邻苯基苯酚缩水甘油醚 | 7144-65-2

• 物质功能分类: 有机原料 - 醚类化合物及其衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 邻苯基苯酚缩水甘油醚
• 中文别名: 2-苯基苯酚缩水甘油醚；2-联苯缩水甘油醚；3-(2-联苯)-1,2-环氧丙烷
• 英文名称: 2-(([1,1'-biphenyl]-2-yloxy)methyl)oxirane
• 英文别名: 2-((biphenyl-2-yloxy)methyl)oxirane；2-(([1,1′-biphenyl]-2-yloxy)methyl)oxirane；2-Biphenylyl glycidyl ether；2-[(2-phenylphenoxy)methyl]oxirane
• CAS: 7144-65-2
• 化学式: C₁₅H₁₄O₂
• mdl: MFCD00046989
• 分子量: 226.275
• InChiKey: DNVXWIINBUTFEP-UHFFFAOYSA-N

物化性质

• 熔点：
  31°C
• 沸点：
  200°C/13mmHg(lit.)
• 密度：
  1.0891 (rough estimate)
• 稳定性/保质期：
  遵照规格使用和储存则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• RTECS号：
  SL7800000
• 海关编码：
  2910900090
• 储存条件：
  请将密封于阴凉干燥处。

SDS

Name:	2-Biphenylyl Glycidyl Ether 95% Material Safety Data Sheet
Synonym:	3-(2-Biphenylyloxy)-1,2-Epoxypropane; Ether, 2-Biphenyl 2,3-epoxypropyl
CAS:	7144-65-2

Section 1 - Chemical Product MSDS Name:2-Biphenylyl Glycidyl Ether 95% Material Safety Data Sheet
Synonym:3-(2-Biphenylyloxy)-1,2-Epoxypropane; Ether, 2-Biphenyl 2,3-epoxypropyl

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7144-65-2	2-Biphenylyl Glycidyl Ether	95%	230-451-0

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 7144-65-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 120 deg C @ .10mmHg
Freezing/Melting Point: 30.00 - 32.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C15H14O2
Molecular Weight: 226.27

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7144-65-2: RR0356000 LD50/LC50:
Not available.
Carcinogenicity:
2-Biphenylyl Glycidyl Ether - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 7144-65-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 7144-65-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7144-65-2 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  邻苯基苯酚缩水甘油醚 在 diisobutylaluminum borohydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以90%的产率得到1-([1,1'-biphenyl]-2-yloxy)propan-2-ol
  参考文献：
  名称：

  二氢化硼二异丁基铝氢化物与含有代表性官能团的某些有机化合物的反应

  摘要：

  由氢化二异丁基铝（DIBAL）和硼烷二甲基硫醚（BMS）合成的二元氢化物二异丁基硼氢化铝[（i Bu）2 AlBH 4 ]在还原各种有机官能团方面显示出巨大潜力。这种独特的二元氢化物（i Bu）2 AlBH 4易于合成，通用且易于使用。醛，酮，酯和环氧化物以基本定量的收率非常快地还原为相应的醇。该二元氢化物可以在25°C下以有效方式将叔酰胺迅速还原为相应的胺。此外，腈以基本上定量的产率转化为相应的胺。这些反应在环境条件下发生，并在一个小时或更短的时间内完成。还原产物可通过简单的酸碱萃取而分离，无需使用柱色谱法。进一步的研究表明（i Bu）2 AlBH 4如一系列竞争反应所示，它具有成为选择性氢化物供体的潜力。讨论了（i Bu）2 AlBH 4，DIBAL和BMS之间的异同。

  DOI：

  10.1021/acs.joc.0c03062
• 作为产物：
  描述：

  邻苯基苯酚 在 sodium hydroxide 作用下， 以 水 、 环氧氯丙烷 为溶剂， 生成 邻苯基苯酚缩水甘油醚
  参考文献：
  名称：

  1-(Trialkylamino)-3-(phenylphenoxy)-2-propanol quarternary salts

  摘要：

  上述标题化合物表现出强大且长效的抗心律失常活性，同时缺乏相关先前技术化合物特征的不良副作用，例如β-肾上腺能受体阻滞活性和局部麻醉活性。

  公开号：

  US04241088A1

文献信息

• Ruthenium-Catalyzed Selective Hydrogenation of Epoxides to Secondary Alcohols
  作者：Subramanian Thiyagarajan、Chidambaram Gunanathan

  DOI：10.1021/acs.orglett.9b03995

  日期：2019.12.6

  A ruthenium(II)-catalyzed highly selective Markovnikov hydrogenation of terminal epoxides to secondary alcohols is reported. Diverse substitutions on the aryl ring of styrene oxides are tolerated. Benzylic, glycidyl, and aliphatic epoxides as well as diepoxides also underwent facile hydrogenation to provide secondary alcohols with exclusive selectivity. Metal-ligand cooperation-mediated ruthenium trans-dihydride

