genistein 4'-O-phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: genistein 4'-O-phosphate
• 英文别名: [4-(5,7-Dihydroxy-4-oxochromen-3-yl)phenyl] dihydrogen phosphate；[4-(5,7-dihydroxy-4-oxochromen-3-yl)phenyl] dihydrogen phosphate
• 化学式: C₁₅H₁₁O₈P
• 分子量: 350.221
• InChiKey: RFKQKIATBVYONP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  染料木素 在 benzopyrone phosphate synthetase 作用下， 反应 1.0h， 生成 genistein 4'-O-phosphate 、 [5-hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-7-yl]dihydrogen phosphate
  参考文献：
  名称：

  METHOD OF BIOTRANSFORMATION OF BENZOPYRONE COMPOUNDS INTO THE CORRESPONDING PHOSPHATE-CONJUGATED DERIVATIVES

  摘要：

  本发明涉及一种生物转化过程，通过一种具有苯并吡喃磷酸合酶活性的分离多肽实现，并且包括一种编码该多肽的核酸序列的微生物，用于制备苯并吡喃化合物的磷酸共轭衍生物。经本发明的苯并吡喃磷酸合酶催化后，苯并吡喃化合物的亲水性质得到增强。

  公开号：

  US20170305944A1

文献信息

• METHOD OF BIOTRANSFORMATION OF BENZOPYRONE COMPOUNDS INTO THE CORRESPONDING PHOSPHATE-CONJUGATED DERIVATIVES
  申请人：National Taiwan University

  公开号：US20170305944A1

  公开（公告）日：2017-10-26

  The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase activity, and also a microorganism comprising a nucleic acid sequence that encodes the polypeptide, for the preparation of phosphate-conjugated derivatives of benzopyrone compounds. The hydrophilic property of the benzopyrone compounds is enhanced after catalyzed by the benzopyrone phosphate synthetase of the present invention.

  本发明涉及一种生物转化过程，通过一种具有苯并吡喃磷酸合酶活性的分离多肽实现，并且包括一种编码该多肽的核酸序列的微生物，用于制备苯并吡喃化合物的磷酸共轭衍生物。经本发明的苯并吡喃磷酸合酶催化后，苯并吡喃化合物的亲水性质得到增强。
• Method of biotransformation of benzopyrone compounds into the corresponding phosphate-conjugated derivatives
  申请人：National Taiwan University

  公开号：US10421768B2

  公开（公告）日：2019-09-24

  The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase activity, and also a microorganism comprising a nucleic acid sequence that encodes the polypeptide, for the preparation of phosphate-conjugated derivatives of benzopyrone compounds. The hydrophilic property of the benzopyrone compounds is enhanced after catalyzed by the benzopyrone phosphate synthetase of the present invention.

  本发明涉及一种生物转化过程，该过程通过一种具有吡喃苯酮磷酸合成酶活性的分离多肽和一种包含编码该多肽的核酸序列的微生物来实现，用于制备吡喃苯酮化合物的磷酸结合衍生物。经本发明的苯并吡喃酮磷酸合成酶催化后，苯并吡喃酮化合物的亲水性增强。
• Method for treatment or prevention of a disease associated with a decrease in bone mass and method of improving bone architecture and bio mechanical strength of bone
  申请人：HUGHES BIOTECHNOLOGY CO., LTD

  公开号：US10881634B2

  公开（公告）日：2021-01-05

  The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.

  本发明提供了一种治疗或预防与骨量下降有关的疾病的方法，包括向需要这种治疗的受试者施用一种包含有效量的基因素磷酸酯共轭物的组合物。本发明还提供了一种改善骨结构和骨的生物机械强度的方法，包括向需要这种治疗的受试者施用一种包含有效量的基因素磷酸轭合物的组合物。本发明向需要此类治疗的受试者施用包含有效量的染料木素磷酸酯共轭物的组合物，可有效提高口服生物利用度，从而减轻更年期妇女的症状和并发症风险，增加骨矿物质含量、骨密度和骨的生物力学强度，减缓骨质疏松症。
• COMPOSITIONS COMPRISING 7-O-GENISTEIN PHOSPHATE FOR USE IN THE TREATMENT OF PRIMARY OSTEOPOROSIS
  申请人：Hughes Biotechnology Co., Ltd.

  公开号：EP3494973B1

  公开（公告）日：2021-07-28
• METHOD FOR TREATMENT OR PREVENTION OF A DISEASE ASSOCIATED WITH A DECREASE IN BONE MASS AND METHOD OF IMPROVING BONE ARCHITECTURE AND BIO-MECHANICAL STRENGTH OF BONE
  申请人：HUGHES BIOTECHNOLOGY CO., LTD

  公开号：US20190175545A1

  公开（公告）日：2019-06-13

  The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.