Rubrenolide, total synthesis and revision of its reported stereochemical structure
作者:L Thijs、B Zwanenburg
DOI:10.1016/j.tet.2004.04.037
日期:2004.6
In this paper the synthesis of the natural product rubrenolide is presented. Due to an error in the original proposed stereochemical structure of rubrenolide, the synthesis was not straightforward. Application of the photo-induced rearrangement of an appropriate epoxy diazomethyl ketone gave access to the precursor lactone with an ee of 91%. Coupling of this lactone with (4S)-2,2-dimethyl-[1,3]-di