Copper D-gluconate | 13005-35-1

• 物质功能分类: 有机原料 - 有机金属盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Copper D-gluconate
• 英文别名: copper;2,3,4,5,6-pentahydroxyhexanoate
• CAS: 13005-35-1
• 化学式: C12H22CuO14
• 分子量: 453.84
• InChiKey: OCUCCJIRFHNWBP-UHFFFAOYSA-L

物化性质

• 熔点：
  156°C

计算性质

• 辛醇/水分配系数(LogP)：
  -9.66
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  283
• 氢给体数：
  10
• 氢受体数：
  14

安全信息

• 海关编码：
  2918199090

SDS

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Section 1: Product Identification
Chemical Name: Copper (II) gluconate, min. 98%
CAS Registry Number: 13005-35-1
Formula: Cu[OOC(CHOH)4CH2OH]2
EINECS Number: none
Chemical Family: salt of an organic acid
Synonym: Gluconic acid, copper (+2) salt

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 13005-35-1 100% 1mg/m3 (as Cu) 1mg/m3 (as Cu)

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Section 3: Hazards Identification
Emergency Overview: Irritating to the skin, eyes and respiratory tract.
Primary Routes of Exposure: Ingestion, inhalation
Eye Contact: Causes slight to mild irritation of the eyes
Skin Contact: Causes slight to mild irritation of the skin.
Inhalation: The material is a fine powder. Irritating to the nose, mucous membranes and respiratory tract.
Ingestion: Ingestion of copper compounds may lead to vomiting, exhaustion, anemia, convulsions and coma.
Acute Health Affects: Irritating to skin, eyes and respiratory tract.
Chronic Health Affects: No information available on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: none
Explosion Limits: none
Extinguishing Medium: carbon dioxide, foam or dry powder
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit irritating fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Spill and Leak Procedures: Small spills can be mixed with vermiculite or sodium carbonate and swept up.

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SECTION 7: Handling and Storage
Handling and Storage: Store in a tightly sealed container. Handle the material in a ventilated area.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: blue pwdr.
Molecular Weight: 453.85
Melting Point: no data
Boiling Point: no data
Vapor Pressure: not applicable
Specific Gravity: 1.831
Odor: none
Solubility in Water: slightly soluble

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SECTION 10: Stability and Reactivity
Stability: air and moisture stable solid
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: none
Incompatibility: Oxidizing agents
Decomposition Products: carbon dioxide, carbon monoxide, organic fumes, and copper salts.

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SECTION 11: Toxicological Information
RTECS Data: No specific information available on this product.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

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SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory.
SARA (Title 313): See Category Code N100 for reporting.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质

葡萄糖酸铜是一种浅蓝色结晶或粉末，无臭味。其熔点为155~157℃，极易溶于水，但难溶于乙醇。根据哈尔滨医科大学的研究，小白鼠经口LD₅₀值为0.419 g/kg。

用途

葡萄糖酸铜是一种优良的营养强化剂，在我国被允许用于婴幼儿配方食品中，推荐使用量为7.5～10 mg/kg（以铜计）。此外，在乳制品中的最大添加量为5.7～7.5 mg/kg。

生产方法 发酵法

以葡萄糖为原料，通过黑霉菌发酵氧化生成葡萄糖酸，再与碳酸铜或碱式碳酸铜反应得到葡萄糖酸铜。此法设备复杂、浓缩能耗高且提纯结晶较为困难。

直接法

由葡萄糖酸钙与硫酸铜直接反应生成葡萄糖酸铜。虽然工艺简单，但残留的硫酸钙难以去除。

化学氧化法

以葡萄糖为原料，使用臭氧进行氧化得到葡萄糖酸，经减压浓缩和脱水后得葡萄糖酸内酯，再与碳酸铜反应生成葡萄糖酸铜。

酸化法

具体步骤如下：将1.2摩尔的葡萄糖酸钙加入等量的硫酸溶液中，在60～90℃下反应1～2小时。趁热过滤析出的硫酸钙沉淀后，得到无色或淡黄色的葡萄糖酸溶液（相对密度1.12～1.16）。随后向该溶液中滴加4克氢氧化钡水溶液和1.5克草酸水溶液，并搅拌反应15分钟以除去残留的Ca²⁺和SO₄²⁻。通过阴、阳离子交换树脂纯化后，得到无色透明的葡萄糖酸溶液。

接下来将1摩尔结晶硫酸铜溶液与2摩尔氢氧化钠溶液混合，在40～60℃下反应0.5～1小时，过滤并用水洗涤滤饼以获得黑色氧化铜结晶。随后分批加入上述葡萄糖酸溶液中进行反应，lh后过滤未反应物。冷却静置3～5小时后析出结晶。加入适量95%的乙醇，搅拌成糊状后再过滤，滤饼于50℃下真空干燥，最终得到成品，收率为90%～92.5%。

化学方程式如下： [ (C_6H_{11}O_7)2Ca + H_2SO_4 \rightarrow 2(C_6H{12}O_7) + CaSO_4↓ ] [ 2(C_6H_{12}O_7) + CuO \rightarrow (C_6H_{11}O_7)_2Cu + H_2O ]

文献信息

• Method for reducing acrylamide formation in thermally processed foods
  申请人：Elder Allen Vincent

  公开号：US20050064084A1

  公开（公告）日：2005-03-24

  A combination of two or more agents is added to a fabricated food prior to cooking in order to reduce the formation of acrylamide. The fabricated food product can be a corn chip or a potato chip. The agents can include any of a divalent or trivalent cation or combination of such cations, an acid, or an amino acid. The agents can be added during milling, dry mix, wet mix, or other admix, so that the agents are present throughout the food product. In preferred embodiments, calcium cations are used in conjunction with phosphoric acid, citric acid, and/or cysteine. The combination of agents can be adjusted in order to reduce the acrylamide formation in the finished product to a desired level while minimally affecting the quality and characteristics of the end product.

