大豆皂苷II | 55319-36-3

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 大豆皂苷II
• 英文名称: soyasaponin II
• 英文别名: (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid
• CAS: 55319-36-3
• 化学式: C₄₇H₇₆O₁₇
• 分子量: 913.11
• InChiKey: IBZLICPLPYSFNZ-IVWMTKFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  64
• 可旋转键数：
  8
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  275
• 氢给体数：
  10
• 氢受体数：
  17

制备方法与用途

生物活性

Soyasaponin II 是一种具有抗病毒活性的皂苷，能够抑制 HSV-1、HCMV、流感病毒和 HIV-1 的复制。其中，它对 HSV-1 复制显示出有效的抑制作用，并且能作为 YB-1 磷酸化和 NLRP3 炎性小体引发的抑制剂，保护小鼠免受 LPS/GalN 诱导的急性肝衰竭。

目标

HSV-1 54 μM (IC50)

HIV-1 112 μM (IC50)

流感病毒 88 μM (IC50)

HCMV 104 μM (IC50)

NLRP3 炎性小体

体外研究

Soyasaponin II 抑制 HSV-1（IC₅₀=54 μM）、HCMV（104 μM）、流感病毒（88 μM）和 HIV-1（112 μM）的复制。

体内研究

给予小鼠 Soyasaponin II（5 mg/kg，每天一次连续三天口服），可以改善经典 NLRP3 炎性小体相关固有免疫反应。

文献信息

• Oleanene-type triterpene glycosides as masking agents
  申请人：Symrise AG

  公开号：EP2559346A1

  公开（公告）日：2013-02-20

  The present invention relates to the use of certain oleanene-type triterpene glycosides of formula (I) and/or physiologically acceptable salts thereof wherein M is hydrogen or hydroxyl, preferably hydroxyl, and A is a carbohydrate moiety, preferably an oligosaccharide moiety, for modifying (i.e. modulating) or masking (i.e. reducing or suppressing) unpleasant taste impressions, in particular bitter and/or astringent taste impressions and to a corresponding method for modulating or masking an unpleasant taste of a substance or substance mixture. The present invention also relates to compositions, in particular orally consumable compositions, comprising (a) one or more compounds of formula (I) or a physiologically acceptable salt thereof, and (b) one or more substances with unpleasant taste, in particular bitter and/or astringent taste.

  本发明涉及式 (I) 的某些齐墩果烯型三萜苷和/或其生理上可接受的盐的用途 其中 M 是氢或羟基，最好是羟基，以及 A 是碳水化合物分子，最好是寡糖分子、 用于改变（即调节）或掩盖（即减少或抑制）不愉快的味道印象，特别是苦味和/或涩味印象，以及用于调节或掩盖物质或物质混合物的不愉快味道的相应方法。 本发明还涉及组合物，特别是口服组合物，包括(a)一种或多种式(I)化合物或其生理上可接受的盐，和(b)一种或多种具有令人不快的味道，特别是苦味和/或涩味的物质。
• PROMOTER FOR LEGUMINOUS PLANT GROWTH
  申请人：KAO CORPORATION

  公开号：US20200045983A1

  公开（公告）日：2020-02-13

  It is intended to provide a component promoting the growth of leguminous plants. The present invention provides a promoter for leguminous plant growth comprising a glycoside of soyasapogenol B as an active ingredient, and a method for promoting the growth of a leguminous plant using a glycoside of soyasapogenol B as an active ingredient. The glycoside of soyasapogenol B is a glycoside having a hydroxy group at position C-22 of the soyasapogenol B and having a saccharide bonded to a hydroxy group at position C-3 of the soyasapogenol B.
• [EN] OLEANENE-TYPE TRITERPENE GLYCOSIDES AS MASKING AGENTS<br/>[FR] GLYCOSIDES TRITERPÉNIQUES DE TYPE OLÉANÈNE EN TANT QU'AGENTS DE MASQUAGE
  申请人：SYMRISE AG

  公开号：WO2013023891A1

  公开（公告）日：2013-02-21

  The present invention relates to the use of certain oleanene-type triterpene glycosides of formula (I) and/or physiologically acceptable salts thereof formula (I) wherein M is hydrogen or hydroxyl, preferably hydroxyl, and A is a carbohydrate moiety, preferably an oligosaccharide moiety, for modifying (i.e. modulating) or masking (i.e. reducing or suppressing) unpleasant taste impressions, in particular bitter and/or astringent taste impressions and to a corresponding method for modulating or masking an unpleasant taste of a substance or substance mixture. The present invention also relates to compositions, in particular orally consumable compositions, comprising (a) one or more compounds of formula (I) or a physiologically acceptable salt thereof, and (b) one or more substances with unpleasant taste, in particular bitter and/or astringent taste.
• [EN] FOOD COMPOSITIONS COMPRISING FLAVAN-3-OLS<br/>[FR] COMPOSITIONS ALIMENTAIRES COMPRENANT DES FLAVAN-3-OLS
  申请人：UNILEVER PLC

  公开号：WO2013023942A1

  公开（公告）日：2013-02-21

  Disclosed are food compositions comprising certain compounds and flavan-3-ols such as catechins and other tea-derived flavan-3-ols. Also disclosed are methods for manufacturing the compositions and use of the compounds for reducing or eliminating an unpleasant taste caused by the flavan-3-ols in food compositions. The compounds are those of formula (I) or a physiologically acceptable salt thereof, wherein M is hydrogen or hydroxyl, preferably hydroxyl, and A is a carbohydrate moiety, preferably an oligosaccharide moiety.