Sinigrin monohydrate [MI] | 64550-88-5

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Sinigrin monohydrate [MI]
• 英文别名: potassium;[(Z)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylbut-3-enylideneamino] sulfate;hydrate
• CAS: 64550-88-5
• 化学式: C10H18KNO10S2
• 分子量: 415.5
• InChiKey: IUBVMJHASFBYGW-YEIBXKIESA-M

物化性质

• 熔点：
  128 (dec.)(lit.)
• 溶解度：
  DMSO（少许）、甲醇（少许）、水（少许）
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  -5.93
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  204
• 氢给体数：
  5
• 氢受体数：
  12

安全信息

• 安全说明：
  S24/25

制备方法与用途

化学性质
白色结晶粉末，可溶于甲醇、乙醇和DMSO等有机溶剂，来源于十字花科植物白芥（Sinapis alba L.）的种子。

用途
黑芥子硫苷酸钾一水具有抗炎和抗癌的作用。

文献信息

• COMPOSITIONS AND METHODS FOR TREATING CANCER
  申请人：Ho John Wing Shing

  公开号：US20100120703A1

  公开（公告）日：2010-05-13

  Pharmaceutical compositions comprising sinigrin and a pharmaceutically acceptable carrier and use thereof for treating liver cancer. A method for treatment of liver cancer in a subject comprising administering to the subject in need thereof and suffering from cancer, a pharmaceutically effective amount of sinigrin, is also provided.

  药物组合物包括芥子甙和药用可接受载体，用于治疗肝癌。还提供了一种治疗肝癌的方法，包括向需要治疗的患有癌症的受试者施用药学有效量的芥子甙。
• Electrostatic protein/glucosinolate complexes
  申请人：Nestec S.A.

  公开号：EP2229823A1

  公开（公告）日：2010-09-22

  The present invention relates to the field of electrostatic complexes. Embodiments of the present invention relate to food-grade electrostatic complexes containing at least one milk protein and at least one glucosinolate and to the uses of such complexes, e.g., to reduce the perceived bitterness of glucosinolates and/or to form and stabilize emulsions and/or foams.

  本发明涉及静电络合物领域。本发明的实施方案涉及含有至少一种牛奶蛋白和至少一种葡萄糖苷酸的食品级静电络合物，以及此类络合物的用途，例如，降低葡萄糖苷酸的苦味和/或形成并稳定乳液和/或泡沫。
• Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
  申请人：Laboratory Skin Care, Inc.

  公开号：US10350168B2

  公开（公告）日：2019-07-16

  Dermal delivery compositions are provided. Aspects of the dermal delivery compositions include the presence of active agent-calcium phosphate particle complexes, where these complexes include uniform, rigid, spherical nanoporous calcium phosphate particles associated with one or more active agents. Also provided are methods of using the compositions in active agent delivery applications.

  提供了皮肤给药组合物。皮肤给药组合物的各个方面包括活性剂-磷酸钙颗粒复合物的存在，其中这些复合物包括与一种或多种活性剂相关联的均匀、硬质、球形纳米多孔磷酸钙颗粒。此外，还提供了在活性剂递送应用中使用这些组合物的方法。
• COMPOSITIONS AND METHODS FOR INCREASING PHYTOCHEMICAL BIOAVAILABLITY AND BIOACTIVITY
  申请人：North Carolina State University

  公开号：EP3657956A1

  公开（公告）日：2020-06-03
• FOOD OR DRINK PRODUCTS, SUPPLEMENTS OR ADDITIVES PRODUCED FROM HIGH GLUCORAPHANIN-CONTAINING BROCCOLI VARIETY 'HOPKINS'
  申请人：Caudill Dan

  公开号：US20080131578A1

  公开（公告）日：2008-06-05

  High concentrations of glucoraphanin, and its isothiocyanate derivative, sulforaphane, can be obtained from whole plants, plant parts or extracts obtained from a new and distinct, highly inbred, and highly self-compatible Brassica oleracea L. (Italica group) broccoli variety designated ‘Hopkins’. The new broccoli variety ‘Hopkins’ produces consistent yields of seed with a consistent high glucoraphanin concentration of greater than 60 μmole of glucoraphanin per gram of seed (with an average range of 68-85 μmole of glucoraphanin per gram of seed) when analyzed by Hydrophilic Interaction Liquid Chromatography (HILIC) and greater than 80 μmol of glucoraphanin per gram of seed (with an average range of 85-105 μmole of glucoraphanin per gram of seed) when analyzed by C 18 Reverse-Phase HPLC.