  在烹饪之前，向制造食品中添加两种或更多的剂以减少丙烯酰胺的形成。制造的食品产品可以是玉米片或土豆片。这些剂可以包括任何二价或三价阳离子或这些阳离子的组合，酸或氨基酸。这些剂可以在磨碎、干混、湿混或其他混合过程中添加，以使剂物质分布在整个食品产品中。在优选实施例中，钙阳离子与磷酸、柠檬酸和/或半胱氨酸一起使用。可以调整剂的组合，以使成品中丙烯酰胺的形成降至所需水平，同时最小程度地影响最终产品的质量和特性。
• Urea phosphite
  申请人：Dean William Frank

  公开号：US20060063675A1

  公开（公告）日：2006-03-23

  Urea Phosphite is a new composition of matter useful as a fertilizer and as a fungicide. It is made by reacting phosphorous acid with urea. Urea Phosphite is characterized by being a liquid produced in an unprocessed reaction, and by having phosphite as a phosphorus source and urea as a nitrogen source. The reaction products may be separated, blended with an admix and spray dried, or, dissolved in water.

  尿素亚磷酸盐是一种新的物质组成，可作为肥料和杀菌剂使用。它是通过将磷酸与尿素反应而制成的。尿素亚磷酸盐的特点是它是一种未经加工反应产生的液体，磷酸盐作为磷源，尿素作为氮源。反应产物可以分离，与混合剂混合并喷雾干燥，或溶于水中。
• Method and composition for promoting and controlling growth of plants
  申请人：——

  公开号：US20020121046A1

  公开（公告）日：2002-09-05

  Composition for and method of stimulating growth of plants, e.g. increase in crop production. The composition comprises a carbon skeleton/energy component, typically a sugar or mixture of sugars; a macronutrient component providing the elements nitrogen, phosphorus, potassium and calcium, preferably also magnesium and sulfur; a micronutrient component providing zinc, iron and manganese, preferably also copper, boron, molybdenum and cobalt. The composition also preferably contains a vitamin/cofactor component and an enhancement component. The composition may be in the form of an aqueous solution or in a form suitable for coating seeds or coating pollen. It may be applied as a foliar spray, as a soil amendment, as a root dip or as an injectable solution. Preferably where, for example, it is used as a foliar spray it is applied at intervals at different stages of growth. The method is useful for treating vegetation to promotes plant growth and/or crop production, also for treating pollen, seeds, roots and soil and inhibiting growth of insects and micro-organisms. A formulation including an energy/carbon skeleton component, a macro nutrient component and a micro nutrient component is applied,, e.g. in aqueous solution by foliar spraying. This is done in a manner to make optimum use of the inherent ability of vegetation to harvest solar energy and to utilize other sources of energy and carbon skeleton, such that the energy and nutrients applied by the method of the invention is a fraction of the energy and carbon skeleton requirements of the vegetation.

  一种用于刺激植物生长的组合物和方法，例如增加作物产量。该组合物包括碳骨架/能量成分，通常为糖或糖混合物；提供氮、磷、钾和钙元素的大量营养成分，最好还包括镁和硫；提供锌、铁和锰元素的微量营养成分，最好还包括铜、硼、钼和钴。该组合物还最好包含维生素/辅因子成分和增强成分。该组合物可以是水溶液形式或适合于涂覆种子或花粉的形式。它可以作为叶面喷雾、土壤改良剂、根部浸泡或注射溶液应用。最好在不同生长阶段的间隔时间内使用，例如作为叶面喷雾使用。该方法对于促进植物生长和/或作物产量非常有用，还用于处理花粉、种子、根和土壤，并抑制昆虫和微生物的生长。该方法应用包括能量/碳骨架成分、大量营养成分和微量营养成分的配方，例如通过叶面喷雾以水溶液形式应用。这样做是为了最大限度地利用植物收集太阳能的内在能力，并利用其他能源和碳骨架来源，使本发明方法应用的能量和营养成分是植物所需能量和碳骨架需求的一部分。
• AGROHORTICULTURAL BACTERICIDE
  申请人：OTSUKA KAGAKU KABUSHIKI KAISHA

  公开号：EP0713645A1

  公开（公告）日：1996-05-29

  A primary object of the present invention is to provide a highly safe germicidal composition for agricultural and horticultural use which show excellent germicidal activity not only against ordinary bacteria and fungi but also against chemical-resistant bacterial and fungal strains. The germicidal composition of the invention comprises an aldonic acid copper salt as an active ingredient.

  本发明的主要目的是提供一种用于农业和园艺的高度安全的杀菌组合物，它不仅对普通细菌和真菌，而且对耐化学腐蚀的细菌和真菌菌株都有极好的杀菌活性。本发明的杀菌组合物包括作为活性成分的醛酸铜盐。
• A process for preparing monomers
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0837049A1

  公开（公告）日：1998-04-22

  A process for preparing monomers useful in a wide range of polymers is disclosed.

  本发明公开了一种用于制备多种聚合物单体的工艺。