阿拉伯碳酸氢二钾 | 488-31-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 阿拉伯碳酸氢二钾
• 英文名称: L-Arabinaric acid
• 英文别名: D-Arabinaric acid；xylaric acid；2,3,4-trihydroxypentanedioic acid；2-(4-oxopyran-3-yl)acetic acid；D-xylo-trihydroxyglutaric acid；meso-xylaric acid；D-Xylonic acid；D-xylaric acid；xylo-2,3,4-trihydroxy-glutaric acid；xylo-2,3,4-Trihydroxy-glutarsaeure
• CAS: 488-31-3；608-54-8；608-55-9；6703-05-5；10158-64-2；20869-04-9；33012-62-3
• 化学式: C₅H₈O₇
• 分子量: 180.114
• InChiKey: NPTTZSYLTYJCPR-FFEAPLRNSA-N

物化性质

• 熔点：
  150-151 °C
• 沸点：
  685.0±55.0 °C(Predicted)
• 密度：
  1.916±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于酸性水溶液（轻微）、水（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.76
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  135.29
• 氢给体数：
  5.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  阿拉伯碳酸氢二钾 在 吡啶 、 乙酰氯 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 9.0h， 生成 2,3,4-tri-O-acetyl-N,N'-dimethylxylaramide
  参考文献：
  名称：

  Pentaric Acids and Derivatives from Nitric Acid–Oxidized Pentoses

  摘要：

  This report describes the preparation of the four stereoisomeric pentaric acids by nitric acid oxidation of d-xylose, d-arabinose, l-arabinose, and d-ribose, with xylaric, d-arabinaric, and l-arabinaric acids being made in a reactor under computer control. The pentaric acids were converted to their crystalline N,N-dimethylpentaramides, derivatives that proved useful for isolation of the arabinaric acids from their respective oxidation mixtures. The N,N-dimethylpentaramides were readily convertible to the corresponding pentaric acid disodium salts in aqueous sodium chloride. The 2,3,4-O-triacetyl-N,N-dimethylpentaramides of xylaric, l-arabinaric, and ribaric acid were also prepared. Ribaric acid was isolated as crystalline 1,4(5,2)-ribarolactone and further characterized by x-ray crystallography.

  DOI：

  10.1080/07328303.2012.745550
• 作为产物：
  描述：

  D-木糖 在 硝酸 作用下， 生成 阿拉伯碳酸氢二钾
  参考文献：
  名称：

  Ssytschew, Zhurnal Prikladnoi Khimii, 1938, vol. 11, p. 69

  摘要：

  DOI：

文献信息

• Oxidation of certain cyclic carbonyl compounds with alkaline hydrogen peroxide
  作者：Horace S. Isbell、Harriet L. Frush、Zlata Orhanovic

  DOI：10.1016/s0008-6215(00)83975-0

  日期：1975.8

  Abstract The following cyclic compounds were oxidized at 4° by means of aqueous sodium peroxide in large excess: 2,3,4,6/5-pentahydroxycyclohexanone ( 1 ); xylo -pentahydroxy-2-cyclohexen-l-one ( 2 ); xylo -trihydroxycyclohexane-1,2,3-trione ( 3 ); reductic acid ( 4 ); and ninhydrin ( 5 ). On oxidation, 1 , 2 , and 3 gave carbon dioxide, formic acid, and oxalic acid; in addition, 1 yielded DL -glucaric

  摘要下列环状化合物在过量4％的过氧化钠水溶液中被氧化：2,3,4,6 / 5-五羟基环己酮（1）; 二甲苯基-五羟基-2-环己烯-1-酮（2）; 二甲苯基-三羟基环己烷-1,2,3-三酮（3）; 还原酸（4）; 和茚三酮（5）。氧化时，1，2和3生成二氧化碳，甲酸和草酸。另外，1产生DL-葡糖二酸，2和3产生木糖酸。化合物4产生几乎等分子量的二氧化碳和琥珀酸。除了少量的甲酸外，化合物5分别以92％和95％的收率得到二氧化碳和邻苯二甲酸。提出了反应机理。
• Haemolysis due to active venous drainage during cardiopulmonary bypass: comparison of two different techniques
  作者：Silvia Cirri、Luca Negri、Marco Babbini、Giorgio Latis、Boutros Khlat、Giuseppe Tarelli、Paolo Panisi、Enzo Mazzaro、Alessandro Bellisario、Bruna Borghetti、Fernanda Bordignon、Mario Ferrara、Helga Pavan、Massimo Meco

  DOI：10.1177/026765910101600408

  日期：2001.7

  To facilitate mini-access for cardiac surgery, two different methods of active venous drainage are used: vacuum assisted drainage and centrifugal pump aspiration on the venous line. The aim of this study was to compare the haemolysis produced using these two techniques.

