trioctylammonium | 30734-02-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trioctylammonium
• 英文别名: tri-n-octylammonium；trioctylazanium
• CAS: 30734-02-2
• 化学式: C₂₄H₅₂N
• 分子量: 354.684
• InChiKey: XTAZYLNFDRKIHJ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  25
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  4.4
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  Galactose 1-phosphate Potassium salt 、 水 、 trioctylammonium 、 三辛胺 、 N,N'-二环己基-4-吗啉甲脒-5'-O-[羟基(4-吗啉基)磷酰]尿苷(1:1) 、 四氮唑 在 丙烯酰胺 、 NH4HCO3 、 氢气 、 methanol+acetone 、 异丙醇 作用下， 以 吡啶 为溶剂， 以gave 34 (134 mg, 91%) as a white solid after lyophilization (Rf 0.40, 2:1 i-PrOH/1M NH4OAc)的产率得到尿苷 5’-二二氧磷基半乳糖二钠盐
  参考文献：
  名称：

  Process for preparing nucleotide inhibitors of glycosyltransferases

  摘要：

  核苷酸连接的2-脱氧-2-氟糖苷被用作糖基转移酶的有效竞争性抑制剂。更具体地说，尿苷-5'-二磷酸-2-脱氧-2-氟半乳糖（UDP-2F-Gal）、鸟苷-5'-二磷酸-2-脱氧-2-氟-L-岩藻糖（GDP-2F-Fuc）、尿苷-51-二磷酸-2-脱氧-2-氟-D-葡萄糖（UDP-2F-Glu）、鸟苷-5'-二磷酸-2-脱氧-2-氟-D-甘露糖（GDP-2F-Man）、胞嘧啶-5'-单磷酸-2-脱氧-2-氟-D-唾液酸酸和胞嘧啶-5'-单磷酸-2-脱氧-2-KDO可以作为β-1,4-半乳糖转移酶、α-1,3-岩藻糖转移酶、葡糖转移酶、N-乙酰氨基葡萄糖转移酶、α-甘露糖转移酶、α-唾液酸转移酶和KDO转移酶的抑制剂。核苷酸连接的2-脱氧-2-氟糖苷的合成可使用化学酶法或化学方法实现。

  公开号：

  US05770407A1
• 作为产物：
  描述：

  2-甲基-2-羟基丙酸 、 三辛胺 以This initial weight results in a stoichiometric ratio of TOA/2-hydroxyisobutyric acid of 2.64的产率得到TOA 2-hydroxyisobutyric acid
  参考文献：
  名称：

  METHOD FOR THE PRODUCTION OF FREE CARBOXYLIC ACIDS

  摘要：

  一种制备自由羧酸的过程，包括：A）在水介质中加入式(I)的胺，其中R1、R2和R3分别独立相同或不同，支链或直链，可选择性取代的碳氢基团或H，通过生物细胞制备羧酸；B）对于添加的胺A）是水溶性的情况，加入式(I)的水不溶性胺，其中在A）或B）中，得到多相体系，并从水不溶性胺和羧酸形成相应的铵羧酸盐；C）去除水不溶性相；和D）加热水不溶性相，释放自由羧酸。

  公开号：

  US20110189742A1

文献信息

• BHQ-CAGED NUCLEOTIDE PROBES PHOTOLYSABLE BY TWO-PHOTON EXCITATION
  申请人：Dore Timothy M.

  公开号：US20100048502A1

  公开（公告）日：2010-02-25

  The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by formula (I) that may be activated by two-photon excitation, and methods of synthesis of such compounds. 8-Bromo-7-hydroxyquinoline-caged ATP was synthesized and examined for its photochemistry as a biologically useful, temporally and spatially controlled ATP-releasing reagent. The combination of two-photon excitation hydrolysis and activation of caged ATP enables methods for finely focusing ATP activation at the sub-cellular level or to a greater depth of activation, thereby providing improved resolution of ATP-dependent processes at the cellular level.

  该披露涵盖了如caged核苷酸磷酸酯（caged nucleotides）之类的caged化合物。在一种实施例中，caged核苷酸包括与公式（I）所描述的相应化合物，可以通过双光子激发激活，以及这些化合物的合成方法。8-溴-7-羟基喹啉caged ATP被合成并检查其光化学性质作为一种生物学上有用的、时间和空间可控的ATP释放试剂。双光子激发水解和激活caged ATP的组合使得在亚细胞水平或更大深度的ATP激活方法得以精细聚焦，从而提供了更好的细胞水平上ATP依赖过程的分辨率。
• BHQ-caged nucleotide probes photolysable by two-photon excitation
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US08173620B2

  公开（公告）日：2012-05-08

  The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by formula (I) that may be activated by two-photon excitation, and methods of synthesis of such compounds. 8-Bromo-7-hydroxyquinoline-caged ATP was synthesized and examined for its photochemistry as a biologically useful, temporally and spatially controlled ATP-releasing reagent. The combination of two-photon excitation hydrolysis and activation of caged ATP enables methods for finely focusing ATP activation at the sub-cellular level or to a greater depth of activation, thereby providing improved resolution of ATP-dependent processes at the cellular level.