  据报道，钌（II）催化末端环氧化物向仲醇的高选择性马尔科夫尼科夫加氢反应。容许在苯乙烯氧化物的芳基环上的多个取代。苯甲酸，缩水甘油基和脂肪族的环氧化物以及二环氧化物也容易进行氢化，以提供具有独特选择性的仲醇。对于观察到的选择性的起源，设想了金属-配体配合介导的钌-二氢化钌的形成及其反应，该反应涉及氧和环氧化物的较少取代的末端碳。
• AROMATIC GLYCOL ETHERS AS WRITING MONOMERS IN HOLOGRAPHIC PHOTOPOLYMER FORMULATIONS
  申请人：COVESTRO DEUTSCHLAND AG

  公开号：US20170045816A1

  公开（公告）日：2017-02-16

  The invention relates to a photopolymer formulation comprising specific aromatic glycol ethers as writing monomers, matrix polymers and a photoinitiator. The invention further provides an unexposed holographic medium obtainable using an inventive photopolymer formulation, and an exposed holographic medium obtainable by exposing a hologram into an inventive unexposed holographic medium. The invention likewise provides a visual display comprising an inventive exposed holographic medium, for the use of an inventive exposed holographic medium for production of chip cards, identification documents, 3D images, product protection labels, labels, banknotes or holographic optical elements, and specific aromatic glycol ethers.

  本发明涉及一种光聚合配方，包含特定的芳香族乙二醇醚作为写入单体、基质聚合物和光引发剂。本发明还提供了一种使用创新光聚合配方可获得的未曝光全息介质，以及通过将全息图曝光到创新的未曝光全息介质中获得的曝光全息介质。本发明同样提供了一种包含创新曝光全息介质的视觉显示，用于创新曝光全息介质在生产芯片卡、身份证件、三维图像、产品保护标签、标签、钞票或全息光学元件中的应用，以及特定的芳香族乙二醇醚。
• High yield room temperature conversion of carbon dioxide into cyclic carbonates catalyzed by mixed metal oxide (CuO‐ZnO) nano‐flakes/micro‐flakes (Cozi‐nmf)
  作者：Venkateswara Rao Velpuri、Krishnamurthi Muralidharan

  DOI：10.1002/aoc.6224

  日期：2021.6

  Capturing and converting carbon dioxide (CO2) into useful organic molecules and polymers is the best way of alleviating excessive release of it from industrial sources to the environment. Cyclic carbonate synthesis by cycloaddition from CO2 and epoxides through a catalytic process is a 100% atom economic reaction established five decades ago. Despite the availability of many efficient catalytic systems

  捕获并将二氧化碳（CO 2）转化为有用的有机分子和聚合物是减轻二氧化碳从工业来源向环境中过度释放的最佳方法。通过催化过程由CO 2和环氧化物进行环加成合成环碳酸酯是五十年前建立的100％原子经济反应。尽管有许多有效的催化系统可用，但是在乏味的催化剂制备过程中，与均相催化有关的分离问题或需要纯CO 2方面存在缺陷。在这项工作中，我们报告了基于铜和锌混合金属氧化物（CuO-ZnO）纳米片/微片（Cozi-nmf）的催化体系，用于CO的环加成2在室温下于无溶剂条件下使用各种环氧化物。通过简单的方法，在室温下通过研磨工艺成功地制备了新型可循环利用的非均相催化剂。本文所述的催化剂和环状碳酸酯的合成更绿色，并且使用廉价的原料生产它们。除了许多反应之外，合成的环状碳酸酯的产率超过95％。Cozi-nmf作为催化剂的高效率是基于裸露的催化剂表面的可用性来解释的，该表面有效地促进了电子的无障碍自由移动和底物的吸附。
• Copper-catalyzed/mediated borylation reactions of epoxides with diboron reagents: access to β-hydroxyl boronic esters
  作者：Ebrahim-Alkhalil M. A. Ahmed、Xi Lu、Tian-Jun Gong、Zhen-Qi Zhang、Bin Xiao、Yao Fu

  DOI：10.1039/c6cc07924e

  日期：——

  We report the first copper-catalyzed/mediated borylative ring opening reaction of epoxides.

  我们报道了环氧的第一个铜催化/介导的硼化开环反应。
• Copper-catalyzed cross-coupling reactions of epoxides with gem-diborylmethane: access to γ-hydroxyl boronic esters
  作者：Ahmed Ebrahim-Alkhalil、Zhen-Qi Zhang、Tian-Jun Gong、Wei Su、Xiao-Yu Lu、Bin Xiao、Yao Fu

  DOI：10.1039/c5cc09817c

  日期：——

  Herein, we describe a novel copper-catalyzed epoxide opening reaction with gem-diborylmethane.

  在本文中，我们描述了与宝石-二硼烷基甲烷的新型铜催化的环氧化物开环反应。

表征谱图