  From June to December 1999, 50 consecutive patients were operated on using a ministernotomy. All of these patients had valvular surgery for either valve repair or valve replacement (9 MVRepair, 11 MVR, 29 AVR, 1 AVR+MVR). They were randomized into two groups: Group A, 25 patients who underwent surgery where vacuum assisted drainage was used, and Group B, 25 patients where kinetic asssisted venous drainage with centrifugal pump venous aspiration was used. Patient characteristics of both groups were similar for age, gender, body weight, body surface area, height, cardiopulmonary bypass (CPB) time, aortic crossclamp time, priming volume, cardioplegia volume, haemoglobin concentration, haematocrit, serum creatinine, bilirubin, lactate dehydrogenase (LDH), serum glutamic oxaloacetic transaminase (sGOT), serum glutamic pyruvic transaminase (sGPT), aptoglobin, reticulocytes, and platelet count. We checked all these laboratory parameters preoperatively, at the end of CPB, and 2 and 24 h after operation. We also checked haemoglobinuria at these same time points. We assessed blood loss at 6, 12, and 24 h after the operation and calculated total postoperative bleeding. There was a tendency towards a greater increase in LDH, sGOT and sGPT in Group A more than in Group B, but these data did not reach statistical significance. Platelet count was always lower in Group A and aptoglobin increased in Group A more than in Group B. More patients in Group A had haemoglobinuria.

  These findings indicate that haemolysis is increased more in patients treated with vacuum assisted drainage, when compared to the rise in haemolysis in those treated with centrifugal pump venous drainage. Total bleeding is also greater in Group A.

  为了促进心脏手术的微创访问，使用了两种不同的主动静脉引流方法：真空辅助引流和离心泵吸引静脉线。本研究的目的是比较使用这两种技术产生的溶血现象。 从1999年6月到12月，连续50名患者接受了微胸骨切开手术。所有这些患者都接受了瓣膜手术，进行了瓣膜修复或瓣膜置换（9例二尖瓣修复，11例二尖瓣置换，29例主动脉瓣置换，1例主动脉瓣+二尖瓣置换）。他们被随机分为两组：A组，25名接受了使用真空辅助引流的手术的患者，和B组，25名接受了使用离心泵吸引静脉引流的动力学辅助引流的患者。两组患者的特征在年龄、性别、体重、体表面积、身高、体外循环（CPB）时间、主动脉阻断时间、灌注量、心肌保护液量、血红蛋白浓度、红细胞比容、血清肌酐、胆红素、乳酸脱氢酶（LDH）、血清谷草转氨酶（sGOT）、血清谷丙转氨酶（sGPT）、适配蛋白、网织红细胞和血小板计数方面相似。我们在术前、CPB结束时以及术后2小时和24小时检查了所有这些实验室参数。我们还在这些时间点检查了溶血尿。我们评估了术后6、12和24小时的出血量，并计算了总术后出血量。A组中LDH、sGOT和sGPT的增加趋势比B组更明显，但这些数据并未达到统计学意义。血小板计数在A组始终较低，适配蛋白在A组中的增加超过了B组。A组中有更多患者出现溶血尿。 这些发现表明，与使用离心泵静脉引流治疗的患者相比，使用真空辅助引流的患者溶血现象增加更多。总出血量在A组也更大。
• Aerobic Oxidation of Xylose to Xylaric Acid in Water over Pt Catalysts
  作者：Sunitha Sadula、Basudeb Saha