  该披露涵盖了笼状化合物，例如笼状核苷酸磷酸酯（笼状核苷酸）。在一种实施方式中，笼状核苷酸包括与式（I）所描述的化合物相对应的化合物，可以通过双光子激发激活，并且还涉及这些化合物的合成方法。8-溴-7-羟基喹啉笼状ATP已被合成并检查其光化学作用作为一种生物学上有用的、时间和空间可控的ATP释放试剂。双光子激发水解和激活笼状ATP的组合使得在亚细胞水平或更大深度的ATP激活方法得到了精细聚焦，从而提供了在细胞水平上改进ATP依赖过程的分辨率的方法。
• Method for the production of free carboxylic acids
  申请人：Haas Thomas

  公开号：US08703451B2

  公开（公告）日：2014-04-22

  A process for the preparation of free carboxylic acids including: A) preparation of carboxylic acid by a biological cell located in an aqueous medium with addition of an amine of formula (I) where R1, R2 and R3, independently of one another, are identical or different, branched or unbranched, optionally substituted hydrocarbon radicals or H; B) for cases where the added amine A) is water-soluble, addition of a water-insoluble amine of formula (I), where, in A) or B), a multiphase system is obtained and the corresponding ammonium carboxylate is formed from the water-insoluble amine and the carboxylic acid; C) removal of the water-insoluble phase; and D) heating of the water-insoluble phase with release of free carboxylic acid.

  一种制备自由羧酸的方法，包括：A）通过位于水介质中的生物细胞，加入式（I）的胺来制备羧酸，其中R1、R2和R3独立地相同或不同，支链或直链，可选择性地取代烃基或H；B）对于添加的胺A）为水溶性的情况，加入式（I）的不溶于水的胺，在A）或B）中，获得多相系统，并从不溶于水的胺和羧酸形成相应的铵羧酸盐；C）去除不溶于水的相；和D）加热不溶于水的相，释放自由羧酸。
• Process for preparing nucleotide inhibitors of glycosyltransferases
  申请人：The Scripps Research Institute

  公开号：US05770407A1

  公开（公告）日：1998-06-23

  Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5'-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5'-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-Fuc), uridine-51-diphospho-2-deoxy-2-fluoro-D-glucose (UDP-2F-Glu), guanosine-5'-diphospho-2-deoxy-2-fluoro-D-mannose (GDP-2F-Man), cytosine-5'-monophospho-2-deoxy-2-fluoro-D-sialic acid, and cytosine-5'-monophospho-2-deoxy-2-KDO may be employed as inhibitors of .beta.-1,4-galactosyltransferase, .alpha.-1,3-fucosyltransferase, glucosyltransferases, N-acetylglucosaminyltransferases, (.alpha.-mannosyltransferases, .alpha.-sialyltransferases, and KDO-transferases, respectively. Synthesis of nucleotide-linked-2-deoxy-2-fluoroglycosides is achieved using either chemoenzymatic or chemical methodologies.

  核苷酸连接的2-脱氧-2-氟糖苷被用作糖基转移酶的有效竞争性抑制剂。更具体地说，尿苷-5'-二磷酸-2-脱氧-2-氟半乳糖（UDP-2F-Gal）、鸟苷-5'-二磷酸-2-脱氧-2-氟-L-岩藻糖（GDP-2F-Fuc）、尿苷-51-二磷酸-2-脱氧-2-氟-D-葡萄糖（UDP-2F-Glu）、鸟苷-5'-二磷酸-2-脱氧-2-氟-D-甘露糖（GDP-2F-Man）、胞嘧啶-5'-单磷酸-2-脱氧-2-氟-D-唾液酸酸和胞嘧啶-5'-单磷酸-2-脱氧-2-KDO可以作为β-1,4-半乳糖转移酶、α-1,3-岩藻糖转移酶、葡糖转移酶、N-乙酰氨基葡萄糖转移酶、α-甘露糖转移酶、α-唾液酸转移酶和KDO转移酶的抑制剂。核苷酸连接的2-脱氧-2-氟糖苷的合成可使用化学酶法或化学方法实现。
• METHOD FOR THE PRODUCTION OF FREE CARBOXYLIC ACIDS
  申请人：Haas Thomas

  公开号：US20110189742A1

  公开（公告）日：2011-08-04

  A process for the preparation of free carboxylic acids including: A) preparation of carboxylic acid by a biological cell located in an aqueous medium with addition of an amine of formula (I) where R 1 , R 2 and R 3 , independently of one another, are identical or different, branched or unbranched, optionally substituted hydrocarbon radicals or H; B) for cases where the added amine A) is water-soluble, addition of a water-insoluble amine of formula (I), where, in A) or B), a multiphase system is obtained and the corresponding ammonium carboxylate is formed from the water-insoluble amine and the carboxylic acid; C) removal of the water-insoluble phase; and D) heating of the water-insoluble phase with release of free carboxylic acid.

  一种制备自由羧酸的过程，包括：A）在水介质中加入式(I)的胺，其中R1、R2和R3分别独立相同或不同，支链或直链，可选择性取代的碳氢基团或H，通过生物细胞制备羧酸；B）对于添加的胺A）是水溶性的情况，加入式(I)的水不溶性胺，其中在A）或B）中，得到多相体系，并从水不溶性胺和羧酸形成相应的铵羧酸盐；C）去除水不溶性相；和D）加热水不溶性相，释放自由羧酸。