噻吩-3-硫醇 | 7518-22-1

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 噻吩-3-硫醇
• 中文别名: 楤木皂苷A；木皂苷A；楤木皂甙A；楤木皂苷A,木皂苷A
• 英文名称: Araloside A
• 英文别名: (2S,3S,4R,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid
• CAS: 7518-22-1
• 化学式: C₄₇H₇₄O₁₈
• 分子量: 927.1
• InChiKey: KQSFNXMDCOFFGW-GNDIVNLPSA-N

物化性质

• 熔点：
  196-200℃ (decomposition)
• 沸点：
  999.1±65.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)
• 溶解度：
  溶于乙腈和甲醇；

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  65
• 可旋转键数：
  10
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  292
• 氢给体数：
  10
• 氢受体数：
  18

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

Araloside A（竹节参皂苷IV）是竹节参中的一种成分，对肾素具有低抑制活性，其IC50值为77.4 μM。

靶点

• IC50: 77.4 μM (Renin)

化学性质

Araloside A是一种白色结晶粉末，可溶于甲醇、乙醇和DMSO等有机溶剂。它来源于楤木。

用途

适用于含量测定、鉴定以及药理实验等。

文献信息

• SKIN TISSUE REGENERATION PROMOTERS COMPRISING GINSENOSIDE Rb1
  申请人：JAPAN SCIENCE AND TECHNOLOGY CORPORATION

  公开号：EP1295893A1

  公开（公告）日：2003-03-26

  Efficacious intravenous preparations, skin preparations for external use, mucosal preparations for external use or cosmetics comprising ginsenosides, in particular, ginsenoside Rb or its derivative which are useful as skin tissue regeneration/reconstruction promoters or wound healing promoters; and fertilizer additives comprising ginsenosides, in particular, ginsenoside Rb or its derivative which are useful as plant tissue regeneration/reconstruction promoters. These intravenous preparations, skin preparations for external use, mucosal preparations for external use or cosmetics are useful particularly in promoting the tissue regeneration/reconstruction in incised wounds, open wounds, bite wounds and missing of skin or mucosa or in promoting would healing. The above fertilizer additives are useful particularly in water culturing and raising crops.

  有效的静脉注射制剂、外用皮肤制剂、外用粘膜制剂或化妆品，其中包含可用作皮肤组织再生/重建促进剂或伤口愈合促进剂的人参皂甙，特别是人参皂甙 Rb 或其衍生物；以及包含可用作植物组织再生/重建促进剂的人参皂甙，特别是人参皂甙 Rb 或其衍生物的肥料添加剂。这些静脉注射制剂、外用皮肤制剂、外用粘膜制剂或化妆品特别适用于促进切口、开放性伤口、咬伤、皮肤或粘膜缺损的组织再生/重建，或促进伤口愈合。上述肥料添加剂尤其适用于水培养和作物栽培。
• Skin tissue regeneration promoters comprising ginsenoside Rb1
  申请人：Japan Science and Technology Corporation, Japan

  公开号：US20030104079A1

  公开（公告）日：2003-06-05

  The present invention provides efficacious preparations for intravenous administration, preparations for external or topical application to skin, preparations for external or topical application to mucosa or cosmetics comprising ginsenosides, in particular, ginsenoside Rb 1 or its derivatives which are useful as skin tissue regeneration/reconstruction promoters or wound healing promoters; and it provides fertilizer additives comprising ginsenosides, in particular, ginsenoside Rb 1 or its derivatives which are useful as plant tissue regeneration/reconstruction promoters. These preparations for intravenous administration, preparations for external or topical application to skin, preparations for external or topical application to mucosa or cosmetics are useful particularly for promoting the tissue regeneration/reconstruction in cases of incised wounds, morsus, bite wounds and/or defect of skin or mucosa or for promoting would healing. The above fertilizer additives are useful particularly for hydroponics and raising of farm products.

  本发明提供了有效的静脉注射制剂、皮肤外用或局部外用制剂、粘膜外用或局部外用制剂或化妆品，其中包含人参皂甙，特别是人参皂甙 Rb 1 或其衍生物，可用作皮肤组织再生/重建促进剂或伤口愈合促进剂；还提供了含有人参皂甙，特别是人参皂甙 Rb 1 或其衍生物组成的肥料添加剂，可用作植物组织再生/重建促进剂。这些用于静脉注射的制剂、用于皮肤外用或局部涂抹的制剂、用于粘膜外用或局部涂抹的制剂或化妆品特别适用于促进皮肤或粘膜的切口、伤口、咬伤和/或缺损的组织再生/重建，或促进伤口愈合。上述肥料添加剂尤其适用于水栽法和农产品养殖。