  DOI：10.1002/cssc.201800494

  日期：2018.7.11

  efficient and low temperature aerobic oxidation of xylose to xylaric acid, a promising bio‐based chemical for the production of glutaric acid, over commercial catalysts in water. Among several heterogeneous catalysts investigated, Pt/C exhibits the best activity. Systematic variation of reaction parameters in the pH range of 2.5 to 10 suggests that the reaction is fast at higher temperatures but high C−C

  将生物质中间体高效节能地催化转化为功能化学品可以使生物产品可行。在此，我们报告了在水中商业化的催化剂上，木糖被高效有效地高温氧化为木糖酸的木糖酸，这是一种有前途的生物基化学物质，用于生产戊二酸。在研究的几种非均相催化剂中，Pt / C表现出最好的活性。pH在2.5至10范围内的反应参数的系统变化表明，该反应在较高温度下反应较快，但中间C 5氧化产物向低碳羧酸的高C-C裂解会破坏木糖酸的选择性。在基本溶液中，CC裂解也很高。在中性pH和60°C下进行氧化可获得最高的木糖酸收率（64％）。Ø 2压力和Pt量对反应性有重要影响。短链羧酸的脱羧导致CO 2的形成，从而导致一些碳的损失。然而，在木糖存在下，这种脱羧作用是缓慢的。在五次循环后，就产物选择性而言，该催化剂保持了相当的活性，没有Pt浸出的迹象。
• Hydroxypolyamide Gel Forming Agents
  申请人：Kiely Donald E.

  公开号：US20090131259A1

  公开（公告）日：2009-05-21

  Hydroxypolyamides, hydroxypolyamide products, and post-hydroxypolyamides are disclosed as gel forming agents. Hydroxypolyamides and post-hydroxypolyamides are prepared from known methods. Hydroxypolyamide products are produced from a modified polymerization procedure which utilizes strong base for deprotonation of ammonium salts from the esterification of stoichiometrically equivalent polyacid:polyamine salts. The hydroxypolyamide products are capable of gel formation at lower concentrations than hydroxypolyamides and post-hydroxypolyamides from the known methods of preparation, and are therefore superior gel forming agents.

  氢氧基聚酰胺、氢氧基聚酰胺产品和后处理氢氧基聚酰胺被披露为凝胶形成剂。氢氧基聚酰胺和后处理氢氧基聚酰胺是从已知方法制备的。氢氧基聚酰胺产品是通过改进的聚合程序生产的，该程序利用强碱去质子化酯化的化学计量等量聚酸：聚胺盐。这些氢氧基聚酰胺产品能够在比已知制备方法中的氢氧基聚酰胺和后处理氢氧基聚酰胺更低的浓度下形成凝胶，因此是优越的凝胶形成剂。
• The Formation of Polyhydroxy-dialdehydes. I. Xylo-trihydroxy-glutaric Dialdehyde and its Derivatives
  作者：Koichi Iwadare

  DOI：10.1246/bcsj.16.40

  日期：1941.2

  By the oxidation of 1,2-monoacetone-d-glucofuranose with lead tetraacetate, 1,2-monoacetone-d-xylo-trihydroxy-glutaric dialdehyde was obtained, which distils at 132-136° at 0.01-0.02 mm. pressure, and has specific rotatory power, [α]D16, of 20°±3° in alcohol. Its monophenylhydrazone melts at 140.5–141° and has specific rotatory power, [α]D10, of −41°±1° in chloroform, and its monosemicarbazone melts

  通过用四乙酸铅氧化1,2-单丙酮-d-呋喃葡萄糖，得到1,2-单丙酮-d-木-三羟基-戊二醛，在0.01-0.02 mm处在132-136°蒸馏。压力，并在酒精中具有 20°±3° 的特定旋转力 [α]D16。其单苯腙在140.5-141°熔化，在氯仿中具有-41°±1°的比旋光度[α]D10，其单缩氨基脲在209.5°熔化。将1,2-单丙酮-d-木-三羟基-戊二醛水解为木-三羟基-戊二醛，得到后者的双苯腙和双对硝基苯腙。它们的熔点分别为126.5-127.5°和191-192°。1,2-单丙酮-d-木-三羟基-戊二醛和木-三羟基-戊二醛在碳酸锶存在下被溴氧化，锶1，