Lobeline sulfate | 134-64-5

• 物质功能分类: 天然产物 - 生物碱
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Lobeline sulfate
• 英文别名: 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;sulfuric acid
• CAS: 134-64-5
• 化学式: C44H56N2O8S
• 分子量: 773.0
• InChiKey: GRZMOSSVIPFGFF-GNJLJDPWSA-N

物化性质

• 熔点：
  152-154 °C
• 比旋光度：
  D20 -25° (c = 2)
• 密度：
  1.0400 (rough estimate)
• 溶解度：
  DMSO：100 mg/mL (129.37 mM)；乙醇：100 mg/mL (129.37 mM)

计算性质

• 辛醇/水分配系数(LogP)：
  7.82
• 重原子数：
  55
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  164
• 氢给体数：
  4
• 氢受体数：
  10

安全信息

• 危险等级：
  6.1
• 危险品标志：
  T
• 安全说明：
  S28A,S36/37/39,S38,S45
• 危险类别码：
  R23/24/25
• 海关编码：
  2933399090
• 危险品运输编号：
  2811
• RTECS号：
  OJ8490170
• 包装等级：
  III
• 危险类别：
  6.1
• WGK Germany：
  3

SDS

Name:	Lobeline sulfate 99% Material Safety Data Sheet
Synonym:
CAS:	134-64-5

Section 1 - Chemical Product MSDS Name:Lobeline sulfate 99% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
134-64-5	Lobeline sulfate	99%	205-151-8

Hazard Symbols: T
Risk Phrases: 23/24/25

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Toxic in contact with skin.
Ingestion:
May cause irritation of the digestive tract. Poison by ingestion.
Inhalation:
May cause respiratory tract irritation. Toxic if inhaled.
Chronic:
Repeated exposure may cause central nervous system damage.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid immediately. Wash mouth out with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use carbon dioxide or dry chemical.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 134-64-5: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 152-154 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: In about 30 parts H2O
Specific Gravity/Density:
Molecular Formula: C44H56N2O8S
Molecular Weight: 773.01

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, acid chlorides, acid anhydrides.
Hazardous Decomposition Products:
Hydrogen cyanide, sulfur dioxide, carbon monoxide, oxides of nitrogen, carbon dioxide, sulfuric acid, nitric acid.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 134-64-5: OJ8490170 LD50/LC50:
Not available.
Carcinogenicity:
Lobeline sulfate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION
Other No information available.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Alkaloid solid, N.O.S.*
Hazard Class: 6.1
UN Number: 1544
Packing Group: III
IMO
Shipping Name: Alkaloid solid, N.O.S.
Hazard Class: 6.1
UN Number: 1544
Packing Group: III
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 38 In case of insufficient ventilation, wear
suitable respiratory equipment.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 134-64-5: No information available.
Canada
CAS# 134-64-5 is listed on Canada's DSL List.
CAS# 134-64-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 134-64-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生物活性

Lobelin sulphate（洛贝林硫酸盐，Bantron）对烟碱性胆碱能受体具有与尼古丁类似的作用。它被应用于多种疾病的治疗，包括呼吸道疾病、周围性血管疾病、失眠症以及戒烟过程。

靶点

IC50：内源性代谢物

文献信息

• HERBAL PREPARATION FOR SLEEP APNEA RELIEF
  申请人：Frank Steven R.

  公开号：US20100015261A1

  公开（公告）日：2010-01-21

  An herbal preparation for relief of sleep apnea contains lobelia and/or lobelia extract material acting as a respiratory stimulant in combination with meadowsweet to reduce nausea. Optional but preferred materials also include thyme to increase pleural activity, together with chamomile and cramp bark to facilitate relaxation.
• US9226944B2
  申请人：——

  公开号：US9226944B2

  公开（公告）日：2016-01-05