F-Gal）、鸟苷-5'-二磷酸-2-脱氧-2-氟-L-岩藻糖（GDP-2F-Fuc）、尿苷-51-二磷酸-2-脱氧-2-氟-D-葡萄糖（UDP-2F-Glu）、鸟苷-5'-二磷酸-2-脱氧-2-氟-D-甘露糖（GDP-2F-Man）、胞嘧啶-5'-单磷酸-2-脱氧-2-氟-D-唾液酸酸和胞嘧啶-5'-单磷酸-2-脱氧-2-KDO可以作为β-1,4-半乳糖转移酶、α-1,3-岩藻糖转移酶、葡糖转移酶、N-乙酰氨基葡萄糖转移酶、α-甘露糖转移酶、α-唾液酸转移酶和KDO转移酶的抑制剂。核苷酸连接的2-脱氧-2-氟糖苷的合成可使用化学酶法或化学方法实现。

  公开号：

  US05770407A1

文献信息

• DETECTION AND QUANTIFICATION OF ANALYTES BASED ON SIGNAL INDUCED BY ALKALINE PHOSPHATE
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20150024415A1

  公开（公告）日：2015-01-22

  A general methodology for highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method and sensors take advantage of the ability of alkaline phosphatase (ALP) to convert glucose-1-phosphate to glucose, and the ability of PGMs to detect the generated glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents, for example to diagnose disease, are also provided.
• US5770407A
  申请人：——

  公开号：US5770407A

  公开（公告）日：1998-06-23
• [EN] INHIBITORS OF GLYCOSYLTRANSFERASES<br/>[FR] INHIBITEURS DES GLYCOSYLTRANSFERASES
  申请人：——

  公开号：WO1998025940A1

  公开（公告）日：1998-06-18

  [EN] Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5'-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5'-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-Fuc), uridine-5'-diphospho-2-deoxy-2-fluoro-D-glucose (UDP-2F-Glu), guanosine-5'-diphospho-2-deoxy-2-fluoro-D-mannose (GDP-2F-Man), cytosine-5'-monophospho-2-deoxy-2-fluoro-D-sialic acid, and cytosine-5'-monophospho-2-deoxy-2-KDO may be employed as inhibitors of beta -1,4-galactosyltransferase, alpha -1,3-fucosyltransferase, glucosyltransferases, N-acetylglucosaminyltransferases, alpha -mannosyltransferases, alpha -sialyltransferases, and KDO-transferases, respectively. Synthesis of nucleotide-linked-2-deoxy-2-fluoroglycosides is achieved using either chemoenzymatic or chemical methodologies.
  [FR] L'invention porte sur des 2-désoxy-2-fluoroglycosides à liaison nucléotidique, utilisés comme puissants inhibiteurs compétitifs des glycosyltransférases. Elle porte en particulier sur l'uridine-5'-diphospho-2-désoxy-2-fluoro-galactose (UDP-2F-Gal), le guanidine-5'-diphospho-2-désoxy-2-fluoro-L-fucose (GDP-2F-Fuc), l'uridine-5'-diphospho-2-désoxy-2-fluoro-D-glucose (UDP-2F-Glu), le guanosine-5'-diphospho-2-désoxy-2-fluoro-D-mannose (GDP-2F-Man), l'acide cytosine-5'-monophospho-2-désoxy-2-fluoro-D-sialic, et le cytosine-5'-monophospho-2-déoxy-2-KDO qui peuvent être employés respectivement comme inhibiteurs de la beta -1,4-galactosyltransférase, de la alpha -1,3-fucosyltransférase, des glucosyltransférases, des N-acétylglucosaminyltransférases, des alpha -mannosyltransférases, des alpha -sialyltransférases, et des KDO-transférases. La synthèse des 2-désoxy-2-fluoroglycosides à liaison nucléotidique se fait selon des méthodologies de type chimioenzymatique, ou chimique.
• Process for preparing nucleotide inhibitors of glycosyltransferases
  申请人：The Scripps Research Institute

  公开号：US05770407A1

  公开（公告）日：1998-06-23

  Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5'-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5'-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-Fuc), uridine-51-diphospho-2-deoxy-2-fluoro-D-glucose (UDP-2F-Glu), guanosine-5'-diphospho-2-deoxy-2-fluoro-D-mannose (GDP-2F-Man), cytosine-5'-monophospho-2-deoxy-2-fluoro-D-sialic acid, and cytosine-5'-monophospho-2-deoxy-2-KDO may be employed as inhibitors of .beta.-1,4-galactosyltransferase, .alpha.-1,3-fucosyltransferase, glucosyltransferases, N-acetylglucosaminyltransferases, (.alpha.-mannosyltransferases, .alpha.-sialyltransferases, and KDO-transferases, respectively. Synthesis of nucleotide-linked-2-deoxy-2-fluoroglycosides is achieved using either chemoenzymatic or chemical methodologies.

  核苷酸连接的2-脱氧-2-氟糖苷被用作糖基转移酶的有效竞争性抑制剂。更具体地说，尿苷-5'-二磷酸-2-脱氧-2-氟半乳糖（UDP-2F-Gal）、鸟苷-5'-二磷酸-2-脱氧-2-氟-L-岩藻糖（GDP-2F-Fuc）、尿苷-51-二磷酸-2-脱氧-2-氟-D-葡萄糖（UDP-2F-Glu）、鸟苷-5'-二磷酸-2-脱氧-2-氟-D-甘露糖（GDP-2F-Man）、胞嘧啶-5'-单磷酸-2-脱氧-2-氟-D-唾液酸酸和胞嘧啶-5'-单磷酸-2-脱氧-2-KDO可以作为β-1,4-半乳糖转移酶、α-1,3-岩藻糖转移酶、葡糖转移酶、N-乙酰氨基葡萄糖转移酶、α-甘露糖转移酶、α-唾液酸转移酶和KDO转移酶的抑制剂。核苷酸连接的2-脱氧-2-氟糖苷的合成可使用化学酶法或化学方法实现。